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Molecular Biology of KSHV in Relation to HIV/AIDS-Associated Oncogenesis

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HIV/AIDS-Associated Viral Oncogenesis

Part of the book series: Cancer Treatment and Research ((CTAR,volume 177))

Abstract

Discovered in 1994, Kaposi’s sarcoma-associated herpesvirus (KSHV) has been associated with four human malignancies including Kaposi’s sarcoma, primary effusion lymphoma, a subset of multicentric Castleman’s disease, and KSHV inflammatory cytokine syndrome. These malignancies mostly occur in immunocompromised patients including patients with acquired immunodeficiency syndrome and often cause significant mortality because of the lack of effective therapies. Significant progresses have been made to understand the molecular basis of KSHV infection and KSHV-induced oncogenesis in the last two decades. This chapter provides an update on the recent advancements focusing on the molecular events of KSHV primary infection, the mechanisms regulating KSHV life cycle, innate and adaptive immunity, mechanism of KSHV-induced tumorigenesis and inflammation, and metabolic reprogramming in KSHV infection and KSHV-transformed cells.

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Authors and Affiliations

  1. Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, USA

    Meilan He, Fan Cheng, Suzane Ramos da Silva, Brandon Tan, Océane Sorel, Marion Gruffaz, Tingting Li & Shou-Jiang Gao

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  1. Meilan He
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  2. Fan Cheng
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  1. Penn State Cancer Institute, Penn State University, Hershey, PA, USA

    Craig Meyers

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He, M. et al. (2019). Molecular Biology of KSHV in Relation to HIV/AIDS-Associated Oncogenesis. In: Meyers, C. (eds) HIV/AIDS-Associated Viral Oncogenesis. Cancer Treatment and Research, vol 177. Springer, Cham. https://doi.org/10.1007/978-3-030-03502-0_2

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