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The Discovery of GW Bodies

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Ten Years of Progress in GW/P Body Research

Part of the book series: Advances in Experimental Medicine and Biology ((volume 768))

Abstract

Human autoantibodies were a key to the discovery of GW bodies and their integral protein, GW182. This publication marks the tenth anniversary of the discovery of GW182. As it turns out, the discovery of GW182 was quite timely because it coincided with the elucidation of the RNA interference (RNAi) pathway, which is now known to have a major role in post-transcriptional gene regulation. Following our publication of the essential features of GW182 in 2002, laboratories from around the world began investigations that led to the elucidation of the role of GW182 in RNAi and other pathways of mRNA processing and degradation. This chapter reviews the discovery of GW182 and the description of GWB and some of the observations that followed that still remain to be elucidated.

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Acknowledgments

The authors would like to acknowledge the efforts and expertise of ­numerous colleagues, collaborators, trainees and technologists.

Trainees: Dr. T. Eystathioy, Dr. Z. Yang, Dr. A. Jakymiw, Dr. S. Lian, Dr. S. Li, Dr. J. Moser, Dr. K. Pauley, Dr. L. Luft, Dr. R. Bhanji, K. Griffith, Dr. L. Stinton, Dr. K. Takeuchi.

Collaborators: Drs. D. Zochodne, M. Woods, J. Keene, S. Tenenbaum, B. Séraphin, N. Cougot, N. Kedersha, D. Bloch, L.E.C. Andrade, M. Mahler, M. Satoh, R. Mydlarski, L. Browder.

Technologists: John Hamel, Meifeng Zhang, Haiyan Hou, Maggie Lin, Jane Yang, Carol Peebles.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive N.W., Calgary, AB, Canada, T2N 4N1

    Marvin J. Fritzler

  2. Department of Oral Biology, Health Science Center, University of Florida, 100424, Gainesville, FL, 32610, USA

    Edward K. L. Chan

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Correspondence to Marvin J. Fritzler .

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Editors and Affiliations

  1. College of Dentistry, Department of Oral Biology, University of Florida, Southwest Archer Road 1600, Gainesville, 32610, Florida, USA

    Edward K. L. Chan

  2. Dept. Medicine & Medical Biochemistry, University of Calgary, Hospital Drive NW., 3330, Calgary, T2N 4N1, Alberta, Canada

    Marvin J. Fritzler

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Fritzler, M.J., Chan, E.K.L. (2013). The Discovery of GW Bodies. In: Chan, E., Fritzler, M. (eds) Ten Years of Progress in GW/P Body Research. Advances in Experimental Medicine and Biology, vol 768. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5107-5_2

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