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Significance of Kinins in The Coronary Circulation

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Bradykinin and Related Kinins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 8))

Abstract

The physiological regulation of coronary flow is still a matter of dispute (Berne 1964, Schaper 1967). It has been speculated that kinins may play a major role in coronary regulation (Parrat 1964, Scholtholt et al. 1965), since they have a powerful action on the coronary system. Four different approaches were made in order to elucidate the significance of the kinin system in coronary regulation:

  1. (a)

    Use of kinin antagonists

  2. (b)

    Experimental increase of carboxypeptidase B concentration by constant intracoronary infusion

  3. (c)

    Administration of kininase inhibitors

  4. (d)

    Perfusion with a kininogen-free red cell suspension in a buffered dextran solution

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Author information

Authors and Affiliations

  1. Department of Physiology, Department of Clinical Chemistry and Clinical Biochemistry, University of Munich, Germany

    E. Bassenge, E. Werle, P. Walter & J. Holtz

Authors
  1. E. Bassenge
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  2. E. Werle
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  3. P. Walter
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  4. J. Holtz
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Editor information

Editors and Affiliations

  1. Department of Clinical Pharmacology, University of Florence, Florence, Italy

    F. Sicuteri

  2. Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, U.S.P., Sao Paulo, Brazil

    M. Rocha e Silva

  3. Department of Biochemical Pharmacology School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

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© 1970 Plenum Press, New York

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Bassenge, E., Werle, E., Walter, P., Holtz, J. (1970). Significance of Kinins in The Coronary Circulation. In: Sicuteri, F., e Silva, M.R., Back, N. (eds) Bradykinin and Related Kinins. Advances in Experimental Medicine and Biology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3198-8_19

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  • DOI: https://doi.org/10.1007/978-1-4684-3198-8_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3200-8

  • Online ISBN: 978-1-4684-3198-8

  • eBook Packages: Springer Book Archive

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