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Wrinkled Polymer Surfaces pp 109–141Cite as

Wrinkled Hydrogel Formation by Interfacial Swelling on Thermoplastic Surfaces

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Abstract

The development of simple strategies capable of simultaneously producing hydrophilic surfaces and controlled surface topography is rare in spite of their huge potential for a wide myriad of applications. Herein, we first summarize the different strategies to fabricate microstructured hydrogel surfaces and the different biological applications described in the literature. Then, we describe a procedure used to fabricate wrinkled structures in thermoplastics. We present a straightforward approach to form microwrinkled surfaces on polycarbonate (PC) film after a process that involves three different steps: first, the contact between a photosensitive monomer mixture based on vinylpyrrolidone (VP) and the PC substrate; second, a UV-curing step of this solution; and third, the hydrogel detachment as a result of the swelling in ethanol. Several parameters allow us to vary the wrinkle characteristics including the contact time between the PC surface and the photopolymerizable solution prior to the UV-vis irradiation, the type of solvent, as well as the cross-linking degree. By contact angle measurements and by confocal Raman microscopy, we were able to demonstrate that the PC wrinkled surface produced after hydrogel detachment has a thin hydrogel layer. Thus the hydrogel presented an internal rupture close to the PC substrate. Finally, we evaluated biocompatibility analyzing cell proliferation, cell morphology, and cell detachment on the substrates with both variable chemical composition and wrinkle size and period.

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Acknowledgments

The authors gratefully acknowledge support from the Consejo Superior de Investigaciones Científicas (CSIC). Equally, this work was financially supported by the Ministerio de Economía y Competitividad (MINECO) through MAT2013-47902-C2-1-R, MAT2013-42957-R, and MAT2016-78437-R, FEDER-EU.

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Authors and Affiliations

  1. Instituto de Ciencia y Tecnología de Polímeros (ICTP), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain

    Enrique Martinez, Alberto Gallardo, Noelia Lujan, Helmut Reinecke & Juan Rodríguez-Hernandez

  2. Tissue Engineering Group; Instituto de Estudios Biofuncionales, Associated Unit to the ICTP-CSIC Polymer Functionalization Group, Universidad Complutense de Madrid, Madrid, Spain

    Enrique Martinez & Ana Santos-Coquillat

  3. Instituto de Cerámica y Vidrio (ICV-CSIC), Madrid, Spain

    Adolfo del Campo

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  1. Enrique Martinez
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  2. Alberto Gallardo
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  3. Ana Santos-Coquillat
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  4. Noelia Lujan
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Correspondence to Alberto Gallardo or Juan Rodríguez-Hernandez .

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Editors and Affiliations

  1. Department of Chemistry, Universidad Tecnológica Metropolitana (UTEM), Santiago, RM - Santiago, Chile

    C. M. González-Henríquez

  2. Institute of Polymer Science and Technology (ICTP-CSIC), Madrid, Spain

    Juan Rodríguez-Hernández

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Martinez, E. et al. (2019). Wrinkled Hydrogel Formation by Interfacial Swelling on Thermoplastic Surfaces. In: González-Henríquez, C., Rodríguez-Hernández, J. (eds) Wrinkled Polymer Surfaces. Springer, Cham. https://doi.org/10.1007/978-3-030-05123-5_5

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