Summary
The mouse hepatitis virus strain JHM was injected intracerebrally into newborn and weanling rats. Three types of diseases were observed:
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1.
Acute panencephalitis: Almost all suckling rats became moribund within 6 days. Histologically severe panencephalitis with demyelinating foci was noticed; the foci were similar to those found in mice. Virus was easily detectable in the oligodendroglial cells and neurons both by immunofluorescence and electron microscopy. Infectious virus could be isolated.
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2.
Subacute demyelinating encephalomyelitis (SDE): Three weeks after infection of weanling rats, about 35% of the animals developed paralysis. Neuropathologically, demyelination with a striking predilection for white matter was observed in the brain stem, optic nerve and spinal cord. Virus was detectable by electron microscopy in degenerating oligodendroglial cells only, which corresponded to the results obtained by the immunofluorescent techniques. Infectious virus could be recovered.
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3.
Chronic progressive paralysis: Inoculated weanling rats without SDE developed 6 to 8 months later a slowly progressing paralysis of the legs. Hydrocephalus and myelomalacia were present. Viral “footprints” could not be detected.
Supported by the Deutsche Forschungsgemeinschaft, Schwerpunkt “Multiple Sklerose und verwandte Erkrankungen”, Az. Me 270/16.
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References
Andrews, J.M. and Gardner, M.B., Lower motor neuron degeneration associated with type C, RNA virus infection in mice: neuropathological features, J. Neuropath. Exp. Neurol. 33 (1974) 285–307.
Bailey, O.T., Pappenheimer, A.M., Cheever, F.S. and Daniels, J.B., A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin. II. Pathology, J. Exp. Med. 90 (1949) 195–212.
Dohrmann, G.J., Cervical spinal cord in experimental hydrocephalus, J. Neurosurg. 37 (1972) 538–542.
Fried, R.L., Hydrocephalus–Special Pathology. Developmental Neuropathology, Springer, Wien (1975) pp. 214–229.
Friedman, H.M., Gilden, D.H., Lief, F.S., Rorke, L.B., Santoli, D. and Koprowski, H., Hydrocephalus produced by the 6/94 virus: A parainfluenza type I isolated from multiple sclerosis brain tissue, Arch. Neurol. 32 (1975) 408–413.
Herndon, R.M., Griffin, D.E., McCormick, U. and Weiner, L.P., Mouse hepatitis virus-induced recurrent demyelination. A preliminary report, Arch. Neurol. 32 (1975) 32–35.
Johnson, R.T., Johnson, K.P. and Edmonds, J.C., Virus induced hydrocephalus: Development of aqueductal stenosis in hamsters after mumps infection, Science 157 (1967) 1066–1067.
Kersting, G. and Pette, E., Zur Pathohistologie and Pathogenese der experimentellen JHM-Virus Encephalomyelitis des Affen, Dtsch. Z. Nervenheilk. 174 (1956) 238–304.
Lampert, P.W., Sims, J.K. and Kinazeff, A.J., Mechanism of demyelination in JHM virus encephalomyelitis. Electron microscopic studies, Acta neuropath. (Berl.) 24 (1973) 76–85.
Li, C.P. and Jahnes, W.G., Hydrocephalus in suckling mice inoculated with SE polyoma virus, Virology 9 (1959) 489–492.
McLaurin, R.L., Bailey, O.T., Schurr, P.H. and Ingraham, F.D., Myelomalacia and multiple cavitations of spinal cord secondary to adhesive arachnoiditis. An experimental study, Arch. Pathol. 57 (1954) 138–146.
Nagashima, K., Wege, H. and ter Meulen, V., Corona virus induced subacute demyelinating encephalomyelitis in rats, in preparation.
Nagashima, K., Wege, H. and ter Meulen, V., Corona virus in cultured cell: ultrastructural and immunofluorescent studies on L-cell infected with JHM strain, in preparation.
Nielsen, S.L. and Baringer, J.R., Reovirus induced aqueductal stenosis in hamsters. Phase contrast and electron microscopic studies, Lab. Invest. 27 (1972) 531–537.
Solov’ev, V.N., Changes in the spinal cord in so-called spinal ossifying arachnoiditis, Arkh. Pathol. 35 (1973) 48–54.
Waksman, B.H. and Adams, R.D., Infectious leukoencephalitis. A critical comparison of certain experimental and naturally occurring viral leukoencephalitides with experimental allergic encephalomyelitis, J. Neuropath. Exp. Neurol. 21 (1962) 491–518.
Weiner, L.P., Pathogenesis of demyelination induced by a mouse hepatitis virus (JHM virus), Arch. Neurol. 28 (1973) 298–303.
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© 1978 Plenum Press, New York
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Nagashima, K., Wege, H., ter Meulen, V. (1978). Early and Late CNS-Effects of Corona Virus Infection in Rats. In: Palo, J. (eds) Myelination and Demyelination. Advances in Experimental Medicine and Biology, vol 100. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2514-7_28
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DOI: https://doi.org/10.1007/978-1-4684-2514-7_28
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