Abstract
Based on traditional medicinal knowledge, it was possible to identify the plant species Solanum chrysotrichum as the source of a new antimycotic agent designated SC-1. Cell suspension batch cultures from this plant were established in shake flasks, in which the production of SC-1 was optimized, reaching values fifty times higher than those registered in field grown plants. Large-scale cultivation of the active biomass from S, chrysotrichum was established in 10 1 airlift bioreactors, and productivity levels of SC-1 were increased by 60% when using a draw-fill mode in the bioreactors.
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Villarreal, M.L., Nicasio, P., Rojas, G., Alvarez, L., Quintero, R. (1999). Recent Progress in Biotechnology of Mexican Medicinal Plants. In: Shahidi, F., Kolodziejczyk, P., Whitaker, J.R., Munguia, A.L., Fuller, G. (eds) Chemicals via Higher Plant Bioengineering. Advances in Experimental Medicine and Biology, vol 464. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4729-7_17
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DOI: https://doi.org/10.1007/978-1-4615-4729-7_17
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