Skip to main content
SpringerLink
Log in
Book cover

Vasopeptides pp 399–408Cite as

A Structure-Activity Basis for Vasotropic Peptide Therapy in Shock

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 21))

Abstract

Chemical analogues which enhance one or several biologic properties of important naturally occurring substances are regularly sought. Currently in this regard, there is intense interest in developing such analogues of the neurohypophyseal hormones (NHPH), oxytocin and vasopressin. Several which have recently been synthesized not only offer the possibility of increased insight into structure-activity relationships but also may provide for more precise therapeutic drug actions (17).

This study was supported by research grants HE-12462 and HE-11391 from the National Institutes of Health, USPHS, Bethesda, Maryland.

Recipient of Research Career Development Award 5-K3-GM-38, 603 from the N.I.H., USPHS.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. B.M. Altura, “Differential actions of polypeptides and other drugs on coronary inflow vessels,” Am. Heart J., 72: 709–711, 1966.

    Article  PubMed  CAS  Google Scholar 

  2. B.M. Altura, “Evaluation of neurohumoral substances in local regulation of blood flow,” Am. J. Physiol., 212: 1447–1454, 1967.

    PubMed  CAS  Google Scholar 

  3. B.M. Altura, “Significance of amino acid residues in vasopressin on contraction in vascular muscle,” Am. J. Physiol., 219: 222–229, 1970.

    PubMed  CAS  Google Scholar 

  4. B.M. Altura, “Influence of magnesium and cysteine on vasopressininduced contractions in various canine blood vessels,” Experientia, 26: 1089–1090, 1970.

    Article  PubMed  CAS  Google Scholar 

  5. B.M. Altura, “Pharmacology of neurohypophyseal hormones and analogs on isolated vascular muscle and in the terminal vascular bed,” in: J.A. Bevan, R.F. Furchgott, R.A. Maxwell and A.P. Som I yo, Eds., Physiology and Pharmacology of Vascular Neuroeffector Systems. Basel, Karger, pp. 274–290, 1971.

    Google Scholar 

  6. B.M. Altura, “Chemical and humoral regulation of blood flow through the precapillary sphincter,” Microvascular Res., 3: October, 1971 (in press).

    Google Scholar 

  7. B.M. Altura, “Structure-activity relationships of neurohypophyseal polypeptides on different types of isolated mammalian blood vessels,” in: These Proceedings.

    Google Scholar 

  8. B.M. Altura and S.G. Hershey, “Pharmacology of neurohypophyseal hormones and their synthetic analogues in the terminal vascular bed. Structure-activity relationships,” Angiology, 18: 428–439, 1967.

    Article  PubMed  CAS  Google Scholar 

  9. B.M. Altura and S.G. Hershey, “Use of reticuloendothelial phagocytic function as an index in shock therapy,” Bull. N.Y. Acad. Med., 43: 259–266, 1967.

    PubMed  CAS  Google Scholar 

  10. B.M. Altura and S.G. Hershey, “Structure-activity relationships of neurohypophyseal polypeptides in the microcirculation: A molecular basis for shock therapy,” in: B. Schildt and L. Thorén, Eds., Intermedes Proceedings 1968: Combined Injuries and Shock. Stockholm, Almqvist and Wiksell, pp. 247–259, 1968.

    Google Scholar 

  11. B.M. Altura and S.G. Hershey, “Influence of vasopressor drugs on reticuloendothelial phagocytic function in experimental shock,” in: B. Schildt and L. Thorén, Eds., Intermedes Proceedings 1968: Combined Injuries and Shock. Stockholm, Almqvist and Wiksell, p. 185–193, 1968.

    Google Scholar 

  12. B.M. Altura and S.G. Hershey, “Structure-action relationships of vasopressin analogs in the microcirculation and their use in the treatment of experimental shock,” Federation Proc., 29: 711, 1970.

    Google Scholar 

  13. B.M. Altura, S.G. Hershey and B.T. Altura, “Microcirculatory actions of polypeptides and their use in the treatment of experimental shock,” Adv. Exptl. Med. Biol., 8: 239–247, 1970.

    CAS  Google Scholar 

  14. B.M. Altura, S.G. Hershey and V.D.B. Mazzia, “Microcirculatory approach to vasopressor therapy in intestinal ischemic (SMA) shock,” Am. J. Surgery, 111: 186–192, 1966.

    Article  CAS  Google Scholar 

  15. B.M. Altura, S.G. Hershey and B.W. Zweifach, “Effects of a synthetic analogue of vasopressin on vascular smooth muscle,” Proc. Soc. Exptl. Biol. Med., 119: 258–261, 1965.

    CAS  Google Scholar 

  16. B.M. Altura, R. Hsu, V.D.B. Mazzia and S.G. Hershey, “Influence of vasopressors on survival after traumatic, intestinal ischemia and endotoxin shock in rats,” Proc. Soc. Exptl. Biol. Med., 119: 389393, 1965.

    Google Scholar 

  17. B. Berde, Ed., “Handbook of Experimental Pharmacology, vol. 23: Neurohypophysial Hormones and Similar Polypeptides.” Berlin, Springer-Verlag, 1968.

    Google Scholar 

  18. B. Berde and R.A. Boissonnas, “Basic pharmacological properties of synthetic analogues and homologues of the neurohypophysial hormones,” in: B. Berde, Ed., Handbook of Experimental Pharmacology, vol. 23: Neurohypophysial Hormones and Similar Polypeptides. Berlin, Springer-Verlag, pp. 802–870, 1968.

    Google Scholar 

  19. B. Berde, R.A. Boissonnas, R. Huguenin and E. StUrmer, “Vasopressin analogues with selective pressor activity,” Experientia, 20: 42–44, 1964.

    Article  PubMed  CAS  Google Scholar 

  20. P. Brazeau, “Agents affecting the renal conservation of water,” in: L.S. Goodman and A. Gilman, Eds., The Pharmacological Basis of Therapeutics. New York, Macmillan, pp. 874–885, 1970.

    Google Scholar 

  21. J.N. Cohn, F.E. Tristani and I.M. Khatri, “Systemic vasoconstrictor and renal vasodilator effects of PLV-2 (Octapressin) in man,” Circulation, 38: 151–157, 1968.

    PubMed  CAS  Google Scholar 

  22. S.G. Hershey and B.M. Altura, “Behandlung des Schocks durch Beeinflussung der peripheren Zirkulation mit vasoaktiven Wirkstoffen: eine mikrozirkulatorische Basis für die Therapie,” Schweiz. Med. Wschr. 96: 1467–1471, 1516–1522, 1966 (2 parts).

    Google Scholar 

  23. S.G. Hershey, B.M. Altura and L.R. Orkin, “Therapy of intestinal ischemic (SMA) shock with vasoactive drugs,” Anesthesiology, 29: 466471, 1968.

    Google Scholar 

  24. S.G. Hershey, V.D.B. Mazzia, B.M. Altura and L. Gyure, “Effects of vasopressors on the microcirculation and on survival in hemorrhagic shock,” Anesthesiology, 26: 179–189, 1965.

    Article  PubMed  CAS  Google Scholar 

  25. M.E. Hunter and R.A. Gordon, “Laboratory and clinical studies of 2phenylalanine-8-lysine vasopressin (Octapressin),” Canad. Anaesth. Soc. J., 13: 40–45, 1966.

    Article  PubMed  CAS  Google Scholar 

  26. R.L. Katz, “Epinephrine and PLV-2: Cardiac rhythm and local vasoconstrictor effects,” Anesthesiology, 26: 619–623, 1965.

    Article  PubMed  CAS  Google Scholar 

  27. R.L. Katz and G.J. Katz, “Surgical infiltration of pressor drugs and their interaction with volatile anesthetics,” Brit. J. Anaesth., 38: 712–718, 1966.

    Article  PubMed  CAS  Google Scholar 

  28. O.V. Nielsen and N. Valentin, “Ornithine-8-vasopressin, a new vasoconstrictor used for haemostasis during operation for genital prolapse,” Acta Obstet. Gynec. Scand., 49: 45–48, 1970.

    Article  CAS  Google Scholar 

  29. K. Saameli, “The circulatory actions of the neurohypophysial hormones and similar polypeptides.” Berlin, Springer-Verlag, pp. 545–612, 1968.

    Google Scholar 

  30. H.B. Ban Dyke, K. Adamsons and S.L. Engel, “Aspects of the biochemistry and physiology of the neurohypophyseal hormones. Recent Progr. Hormone Res., 11: 1–35, 1955.

    Google Scholar 

  31. V. du Vigneaud, H.C. Lawler and E.A. Popenoe, “Enzymatic cleavage of glycinamide from vasopressin and a proposed structure for this pressor-antidiuretic hormone of the posterior pituitary,” J.Am. Chem. Soc., 75: 4880–4881, 1953.

    Article  Google Scholar 

  32. V. du Vigneaud, C.H. Ressler, J.M. Swan, C.W. Roberts, P.G. Katsoyannis and S. Gordon, “The synthesis of an octapeptide amide with the hormonal activity of oxytocin.” J. Am. Chem. Soc., 75: 4879–4880, 1953.

    Article  Google Scholar 

  33. B.W. Zweifach, “Functional Behavior of the Microcirculation.” Springfield, C.C. Thomas, 1961.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Anesthesiology and Physiology, Albert Einstein College of Medicine, Bronx, New York, 10461, USA

    Burton M. Altura & S. G. Hershey

Authors
  1. Burton M. Altura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. G. Hershey
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

  2. Department of Clinical Pharmacology, University of Florence, Florence, Italy

    F. Sicuteri

Rights and permissions

Reprints and permissions

Copyright information

© 1972 Plenum Press, New York

About this chapter

Cite this chapter

Altura, B.M., Hershey, S.G. (1972). A Structure-Activity Basis for Vasotropic Peptide Therapy in Shock. In: Back, N., Sicuteri, F. (eds) Vasopeptides. Advances in Experimental Medicine and Biology, vol 21. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7439-8_47

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-7439-8_47

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7441-1

  • Online ISBN: 978-1-4684-7439-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation