Skip to main content

Chronic Wounds

  • Chapter
  • First Online:
Autologous fat tissue transfer
  • 570 Accesses

Abstract

Chronic wounds of the lower extremities generally pose a huge challenge not only in plastic surgery but also in gen But also in general surgical practice. Existing ailments like diabetes mellitus or peripheral vascular disease after delay adequate wound healing using conservative or conventional therapy. A new study now shows that using a simple technique of autologous lipotransfer, wounds, which were therapy-resistant on earlier occasions, completely healed within a period of a few weeks. Chronic wounds on the feet of diabetic patients or in case of vascular diseases were debrided and filled up with autologous fat tissue recovered from the lower abdomen or the upper thigh (lipofilling or lipotransfer). This method, which can be used even in case of chronic burn scars or fibrous tissue, is highly successful. This is because stem cells contained in the fat tissue (ADSC) and growth factors convert the chronic wound condition into an acute wound environment, which accelerates the wound healing.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 99.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Mojallal A, Lequeux C, Shipkov C, et al. Improvement of skin quality after fat grafting: clinical observation and an animal study. Plast Reconstr Surg. 2009;124(3):765–74.

    Article  CAS  Google Scholar 

  2. Rigotti G, Marchi A, Galie M, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg. 2007;119(5):1409–22; discussion 1423–1404.

    Article  CAS  Google Scholar 

  3. Klinger M, Caviggioli F, Forcellini D, Villani F. Scars: a review of emerging and currently available therapies. Plast Reconstr Surg. 2009;124(1):330.

    Article  CAS  Google Scholar 

  4. Caviggioli F, Klinger FM, Vinci V, et al. Treatment of chronic posttraumatic leg injury using autologous fat graft. Case Rep Med. 2012;2012:648683.

    Article  Google Scholar 

  5. Klinger M, Caviggioli F, Vinci V, et al. Treatment of chronic posttraumatic ulcers using autologous fat graft. Plast Reconstr Surg. 2010;126(3):154e–5e.

    Article  Google Scholar 

  6. Marangi GF, Pallara T, Cagli B, et al. Treatment of early-stage pressure ulcers by using autologous adipose tissue grafts. Plast Surg Int. 2014;2014:817283.

    PubMed  PubMed Central  Google Scholar 

  7. Stasch T, Hoehne J, Huynh T, et al. Débridement and autologous lipotransfer for chronic ulceration of the diabetic foot and lower limb improves wound healing. Plast Reconstr Surg. 2015;136(6):1357–66.

    Article  CAS  Google Scholar 

  8. Reverdin JL. Greffeépidermique. Expérience fait dans le service de M. le docteurGuyon, à l´hôpital Necker. Bull Imp Soc Chir. 1869;10:511–5.

    Google Scholar 

  9. Marino G, Moraci M, Armenia E, et al. Therapy with autologous adipose-derived regenerative cells for the care of chronic ulcer of lower limbs in patients with peripheral arterial disease. J Surg Res. 2013;185(1):36–44.

    Article  Google Scholar 

  10. Shibata S, Tada Y, Asano Y, et al. Adiponectin regulates cutaneous wound healing by promoting keratinocyte proliferation and migration via the ERK signaling pathway. J Immunol. 2012;189(6):3231–41.

    Article  CAS  Google Scholar 

  11. Li PB, Jin H, Liu DX, et al. [Study on leptin enhancing collagen synthesis in wounded rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011;27(1):72–4.

    Google Scholar 

  12. Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995;269(5223):543–6.

    Article  CAS  Google Scholar 

  13. Eppley BL, Sidner RA, Platis JM, Sadove AM. Bioactivation of free-fat transfers: a potential new approach to improving graft survival. Plast Reconstr Surg. 1992;90(6):1022–30.

    Article  CAS  Google Scholar 

  14. Frank S, Stallmeyer B, Kampfer H, et al. Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair. J Clin Invest. 2000;106(4):501–9.

    Article  CAS  Google Scholar 

  15. Pallua N, Pulsfort AK, Suschek C, Wolter TP. Content of the growth factors bFGF, IGF-1, VEGF, and PDGF-BB in freshly harvested lipoaspirate after centrifugation and incubation. Plast Reconstr Surg. 2009;123(3):826–33.

    Article  CAS  Google Scholar 

  16. Cervelli V, Gentile P, Scioli MG, et al. Application of platelet-rich plasma in plastic surgery: clinical and in vitro evaluation. Tissue Eng Part C Methods. 2009;15(4):625–34.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Stasch, T. (2019). Chronic Wounds. In: Ueberreiter, K. (eds) Autologous fat tissue transfer. Springer, Cham. https://doi.org/10.1007/978-3-030-05402-1_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-05402-1_14

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-05401-4

  • Online ISBN: 978-3-030-05402-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics