Skip to main content

Cervical Cancer Screening in Low- and Middle-Income Countries

  • Chapter
  • First Online:
Uterine Cervical Cancer

Abstract

Population-based screening programs have reduced significantly cervical cancer burden in high-income countries over the past few decades. Low- and middle-income countries have failed to show a major impact on cervical cancer control, even in settings where cytology- or visual inspection-based screening activities are ongoing. Widespread use of HPV vaccine is the most promising strategy to avoid disease development. Nevertheless, a vaccine population-based approach is still limited to some settings, and the impact of mass vaccination is not expected for some time. In 2016 the American Society of Clinical Oncology issued a stratified guideline addressing global resources disparities. The goal of this chapter is to debate challenges from low- and middle-income countries to implement successful cervical cancer screening programs in order to reduce cancer burden. The feasibility for introduction of new technologies, like the HPV-DNA-based tests, will be analyzed according to the different scenarios. This intends to be a critical review addressing aspects of organization of screening programs in the view of global disparities.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray, F. GLOBOCAN 2012 v1.0, Cancer incidence and mortality worldwide: IARC CancerBase No. 11 [Internet]. 2013 [cited 2016 Dec 9]. http://globocan.iarc.fr/Default.aspx

  2. Bray F, Jemal A, Grey N, Ferlay J, Forman D. Global cancer transitions according to the Human Development Index (2008–2030): a population-based study. Lancet Oncol. 2012;13(8):790–801.

    Article  Google Scholar 

  3. Forouzanfar MH, Foreman KJ, Delossantos AM, Lozano R, Lopez AD, Murray CJL, et al. Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet Lond Engl. 2011;378(9801):1461–84.

    Article  Google Scholar 

  4. World Bank. How does the World Bank classify countries? – World Bank Data Help Desk [Internet]. [cited 2017 Jun 24]. https://datahelpdesk.worldbank.org/knowledgebase/articles/378834-how-does-the-world-bank-classify-countries

  5. American Society of Clinical Oncology. New cervical cancer guideline addresses global resource disparities [Internet]. ASCO. 2016 [cited 2017 Jun 24]. https://www.asco.org/about-asco/press-center/news-releases/new-cervical-cancer-guideline-addresses-global-resource

  6. United Nations. Sustainable development goals: 17 goals to transform our world [Internet]. United Nations Sustainable Development. [cited 2017 Jun 24]. http://www.un.org/sustainabledevelopment/

  7. Arbyn M, Raifu AO, Weiderpass E, Bray F, Anttila A. Trends of cervical cancer mortality in the member states of the European Union. Eur J Cancer. 2009;45(15):2640–8.

    Article  Google Scholar 

  8. Lăără E, Day NE, Hakama M. Trends in mortality from cervical cancer in the Nordic countries: association with organised screening programmes. Lancet. 1987;1(8544):1247–9.

    Article  Google Scholar 

  9. Peto J, Gilham C, Fletcher O, Matthews FE. The cervical cancer epidemic that screening has prevented in the UK. Lancet. 2004;364(9430):249–56.

    Article  Google Scholar 

  10. Murillo R, Almonte M, Pereira A, Ferrer E, Gamboa OA, Jerónimo J, et al. Cervical cancer screening programs in Latin America and the Caribbean. Vaccine. 2008;26:L37–48.

    Article  Google Scholar 

  11. Ponti A, et al. Cancer screening in the European Union: second report on implementation [Internet]. [cited 2017 Apr 24]. https://ec.europa.eu/health/sites/health/files/major_chronic_diseases/docs/2017_cancerscreening_2ndreportimplementation_en.pdf

  12. Walsh B, Silles M, O’Neill C. The importance of socio-economic variables in cancer screening participation: a comparison between population-based and opportunistic screening in the EU-15. Health Policy Amst Neth. 2011;101(3):269–76.

    Article  Google Scholar 

  13. Adab P, McGhee SM, Yanova J, Wong CM, Hedley AJ. Effectiveness and efficiency of opportunistic cervical cancer screening: comparison with organized screening. Med Care. 2004;42(6):600–9.

    Article  Google Scholar 

  14. do Vale DBAP, Morais SS, Pimenta AL, Zeferino LC. Assessment of the cervical cancer screening in the Family Health Strategy in Amparo, São Paulo State, Brazil. Cad Saude Publica. 2010;26(2):383–90.

    Article  Google Scholar 

  15. Palència L, Espelt A, Rodríguez-Sanz M, Puigpinós R, Pons-Vigués M, Pasarín MI, et al. Socio-economic inequalities in breast and cervical cancer screening practices in Europe: influence of the type of screening program. Int J Epidemiol. 2010;39(3):757–65.

    Article  Google Scholar 

  16. Miller AB, Nazeer S, Fonn S, Brandup-Lukanow A, Rehman R, Cronje H, et al. Report on consensus conference on cervical cancer screening and management. Int J Cancer. 2000;86(3):440–7.

    Article  CAS  Google Scholar 

  17. Sankaranarayanan R, Gaffikin L, Jacob M, Sellors J, Robles S. A critical assessment of screening methods for cervical neoplasia. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet. 2005;89(Suppl 2):S4–12.

    Article  Google Scholar 

  18. International Agency for Research on Cancer. IARC handbooks of cancer prevention: cervix cancer screening. Vol. 10. IARC; 2005.

    Google Scholar 

  19. Rozemeijer K, Naber SK, Penning C, Overbeek LIH, Looman CWN, de Kok IMCM, et al. Cervical cancer incidence after normal cytological sample in routine screening using SurePath, ThinPrep, and conventional cytology: population based study. BMJ. 2017;356:j504.

    Article  Google Scholar 

  20. Rozemeijer K, Penning C, Siebers AG, Naber SK, Matthijsse SM, van Ballegooijen M, et al. Comparing SurePath, ThinPrep, and conventional cytology as primary test method: SurePath is associated with increased CIN II+ detection rates. Cancer Causes Control. 2016;27(1):15–25.

    Article  Google Scholar 

  21. Sankaranarayanan R, Nessa A, Esmy PO, Dangou J-M. Visual inspection methods for cervical cancer prevention. Best Pract Res Clin Obstet Gynaecol. 2012;26(2):221–32.

    Article  Google Scholar 

  22. WHO. Guidelines for screening and treatment of precancerous lesions for cervical cancer prevention [Internet]. WHO. [cited 2015 Aug 11]. http://www.who.int/reproductivehealth/publications/cancers/screening_and_treatment_of_precancerous_lesions/en/

  23. Ronco G, Giorgi-Rossi P, Carozzi F, Confortini M, Dalla Palma P, Del Mistro A, et al. Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial. Lancet Oncol. 2010;11(3):249–57.

    Article  CAS  Google Scholar 

  24. Rijkaart DC, Berkhof J, Rozendaal L, van Kemenade FJ, Bulkmans NWJ, Heideman DAM, et al. Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial. Lancet Oncol. 2012;13(1):78–88.

    Article  Google Scholar 

  25. Castle PE, Stoler MH, Wright TC, Sharma A, Wright TL, Behrens CM. Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a subanalysis of the ATHENA study. Lancet Oncol. 2011;12(9):880–90.

    Article  Google Scholar 

  26. Sankaranarayanan R, Nene BM, Shastri SS, Jayant K, Muwonge R, Budukh AM, et al. HPV screening for cervical cancer in rural India. N Engl J Med. 2009;360(14):1385–94.

    Article  CAS  Google Scholar 

  27. Khan MJ, Castle PE, Lorincz AT, Wacholder S, Sherman M, Scott DR, et al. The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice. J Natl Cancer Inst. 2005;97(14):1072–9.

    Article  Google Scholar 

  28. Dillner J, Rebolj M, Birembaut P, Petry K-U, Szarewski A, Munk C, et al. Long term predictive values of cytology and human papillomavirus testing in cervical cancer screening: joint European cohort study. BMJ. 2008;337:a1754.

    Article  Google Scholar 

  29. Jeronimo J, Bansil P, Lim J, Peck R, Paul P, Amador JJ, et al. A multicountry evaluation of careHPV testing, visual inspection with acetic acid, and Papanicolaou testing for the detection of cervical cancer. Int J Gynecol Cancer. 2014;24(3):576–85.

    Article  Google Scholar 

  30. Zhao F-H, Lewkowitz AK, Chen F, Lin MJ, Hu S-Y, Zhang X, et al. Pooled analysis of a self-sampling HPV DNA test as a cervical cancer primary screening method. J Natl Cancer Inst. 2012;104(3):178–88.

    Article  Google Scholar 

  31. Gök M, van Kemenade FJ, Heideman DAM, Berkhof J, Rozendaal L, Spruyt JWM, et al. Experience with high-risk human papillomavirus testing on vaginal brush-based self-samples of non-attendees of the cervical screening program. Int J Cancer. 2012;130(5):1128–35.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Diama Bhadra Vale .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Vale, D.B., Bragança, J.F., Zeferino, L.C. (2019). Cervical Cancer Screening in Low- and Middle-Income Countries. In: Farghaly, S. (eds) Uterine Cervical Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-02701-8_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-02701-8_4

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-02700-1

  • Online ISBN: 978-3-030-02701-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics