Skip to main content
SpringerLink
Log in

Radioprotection in Rat Spinal Cord with WR2721, WR77913 and WR3689 Following Cerebral Lateral Ventricular or Intracisternal Administration

  • Chapter
Anticarcinogenesis and Radiation Protection

  • 112 Accesses

Abstract

The doses of radiotherapy that normal central nervous system (CNS) parenchyma and stroma can tolerate without injury are too low to provide cure for malignant astrocytic gliomas. One potential solution to this problem is to develop compounds that protect the normal CNS tissues more effectively than tumor cells against irradiation. The phosphorothioate radioprotectors such as WR2721, WR77913 and WR3689 are highly water-soluble and do not readily cross the blood-brain barrier. Injection of these drugs via routes that bypass the blood-brain barrier has allowed us to assess radioprotection in the rat cervical spinal cord.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. A.M. Spence, S.W. Edmondson, K.A. Krohn, Z. Grunbaum, J.S. Rasey, and J.E. Steele, Toxicity and biodistribution of the radioprotectors, WR2721, WR77–913, and WR3689 in the CNS following intraventricular or intracisternal administration. Int. J. Radiat. Oncol. Biol. Phys. 12, 1653–1660 (1986).

    Article  PubMed  CAS  Google Scholar 

  2. A.M. Spence, K.A. Krohn, S.W. Edmondson, J.E. Steele, and J.S. Rasey, Radioprotection in rat spinal cord with WR2721 following cerebral lateral intraventricular injection. Int. J. Radiat. Oncol. Biol. Phys.12, 1479–1482 (1986).

    Article  PubMed  CAS  Google Scholar 

  3. A.J. van der Kogel, The cellular basis of radiation-induced damage in the central nervous system. In Cytotoxic Insult to Tissues: Effects on Cell Lineage 1983 (C.S. Potten and J.H. Hendry, Eds.) pp. 329–352, Churchill-Livingstone, Edinburgh.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Divisions of Neurology, Nuclear Medicine and Experimental Biology, University of Washington, 98195, Seattle, Washington, USA

    A. M. Spence, K. A. Krohn, J. E. Steele, S. E. Edmondson & J. S. Rasey

Authors
  1. A. M. Spence
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. A. Krohn
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. E. Steele
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. E. Edmondson
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. S. Rasey
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland

    Peter A. Cerutti

  2. Case Western Reserve University, Cleveland, Ohio, USA

    Oddvar F. Nygaard

  3. National Bureau of Standards, Gaithersburg, Maryland, USA

    Michael G. Simic

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Plenum Press, New York

About this chapter

Cite this chapter

Spence, A.M., Krohn, K.A., Steele, J.E., Edmondson, S.E., Rasey, J.S. (1987). Radioprotection in Rat Spinal Cord with WR2721, WR77913 and WR3689 Following Cerebral Lateral Ventricular or Intracisternal Administration. In: Cerutti, P.A., Nygaard, O.F., Simic, M.G. (eds) Anticarcinogenesis and Radiation Protection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6462-1_60

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-6462-1_60

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-6464-5

  • Online ISBN: 978-1-4615-6462-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation