Skip to main content
SpringerLink
Log in

Polysaccharides in Medical Applications

  • Chapter
  • First Online:
Bioactive Functionalisation of Silicones with Polysaccharides

Part of the book series: SpringerBriefs in Molecular Science ((BRIEFSBP))

  • 329 Accesses

Abstract

Polysaccharides are the most important organic raw materials, building blocks in several fields and machineries of life [1]. Since the 1980s, naturally occurring polysaccharides, represented by cellulose, have been re-evaluated as outstanding chemicals and/or materials with various uses. Natural polysaccharides from different sources exhibit some special characteristics at the molecular and supramolecular levels, which are associated with their hydrogen-bonding ability, side-group reactivity, which can be modified covalently or by ionic bonds, enzymatic degradability, chirality, semi-rigidity, etc.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. P. Berlin, D. Klemm, J. Tiller, R. Rieseler, A novel soluble aminocellulose derivative type: its transparent film-forming properties and its efficient coupling with enzyme proteins for biosensors. Macromol. Chem. Phys. 201, 2070–2082 (2000). https://doi.org/10.1002/1521-3935(20001001)201:15%3c2070:AID-MACP2070%3e3.0.CO;2-E

    Article  CAS  Google Scholar 

  2. S. Dumitriu (ed.), Polysaccharides in Medicinal Applications (Marcel Dekker Inc., New York, 1996)

    Google Scholar 

  3. V. Popa (ed.), Polysaccharides in Medicinal and Pharmaceutical Applications (Smithers Rapra Technology, 2011)

    Google Scholar 

  4. S. Chudzik, Natural Biodegradable Polysaccharide Coatings for Medical Articles (W.I.P. Organization, 2005)

    Google Scholar 

  5. A. Basu, K.R. Kunduru, E. Abtew, A.J. Domb, Polysaccharide-based conjugates for biomedical applications. Bioconjug. Chem. 26, 1396–1412 (2015). https://doi.org/10.1021/acs.bioconjchem.5b00242

    Article  CAS  Google Scholar 

  6. P. Mandal, C.A. Pujol, E.B. Damonte, T. Ghosh, B. Ray, Xylans from Scinaia hatei: structural features, sulfation and anti-HSV activity. Int. J. Biol. Macromol. 46, 173–178 (2010). https://doi.org/10.1016/j.ijbiomac.2009.12.003

    Article  CAS  Google Scholar 

  7. H. Fasl, J. Stana, D. Stropnik, S. Strnad, K. Stana-Kleinschek, V. Ribitsch, Improvement of the hemocompatibility of PET surfaces using different sulphated polysaccharides as coating materials. Biomacromolecules 11, 377–381 (2010). https://doi.org/10.1021/bm9010084

    Article  CAS  Google Scholar 

  8. A. Salam, J.J. Pawlak, R.A. Venditti, K. El-tahlawy, Incorporation of carboxyl groups into xylan for improved absorbency. Cellulose 18, 1033–1041 (2011). https://doi.org/10.1007/s10570-011-9542-y

    Article  CAS  Google Scholar 

  9. Y. Nishio, Material Functionalization of Cellulose and Related Polysaccharides via Diverse Microcompositions (Springer, Berlin, 2006)

    Book  Google Scholar 

  10. G. Kogan, L. Šoltés, R. Stern, P. Gemeiner, Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications. Biotechnol. Lett. 29, 17–25 (2007). https://doi.org/10.1007/s10529-006-9219-z

    Article  CAS  Google Scholar 

  11. M.J. Franklin, D.E. Nivens, J.T. Weadge, P.L. Howell, Biosynthesis of the Pseudomonas aeruginosa extracellular polysaccharides, alginate, Pel, and Psl. Front. Microbiol. 2, 167 (2011). https://doi.org/10.3389/fmicb.2011.00167

    Article  Google Scholar 

  12. S.U. Shen (ed.), Pullulan Films and Their Use in Edible Packaging (W.I.P. Organization, 2007)

    Google Scholar 

  13. M.N.V. Ravi Kumar, A review of chitin and chitosan applications. React. Funct. Polym. 46, 1–27 (2000). https://doi.org/10.1016/S1381-5148(00)00038-9

    Article  Google Scholar 

  14. R. Ahvenainen, Active and intelligent packaging: an introduction, in Novel Food Packaging Techniques (Woodhead Publishing Limited, 2003)

    Google Scholar 

  15. E. Shalaby (ed.), Biological Activities and Application of Marine Polysaccharides (InTech Open, 2017)

    Google Scholar 

  16. A. Doliška, S. Strnad, J. Stana, E. Martinelli, V. Ribitsch, K. Stana-Kleinschek, In vitro haemocompatibility evaluation of PET surfaces using the quartz crystal microbalance technique. J. Biomater. Sci. Polym. Ed. 23, 697–714 (2012). https://doi.org/10.1163/092050611X559232

    Article  CAS  Google Scholar 

  17. M. Gericke, A. Doliška, J. Stana, T. Liebert, T. Heinze, K. Stana-Kleinschek, Semi-synthetic polysaccharide sulfates as anticoagulant coatings for PET, 1 - cellulose sulfate. Macromol. Biosci. 11, 549–556 (2011). https://doi.org/10.1002/mabi.201000419

    Article  CAS  Google Scholar 

  18. D. Stephan, P. Katrin, K. Manuela, B. Anja, S.U. Suhubert, H. Thomas, Homogeneous sulfation of xylan from different sources. Macromol. Mater. Eng. 296, 551–561 (2011). https://doi.org/10.1002/mame.201000390

    Article  CAS  Google Scholar 

  19. T. Indest, J. Laine, L.-S. Johansson, K. Stana-Kleinschek, S. Strnad, R. Dworczak, V. Ribitsch, Adsorption of fucoidan and chitosan sulfate on chitosan modified PET films monitored by QCM-D. Biomacromol 10, 630–637 (2009). https://doi.org/10.1021/bm801361f

    Article  CAS  Google Scholar 

  20. S. Sanyasi, R.K. Majhi, S. Kumar, M. Mishra, A. Ghosh, M. Suar, P.V. Satyam, H. Mohapatra, C. Goswami, L. Goswami, Polysaccharide-capped silver Nanoparticles inhibit biofilm formation and eliminate multi-drug-resistant bacteria by disrupting bacterial cytoskeleton with reduced cytotoxicity towards mammalian cells. Sci. Rep. 6, 1–16 (2016). https://doi.org/10.1038/srep24929

    Article  Google Scholar 

  21. F. Sarei, N.M. Dounighi, H. Zolfagharian, P. Khaki, S.M. Bidhendi, Alginate nanoparticles as a promising adjuvant and vaccine delivery system. Indian J. Pharm. Sci. 75, 442–449 (2013). https://doi.org/10.4103/0250-474X.119829

    Article  CAS  Google Scholar 

  22. F. Wang, S. Yang, J. Yuan, Q. Gao, C. Huang, Effective method of chitosan-coated alginate nanoparticles for target drug delivery applications. J. Biomater. Appl. 31, 3–12 (2016). https://doi.org/10.1177/0885328216648478

    Article  CAS  Google Scholar 

  23. Y. Wang, X. Wang, J. Shi, R. Zhu, J. Zhang, Z. Zhang, D. Ma, Y. Hou, F. Lin, J. Yang, M. Mizuno, A biomimetic silk fibroin/sodium alginate composite scaffold for soft tissue engineering. Sci. Rep. 6, 1–13 (2016). https://doi.org/10.1038/srep39477

    Article  CAS  Google Scholar 

  24. J.C. Courtenay, M.A. Johns, F. Galembeck, C. Deneke, E.M. Lanzoni, C.A. Costa, J.L. Scott, R.I. Sharma, Surface modified cellulose scaffolds for tissue engineering. Cellulose 24, 253–267 (2017). https://doi.org/10.1007/s10570-016-1111-y

    Article  CAS  Google Scholar 

  25. M. Finšgar, A.P. Uzunalić, J. Stergar, L. Gradišnik, U. Maver, Novel chitosan/diclofenac coatings on medical grade stainless steel for hip replacement applications. Sci. Rep. 6, 1–17 (2016). https://doi.org/10.1038/srep26653

    Article  CAS  Google Scholar 

  26. T. Ristić, A. Zabret, L.F. Zemljič, Z. Peršin, Chitosan nanoparticles as a potential drug delivery system attached to viscose cellulose fibers. Cellulose 24, 739–753 (2017). https://doi.org/10.1007/s10570-016-1125-5

    Article  CAS  Google Scholar 

  27. M. Bračič, L. Fras-Zemljič, L. Pérez, K. Kogej, K. Stana-Kleinschek, R. Kargl, T. Mohan, Protein-repellent and antimicrobial nanoparticle coatings from hyaluronic acid and a lysine-derived biocompatible surfactant. J. Mater. Chem. B. 5, 3888–3897 (2017). https://doi.org/10.1039/C7TB00311K

    Article  Google Scholar 

  28. C.L. Romanò, S. Scarponi, E. Gallazzi, D. Romanò, L. Drago, Antibacterial coating of implants in orthopaedics and trauma: a classification proposal in an evolving panorama. J. Orthop. Surg. Res. 10, 157 (2015). https://doi.org/10.1186/s13018-015-0294-5

    Article  Google Scholar 

  29. G. Scott (ed.), Degradable Polymers: Principles and Applications, 2nd edn. (Springer, Netherlands, 2002)

    Google Scholar 

  30. F. Iolanda, D. Gianfranco, Prevention and control of biofilm-based medical-device-related infections. FEMS Immunol. Med. Microbiol. 59, 227–238 (2010). https://doi.org/10.1111/j.1574-695X.2010.00665.x

    Article  CAS  Google Scholar 

  31. S. Strnad, N. Velkova, B. Saake, A. Doliška, M. Bračič, L.F. Zemljič, Influence of sulfated arabino- and glucuronoxylans charging-behavior regarding antithrombotic properties. React. Funct. Polym. 73, 1639–1645 (2013). https://doi.org/10.1016/j.reactfunctpolym.2013.09.007

    Article  CAS  Google Scholar 

  32. E. Karbassi, A. Asadinezhad, M. Lehocký, P. Humpolíček, A. Vesel, I. Novák, P. Sáha, Antibacterial performance of alginic acid coating on polyethylene film. Int. J. Mol. Sci. 15, 14684–14696 (2014). https://doi.org/10.3390/ijms150814684

    Article  CAS  Google Scholar 

  33. S.B. Goodman, Z. Yao, M. Keeney, F. Yang, The future of biologic coatings for orthopaedic implants. Biomaterials 34, 3174–3183 (2013). https://doi.org/10.1016/j.biomaterials.2013.01.074

    Article  CAS  Google Scholar 

  34. T. Ristić, S. Hribernik, L. Fras-Zemljič, Electrokinetic properties of fibres functionalised by chitosan and chitosan nanoparticles. Cellulose 22, 3811–3823 (2015). https://doi.org/10.1007/s10570-015-0760-6

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculty of Mechanical Engineering, University of Maribor, Maribor, Slovenia

    Matej Bračič, Prof. Dr. Simona Strnad & Lidija Fras Zemljič

Authors
  1. Matej Bračič
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Prof. Dr. Simona Strnad
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lidija Fras Zemljič
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Matej Bračič .

Rights and permissions

Reprints and permissions

Copyright information

© 2018 The Author(s), under exclusive licence to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Bračič, M., Strnad, S., Fras Zemljič, L. (2018). Polysaccharides in Medical Applications. In: Bioactive Functionalisation of Silicones with Polysaccharides. SpringerBriefs in Molecular Science(). Springer, Cham. https://doi.org/10.1007/978-3-030-02275-4_3

Download citation

Publish with us

Policies and ethics

Search

Navigation