Abstract
Many lines of evidence are pointing toward a role of the excitatory amino acid transmitters and their receptors in the mechanisms leading to epileptic seizure disorders. Various excitatory amino acids and structural analogs, such as kainic acid, quinolinic acid or ibotenic acid, initiate epilepticlike discharges when applied to nervous tissue (Ben-Ari et al.,1979; French et al.,1982; Schwarcz et al., 1984). Changes in excitatory amino acid content in cerebral tissue and cerebrospinal fluid have been reported to occur in various animal models and human epileptic conditions (Van Gelder et al., 1972; Morselli et al., 1981).Most convincing are the potent anticonvulsanteffects of D-2-amino-7-phosphonoheptanoic acid (AP-7), a specific N-methyl-D-aspartic acid (NMDA) receptor antagonist, in several animal models of epilepsy (Croucher et al.,1982; Meldrum et al., 1983).
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References
Baba, A., Yamagami, S., Mizuo, H., and Iwata, H., 1980, Microassay of cysteine sulfinic acid by an enzymatic cycling method, Anal. Biochem. 101:288.
Baba, A., Okumura, S., Mizuo, H., and Iwata, H., 1983, Inhibition by diazepam and y-aminobutyric acid Qf depolarization-induced release of [14C] cysteine sulfinate and [H]glutamate in rat hippocampal slices,J. Neurochem. 40:280.
Baudry, M., Kramer, K., Fagni, L., Recasens, M., and Lynch, G., 1983, Classification and properties of acidic amino acid receptors in hippocampus, Mol. Pharmacol. 24:222.
Ben-Ari, Y., Lagowska, J., Tremblay, E., and Le Gal La Salle G., 1979, A new model of focal status epilepticus: intraamygdaloid application of kainic acid elicits repetitive secondarily generalized convulsive seizures, Brain Res. 163: 176.
Chang, J.-Y, 1981, Isolation and characterization of polypeptide at the picomole level, Biochem. J. 199:537.
Collingridge, G.L., Kehl, S.J., and McLennan, H., 1983, Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus, J. Physiol. 334:33.
Cox, D.W.G., Headley, M.H., and Watkins, J.C., 1977, Actions of L- and D-homocysteate in rat CNS: a correlation between low-affinity uptake and the time courses of excitation by microelectrophoretically applied L-glutamate analogues, J. Neurochem. 29:579.
Croucher, M.J., Collins, J.F., and Meldrum, B.S., 1982, Anticonvulsant action of excitatory amino acid antagonist, Science 216: 899.
Cuénod, M., Bagnoli, P., Beaudet, A., Rustioni, A., Wiklund, L., and Streit, P., 1982, Transmitter specific retrograde labeling of neurons,in: Cytochemical Methods in Neuroanatomv V. Chan-Palay and S. L. Palay,Alan R. Liss, Inc., New York, P. 17.
Cuénod, M., and Streit, P., 1983, Neuronal tracing using retrograde migration of labeled transmitter-related compounds, in: Methods in Chemical. Neuroanatomv A. Björklund and T. Hökfelt,Elsevier, Amsterdam,p. 365.
Cuénod, M., Do, K.Q., Matute, C., and Streit, P., 1986, Identification of pathways for acidic amino acid transmitters and search for new candidates: sulphur containing amino acids, in: Excitatory Amino Acids P.J. Roberts, J. Storm-Mathisen and H.F. Bradford,Macmillan Press, London, in press.
Curtis, D.R., and Watkins, J.C., 1960, The excitation and depression of spinal neurones by structurally related amino acids, J. Neurochem. 6:117.
Dempsey, E.W., and Morison, R.S., 1942a, The production of rhythmically recurrent cortical potentials after localized thalamic stimulation, Amer. J. Phvsiol. 135:293.
Dempsey, E.W., and Morison, R.S., 1942b, The interaction of certain spontaneous and induced cortical potentials, Amer. J. Physiol. 135:301.
Do, K.Q., Mattenberger, M., Streit, P., and Cuênod, M. 1986a, In vitro release of endogenous excitatory sulphur containing amino acids from various rat brain regions, J, Neurochem. 46:779.
Do, K.Q., Herrling, P.L., Streit, P., Turski, W.A., and Cuénod, M. 1986b, In vitro release and electrophysiological effects in situ of homocysteic acid, an endogenous N-methyl-D-aspartic acid agonist, inthe mammalian striatum, J. Neurosci. in press.
Evans, R.H., Francis, A.A., Jones, A.W., Smith, D.A.S., and Watkins, J.C., 1982, The effects of a series of omegaphosphonic alpha-carboxylic amino acid-induced responses in the isolated spinal cord preparation, Br. J, Pharmac. 75:65.
Fonnum, F., Ureide, A., Kvale, I., Walker, J., and Walaas, I., 1981, Glutamate in cortical fibers, in: Glutamate as a Neurotransmitter G. DiChiara and G.L. Gessa,Raven Press, New York, p. 29.
French, E.D, Aldinio, C., and Schwarcz, R., 1982, Intrahippocampal kainic acid, seizures and local neuronal degeneration: relationships assessed in unanesthetized rats, Neuroscience 7: 2525.
Hanberry, J., and Jasper, H.H., 1953, Independence of diffuse thalamic projection system shown by specific nuclear destructions, J. Neurophysiol. 16:252.
Harris, E.W., Ganong, A.H., and Cotman, C.W., 1984, Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors, Brain Res t323: 132.
Herkenham, M., 1980, Laminar organization of thalamic projections to the rat cortex, Science 207: 532.
Herrling, P.L., Morris, R., and Salt, T.E., 1983, Effects of excitatory amino acids and their antagonists on membrane and action potentials of cat caudate neurones, J, Phvsiol. 339:207.
Herrling, P.L., 1985, Pharmacology of the corticocaudate excitatory post-synaptic potential in the cat: evidence for its mediation by quisqualate- or kainate-receptors, Neuroscience 14:417.
Herrling, P.L., and Turski, W.A., 1986 Interactions of sulphur-containing excitatory amino acids with membrane and synaptic potentials of cat caudate neurons, in: Excitatory Amino Acids P.J. Roberts, J. StormMathisen and H.F. Bradford,Macmillan Press, London, in press.
Ida, S., and Kuriyama, K., 1983, Simultaneous determination of cysteine sulfinic acid and cysteic acid in rat brain by high-performance liquid chromatography, Anal. Biochem. 130:95.
Iwata, H., Yamagami, S., Mizuo, H., and Baba, H., 1982, Cysteine sulfinic acid in the central nervous system: uptake and release of cysteine sulfinic acid by a rat brain preparation, J. Neurochem. 38:1268.
Jasper, H.H., 1960, Unspecific thalamocortical relations, in: Handbook of Physiology: Neurophysiology J. Field, H.W. Magoun and V.E. Hall,American Physiological Society, Washington, p. 1307.
Lambert, J.D.C., Flatman, J.A., and Engberg, I., 1981, Actions of excitatory amino acids on membrane conductance and potential in motoneurones,in: Glutamate as a Neurotransmitter G. DiChiara and G.L. Gessa,Raven Press, New York, p. 205.
Luini, A., Goldberg, O., and Teichberg, V.I., 1984, An evaluation of selected brain constituants as putative excitatory neurotransmitters, Brain Res., 324: 271.
Mayer, M.L., and Westbrook, G.L., 1984, Mixed-agonist action of excitatory amino acids on mouse spinal cord neurones under voltage clamp,J. Physiol. 354:29.
Mayer, M.L., and Westbrook, G.L., 1985, The action of N-methyl-D-aspartic acid on mouse spinal neurones in culture, J. Physiol. 361:65.
Meldrum, B.S., Croucher, M.J., Badman, G., and Collins, J.F., 1983, Anti-epileptic action of excitatory amino acid antagonists in photosensitive baboon, Papio papio, Neurosci. Lett. 39:101.
Mewett, K.N., Oakes, D.J., Olverman, H.J., Smith, D.A.S., and Watkins, J.C., 1983, Pharmacology of the excitatory actions of sulphonic and sulphinic amino acids, in: CNS Receptors - From Molecular Pharmacology to Behavior P. Mandel and F.V. DeFeudis,Raven Press, New York, p. 163.
Monaghan, D.T., mnd Cotman, C.W., 1985, Distribution of N-methyl-D-aspartate- sensitive L-(H]Glutamate-binding sites in rat brain, J. Neurosci.in press.
Morison, R.S., and Dempsey, E.W., 1942, A study of thalamo-cortical relations, Amer. J. Physiol. 135:281.
Morselli, P.L., Lloyd, K.G., Löscher, W., Meldrum, B., and Reynolds, E.H., 1981, Neurotransmitters, Seizures and Epilepsy Raven Press,New York.
Mudd, S.H., and Levy, H.L., 1983, Disorders of transsulfuration, in: The Metabolic Basis of Inherited Diseases J.B. Stanbury, J.B. Wyngaarden, D.S. Fredrickson, J.L. Goldstein and M.S. Brown,McGraw-Hill, New York, p. 522.
Ottersen, O.P., Fisher, B.O., and Storm-Mathisen, J., 1983, Retrograde transport of D-[H]aspartate in thalamo-cortical neurones, Neurosci. Lett. 42:19.
Perkins, M.N., Collins, J.F., and Stone, T.W., 1982, Isomeres of 2-amino-7phosphonoheptanoic acid as antagonists of neural excitants, Neurosci. Lett. 32:65.
Purpura, D.P., 1959, Nature of electrocortical potentials and synaptic organizations in cerebral and cerebellar cortex, in: International Review of Neurobiology C.C. Pfeiffer and J.R. Smythies,Academic Press, New York, p. 47.
Purpura, D.P., and Shofer, R.J., 1964, Cortical intracellular potentials during augmenting and recruiting responses. I. Effects of injected hyperpolarizing currents on evoked membrane potential changes,J. Neurophvsiol. 27:117.
Purpura, D.P., Shofer, R.J., and Musgrave, F.S., 1964, Cortical intracellular potentials during augmenting and recruiting responses. H. Patterns of synaptic activities in pyramidal and nonpyramidal tract neurons, J. Neurophvsiol. 27:133.
Recasens, M., Varga, V., Nanopoulos, D., Saadoun, F., Vincendon, G., and Benavides, J., 1982, Evidence for cysteine sulfinate as a neurotransmitter, Brain Res. 239: 153.
Recasens, M., Saadoun, F., Varga, V., DeFeudis, F.V., Mandel, P., Lynch, G., and Vincendon, G., 1983, Separate binding sites in rat brain synaptic membranes for L-cysteine sulfinate and L-glutamate, Neurochem. Int. 5:89.
Recasens, M., Fagni, L., Bamdry, M., and Lynch, G., 1984. Potassium and veratrine-stimulated L-[H]cysteine sulfinate and L-[H]glutamate release from rat brain slices, Neurochem. Int. 6:325.
Schwarcz, R., Foster, A.C., French, E.D., Whetsell, W.O. Jr., and Köhler, C., 1984, Excitotoxic models for neurodegenerative disorders, Life Sci. 35: 19.
Storm-Mathisen, J., Leknes, A.K., Bore, A.T., Vaaland, J.L., Edminson, P., Haug, F.-M.S., and Ottersen, 0.P., 1983, First visualization of glutamate and GABA in neurones by immunocytochemistry, Nature 301: 517.
Streit, P., 1980, Selective retrograde labeling indicating the transmitter of neuronal pathways, J. Comp. Neurol. 191:429.
Streit, P., 1984, Glutamate and aspartate as transmitter candidates for systems of the cerebral cortex, in: Cerebral Cortex Vol. 2 E.G. Jones and A. Peters,Plenum Publ. Corp., New York, p. 119.
Van Gelder, N.M., Sherwin, A.L., and Rasmussen, T., 1972, Amino acid content of epileptogenic human brain. Focal versus surrounding regions,Brain Res. 40: 385.
Watkins, J.C., and Evans, R.H., 1981, Excitatory amino acid transmitters, Ann. Rev. Pharmacol. Toxicol. 21:165.
Wu, S.M., and Dowling, J.E., 1978, L-aspartate: evidence for a role in cone photoreceptor synaptic transmission in the carp retina, Proc. Natl, Acad. Sci. USA 75:5205.
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Cuénod, M., Do, K.Q., Herrling, P.L., Turski, W.A., Matute, C., Streit, P. (1986). Homocysteic Acid, an Endogenous Agonist of NMDA-Receptor: Release, Neuroactivity and Localization. In: Schwarcz, R., Ben-Ari, Y. (eds) Excitatory Amino Acids and Epilepsy. Advances in Experimental Medicine and Biology, vol 203. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7971-3_19
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