Abstract
The paper by Hamill et al. (1981) has already given an overview of the design of a patch clamp and other apparatus for single-channel recording. This chapter will consider some aspects of the electronic circuitry in greater detail, the main topic being the design of low-noise, wide-bandwidth current-measuring amplifiers. Under good patch-recording conditions, the tight seal (gigaseal) and patch membrane have such a low intrinsic noise level that the movement of a few hundred elementary charges should be detectable. The engineering challenge is to preserve this low noise level in the electronic circuitry.
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© 1983 Plenum Press, New York
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Sigworth, F.J. (1983). Electronic Design of the Patch Clamp. In: Sakmann, B., Neher, E. (eds) Single-Channel Recording. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7858-1_1
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DOI: https://doi.org/10.1007/978-1-4615-7858-1_1
Publisher Name: Springer, Boston, MA
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