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Pathological Aspects of Brain Transport Phenomena

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Transport Phenomena in the Nervous System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 69))

Abstract

Historically the extravasation of dye compounds such as Evans blue and fluorescein as dye albumin complexes into the brain have been the oldest acceptable indicators of blood brain barrier (BBB) injury11, 12, 35. Subsequently, among radiolabeled substances3, labeled albumin has been most commonly used for the quantitative, besides the qualitative, evaluation of BBB permeability to albumin in pathological conditions35, 49. More recently, fluorescein labeled serum protein30 and horseradish peroxidase48 (MW 40,000) have been introduced as tracers for the functional assessment of BBB status under various circumstances. All of these substances have a common denominator of enabling the investigation of one of the many probable parameters of BBB permeability; namely, the passage of proteins across the membrane barrier. Another dimension was added in clarifying the selective vulnerability BBB when altered brain uptake of nutrients was demonstrated in the experimentally damaged BBB55–57. However, for years elaborate quantitative investigations of brain transport phenomenon in disease have been limited due to lack of suitable methods for such a study.

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Authors and Affiliations

  1. NINCDS, National Institutes of Health, 20014, Bethesda, Maryland, USA

    Maria Spatz & Igor Klatzo

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  1. Maria Spatz
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  2. Igor Klatzo
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Editors and Affiliations

  1. National Research Council, Rome, Italy

    Giulio Levi

  2. University of Padua Medical School, Padua, Italy

    Leontino Battistin

  3. Research Institute of Neurochemistry, New York, New York, USA

    Abel Lajtha

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© 1976 Plenum Press, New York

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Spatz, M., Klatzo, I. (1976). Pathological Aspects of Brain Transport Phenomena. In: Levi, G., Battistin, L., Lajtha, A. (eds) Transport Phenomena in the Nervous System. Advances in Experimental Medicine and Biology, vol 69. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-3264-0_35

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  • DOI: https://doi.org/10.1007/978-1-4684-3264-0_35

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