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Ischemic Brain Damage: Focus On Lipids And Lipid Mediators

  • Chapter
Neurobiology of Essential Fatty Acids

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 318))

Abstract

Two decades ago, Bazan (Bazan, 1970; 1971) demonstrated that ischemia and epileptic seizures are accompanied by lipolysis with accumulation of free fatty acids (FFAs), particularly stearic acid (18:0), arachidonic acid (20:4), and docosahexaenoic acid (22:6). These results were subsequently confirmed and extended by workers interested in ischemia (e.g., DeMedio et al., 1980; Yoshida et al., 1980; 1983; 1986; Rehncrona et al., 1982; Shiu et al., 1983; Abe et al., 1987; Ikeda et al., 1987) or epileptic seizures (Siesjö et al., 1982; Rodriguez de Turco et al., 1983; Reddy and Bazan, 1987). It was also demonstrated that extensive lipolysis with accumulation of FFAs occurs in hypoglycemia (Agardh et al., 1981; Wieloch et al., 1984) and in hypoxia (Gardiner et al., 1981).

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Authors and Affiliations

  1. The Laboratory for Experimental Brain Research Department of Neurobiology, Experimental Research Center University Hospital, S-221 85, Lund, Sweden

    Bo K. Siesjö & Kenichiro Katsura

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  1. Bo K. Siesjö
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  2. Kenichiro Katsura
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Editors and Affiliations

  1. Louisiana State University Eye Center and Neuroscience Center Louisiana State University School of Medicine, New Orleans, Louisiana, USA

    Nicolas G. Bazan

  2. Dalhousie University, Nova Scotia, Canada

    Mary G. Murphy

  3. FIDIA Research Laboratories, Abano Terme, Italy

    Gino Toffano

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Siesjö, B.K., Katsura, K. (1992). Ischemic Brain Damage: Focus On Lipids And Lipid Mediators. In: Bazan, N.G., Murphy, M.G., Toffano, G. (eds) Neurobiology of Essential Fatty Acids. Advances in Experimental Medicine and Biology, vol 318. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3426-6_5

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