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Dietary Components and Immune Function pp 553–565Cite as

Cinnamon and Immune Actions: Potential Role in Tristetraprolin-Mediated Inflammatory Diseases

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Key Points

Inflammatory diseases place a heavy burden on the American health care system. Tristetraprolin, a zinc-dependent mRNA binding protein decreases the stability of mRNAS coding for some proinflammatory cytokines. Tristetraprolin-deficient mice develop a profound inflammatory syndrome. Tristetraprolin is a potential cancer therapy due to its control of vascular endothelial growth factor mRNA stability. Cinnamon extract stimulates the expression of antiinflammatory tristetraprolin. Bioactive compound(s) in cinnamon extract define its molecular mechanisms. Cinnamon is potentially important in tristetraprolin-mediated inflammatory diseases.

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Authors and Affiliations

  1. US Department of Agriculture, Commodity Utilization Research Unit, Southern Regional Research Center, Agricultural Research Service, 1100 Robert E. Lee Blvd, New Orleans, LA, 70124, USA

    Heping Cao

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  1. Heping Cao
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Correspondence to Heping Cao .

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Editors and Affiliations

  1. Health Sciences Center, Department of Health Promotion Sciences, University of Arizona, 1295 N. Martin Ave. 1295, Tucson, 85724-5155, USA

    Ronald Ross Watson

  2. Mel & Enid Zuckerman College of, Public Health, University of Arizona, Tucson, 85724-5163, USA

    Sherma Zibadi

  3. Dept. Nutrition & Dietetics, King's College, Stamford St. 150, London, SE1 9NH, United Kingdom

    Victor R. Preedy

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Cao, H. (2010). Cinnamon and Immune Actions: Potential Role in Tristetraprolin-Mediated Inflammatory Diseases. In: Watson, R., Zibadi, S., Preedy, V. (eds) Dietary Components and Immune Function. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-061-8_30

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  • DOI: https://doi.org/10.1007/978-1-60761-061-8_30

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