Abstract
The concept that the intraventricular cerebrospinal fluid (CSF) is derived primarily from a combination of ultrafiltration and secretion within the confines of the choroid plexus is well established,2, 9, 2, 8 although a lesser but equally important quantity of fluid is derived from an extrachoroidal source.4, 23 From an anatomical standpoint, the arrangement of large fenestrated capillaries in close approximation to an overlying ependymal sheet is ideal for the coupling of the filtration and secretory processes located within the choroid plexus (Fig. 1). The anatomical substrate for the extrachoroidal formation of fluid, however, is at present unknown.28 The sequence of events involved in the elaboration of CSF by choroid-plexus tissue is shown in Fig. 2. The first step in this process is the formation of a simple filtrate of the plasma utilizing the available net hydrostatic forces operating across the fenestrated choroidal capillaries.
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Pollay, M., Stevens, F.A., Roberts, P.A. (1983). Alteration in Choroid-Plexus Blood Flow and Cerebrospinal- Fluid Formation by Increased Ventricular Pressure. In: Wood, J.H. (eds) Neurobiology of Cerebrospinal Fluid 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9269-3_43
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DOI: https://doi.org/10.1007/978-1-4615-9269-3_43
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