Abstract
Coronaviruses were classified as a distinct group of viruses in 19681 and are now recognized as the etiologic agents of an increasing number of diseases of man and animals2–7. At least four members of the group are human respiratory pathogens. Others have been suggested to be involved in neurologic and enteric disease processes in man, although none of these strains have yet been isolated in the true sense of the word.8–18 Respiratory strain B814 was the first human coronavirus discovered, having been isolated in human embryonic tracheal organ culture by Tyrrell & Bynoe in 1960.19 Strain 229E was recovered in secondary human fetal kidney cell cultures by Hamre & Procknow in 1962.20 Strain OC-43 and many related strains were then found by organ culture techniques in 1966 by McIntosh et al.21 Strain 692 was identified by immune electron microscopy in 1966 by Kapikian et al.22
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Hierholzer, J.C., Kemp, M.C., Tannock, G.A. (1981). The RNA and Proteins of Human Coronaviruses. In: ter Meulen, V., Siddell, S., Wege, H. (eds) Biochemistry and Biology of Coronaviruses. Advances in Experimental Medicine and Biology, vol 142. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0456-3_4
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