Abstract
The big data analytics open a promising path to personalized psychiatry. Along with the opportunities are some unprecedented challenges. In this chapter, we will discuss some of these challenges that we are facing in the field of big data analytics in psychiatry. For example, we are still lacking data standardization in diagnoses, variables and protocols, and we also have limitations in applications of machine learning techniques. However, the field of big data analytics in psychiatry is rapid developing, and we expect to overcome these challenges with the joint force of researchers in related fields in the near future.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Absinta M, Ha SK, Nair G et al (2017) Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI. Elife. 6:e29738. https://doi.org/10.7554/eLife.29738.001
American Psychiatric Association (2013a) Diagnostic and statistical manual of mental disorders, 5th Edition (DSM-5). Diagnostic Stat Manual of Mental Disorder 4th Ed TR. 280. https://doi.org/10.1176/appi.books.9780890425596.744053
American Psychiatric Association (2013b) Highlights of changes from DSM-IV to DSM-5. Focus (Madison) 11(4):525–527. https://doi.org/10.1176/appi.focus.11.4.525
Andreasen NC, Nopoulos P, Magnotta V, Pierson R, Ziebell S, Ho B-C (2011) Progressive brain change in schizophrenia: a prospective longitudinal study of first-episode schizophrenia. Biol Psychiatry 70(7):672–679. https://doi.org/10.1016/j.biopsych.2011.05.017
Armanfard N, Reilly JP, Komeili M (2016a) Local feature selection for data classification. IEEE Trans Pattern Anal Mach Intell 38(6):1217–1227. https://doi.org/10.1109/TPAMI.2015.2478471
Armanfard N, Komeili M, Reilly JP, Mah R, Connolly JF (2016b) Automatic and continuous assessment of ERPs for mismatch negativity detection. In: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol 2016. IEEE, Piscataway, pp 969–972. https://doi.org/10.1109/EMBC.2016.7590863
Armanfard N, Reilly JP, Komeili M (2017) Logistic localized modeling of the sample space for feature selection and classification. IEEE Trans Neural Networks Learn Syst 29(5):1396–1413. https://doi.org/10.1109/TNNLS.2017.2676101
Bellman RE, Dreyfus SE (1962) Applied dynamic programming. Ann Math Stat 33(2):719–726. https://doi.org/10.1289/ehp.1002206
Berk M, Conus P, Lucas N et al (2007) Setting the stage: from prodrome to treatment resistance in bipolar disorder. Bipolar Disord 9(7):671–678. https://doi.org/10.1111/j.1399-5618.2007.00484.x
Bishop CM (2006) Pattern recognition and machine learning. Springer, Berlin. https://doi.org/10.1117/1.2819119
Breiman L, Spector P (1992) Submodel selection and evaluation in regression. The X-random case. Int Stat Rev 60(3):291–319. https://doi.org/10.2307/1403680
Cao B, Passos IC, Mwangi B et al (2016) Hippocampal volume and verbal memory performance in late-stage bipolar disorder. J Psychiatr Res 73:102–107. https://doi.org/10.1016/j.jpsychires.2015.12.012
Cao B, Stanley JA, Passos IC et al (2017a) Elevated choline-containing compound levels in rapid cycling bipolar disorder. Neuropsychopharmacology 42(11):2252–2258. https://doi.org/10.1038/npp.2017.39
Cao B, Mwangi B, Passos IC et al (2017b) Lifespan gyrification trajectories of human brain in healthy individuals and patients with major psychiatric disorders. Sci Rep 7(1):511. https://doi.org/10.1038/s41598-017-00582-1
Cao B, Passos IC, Mwangi B et al (2017c) Hippocampal subfield volumes in mood disorders. Mol Psychiatry 22(9):1–7. https://doi.org/10.1038/mp.2016.262
Cao B, Luo Q, Fu Y et al (2018) Predicting individual responses to the electroconvulsive therapy with hippocampal subfield volumes in major depression disorder. Sci Rep 8(1):5434. https://doi.org/10.1038/s41598-018-23685-9
Chawla NV, Bowyer KW, Hall LO, Kegelmeyer WP (2002) SMOTE: synthetic minority over-sampling technique. J Artif Intell Res 16:321–357. https://doi.org/10.1613/jair.953
Colic S, Wither RG, Lang M, Zhang L, Eubanks JH, Bardakjian BL (2017) Prediction of antiepileptic drug treatment outcomes using machine learning. J Neural Eng 14(1):016002. https://doi.org/10.1088/1741-2560/14/1/016002
GarcÃa-Laencina PJ, Sancho-Gómez J-L, Figueiras-Vidal AR (2010) Pattern classification with missing data: a review. Neural Comput Appl 19(2):263–282. https://doi.org/10.1007/s00521-009-0295-6
Hastie T, Tibshirani R, Friedman J (2009) The elements of statistical learning. Springer, New York. https://doi.org/10.1007/978-0-387-84858-7
Haukvik UK, Westlye LT, Mørch-Johnsen L et al (2015) In vivo hippocampal subfield volumes in schizophrenia and bipolar disorder. Biol Psychiatry 77(6):581–588. https://doi.org/10.1016/j.biopsych.2014.06.020
Haykin S (2009) Neural networks and learning machines, vol 3. Prentice Hall, Upper Saddle River doi:978-0131471399
He H, Garcia EA (2009) Learning from imbalanced data. IEEE Trans Knowl Data Eng 21(9):1263–1284. https://doi.org/10.1109/TKDE.2008.239
Kapczinski NS, Mwangi B, Cassidy RM et al (2016) Neuroprogression and illness trajectories in bipolar disorder. Expert Rev Neurother 7175:1744–8360 (Electronic):1–9. https://doi.org/10.1080/14737175.2017.1240615
Khodayari-Rostamabad A, Hasey GM, MacCrimmon DJ, Reilly JP, de Bruin H (2010) A pilot study to determine whether machine learning methodologies using pre-treatment electroencephalography can predict the symptomatic response to clozapine therapy. Clin Neurophysiol 121(12):1998–2006. https://doi.org/10.1016/j.clinph.2010.05.009
Khodayari-Rostamabad A, Reilly JP, Hasey GM, de Bruin H, MacCrimmon DJ (2013) A machine learning approach using EEG data to predict response to SSRI treatment for major depressive disorder. Clin Neurophysiol 124(10):1975–1985. https://doi.org/10.1016/j.clinph.2013.04.010
Kohavi R (1995) A study of cross-validation and bootstrap for accuracy estimation and model selection. IJCAI 14(2):1–7. https://doi.org/10.1067/mod.2000.109031
Le QV A tutorial on deep learning part 2: autoencoders, convolutional neural networks and recurrent neural networks. Google Brain. 2015:1–20
Le Roux N, Bengio Y (2008) Representational power of restricted Boltzmann machines and deep belief networks. Neural Comput 20(6):1631–1649. https://doi.org/10.1162/neco.2008.04-07-510
Müller KR, Mika S, Rätsch G, Tsuda K, Schölkopf B (2001) An introduction to kernel-based learning algorithms. IEEE Trans Neural Netw 12(2):181–201. https://doi.org/10.1109/72.914517
Panta SR, Wang R, Fries J et al (2016) A tool for interactive data visualization: application to over 10,000 brain imaging and phantom MRI data sets. Front Neuroinform 10:1–12. https://doi.org/10.3389/fninf.2016.00009
Passos IC, Mwangi B, Vieta E, Berk M, Kapczinski F (2016) Areas of controversy in neuroprogression in bipolar disorder. Acta Psychiatr Scand 134(2):91–103. https://doi.org/10.1111/acps.12581
Peng H, Long F, Ding C (2005) Feature selection based on mutual information: criteria of max-dependency, max-relevance, and min-redundancy. IEEE Trans Pattern Anal Mach Intell 27(8):1226–1238. https://doi.org/10.1109/TPAMI.2005.159
Rajkomar A, Oren E, Chen K et al (2018) Scalable and accurate deep learning for electronic health records. npj Digit Med 1(1):1–15. https://doi.org/10.1038/s41746-018-0029-1
Ravan M, Reilly JP, Trainor LJ, Khodayari-Rostamabad A (2011) A machine learning approach for distinguishing age of infants using auditory evoked potentials. Clin Neurophysiol 122(11):2139–2150. https://doi.org/10.1016/j.clinph.2011.04.002
Ravan M, MacCrimmon D, Hasey G, Reilly JP, Khodayari-Rostamabad A (2012) A machine learning approach using P300 responses to investigate effect of clozapine therapy. In: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. IEEE, Piscataway, pp 5911–5914. https://doi.org/10.1109/EMBC.2012.6347339
Rumelhart DE, Hinton GE, Williams RJ (1986) Learning representations by back-propagating errors. Nature 323(6088):533. https://doi.org/10.1038/323533a0
Schapire RE (2003) The boosting approach to machine learning: an overview. Nonlinear Estim Classif 171:149–171 doi:10.1.1.24.5565
Soutullo C, Chang K (2005) Bipolar disorder in children and adolescents: international perspective on epidemiology and phenomenology. Bipolar Disord 7(6):497–506. http://onlinelibrary.wiley.com/doi/10.1111/j.1399-5618.2005.00262.x/full
Stein JL, Hibar DP, Madsen SK et al (2011) Discovery and replication of dopamine-related gene effects on caudate volume in young and elderly populations (N1198) using genome-wide search. Mol Psychiatry 16(9):927–937. https://doi.org/10.1038/mp.2011.32
Trautmann S, Rehm J, Wittchen H (2016) The economic costs of mental disorders. EMBO Rep 17(9):1245–1249. https://doi.org/10.15252/embr.201642951
Van Leemput K, Bakkour A, Benner T et al (2009) Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRI. Hippocampus 19(6):549–557. https://doi.org/10.1002/hipo.20615
Vigo D, Thornicroft G, Atun R (2016) Estimating the true global burden of mental illness. Lancet Psychiatry 3(2):171–178. https://doi.org/10.1016/S2215-0366(15)00505-2
Whiteford HA, Degenhardt L, Rehm J et al (2013) Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet 382(9904):1575–1586. https://doi.org/10.1016/S0140-6736(13)61611-6
Williams EG, Auwerx J (2015) The convergence of systems and reductionist approaches in complex trait analysis. Cell 162(1):23–32. https://doi.org/10.1016/j.cell.2015.06.024
Woods KS, Doss CC, Bowyer KW, Solka JL, Priebe CE, Jr WPK (1993) Comparative evaluation of pattern recognition techniques for detection of microcalcifications in mammography. Int J Pattern Recognit Artif Intell 7(6):1417–1436
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Cao, B., Reilly, J. (2019). Major Challenges and Limitations of Big Data Analytics. In: Passos, I., Mwangi, B., Kapczinski, F. (eds) Personalized Psychiatry. Springer, Cham. https://doi.org/10.1007/978-3-030-03553-2_2
Download citation
DOI: https://doi.org/10.1007/978-3-030-03553-2_2
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-03552-5
Online ISBN: 978-3-030-03553-2
eBook Packages: MedicineMedicine (R0)