Abstract
According to the often-cited “endorphin hypothesis”, endogenous opioidergic transmitter release has been postulated as the neurochemical basis of some of the psychophysical effects associated with endurance exercise, in particular mood changes. This chapter provides an overview on the applicability of positron emission tomography (PET) ligand activation studies with opioidergic tracers for imaging endogenous opioidergic transmission associated with exercise.
Keywords
- Positron Emission Tomography
- Opioid Receptor
- Positron Emission Tomography Study
- Endurance Exercise
- Positron Emission Tomography Scan
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Boecker H, Sprenger T, Henriksen G, Toelle TR, Spilker ME (2005) Optimal duration of PET studies with 18F-fluoroethyl-diprenorphine. J Nucl Med 46:2092–2096
Boecker H, Henriksen G, Sprenger T, Miederer I, Willoch F, Valet M, Berthele A, Tolle TR (2008a) Positron emission tomography ligand activation studies in the sports sciences: measuring neurochemistry in vivo. Methods 45:307–318
Boecker H, Sprenger T, Spilker ME, Henriksen G, Koppenhoefer M, Wagner KJ, Valet M, Berthele A, Tolle TR (2008b) The runner’s high: opioidergic mechanisms in the human brain. Cereb Cortex 18(11):2523–2531
Boecker H, Othman A, Mueckter S, Scheef L, Pensel M, Daamen M, Jankowski J, Schild HH, Tölle TR, Schreckenberger M (2010) Advocating neuroimaging studies of transmitter release in human physical exercise challenges studies. Open Access J Sports Med 1:167–175
Bruchas MR, Land BB, Chavkin C (2010) The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors. Brain Res 1314:44–55
Carr DB, Bullen BA, Skrinar GS, Arnold MA, Rosenblatt M, Beitins IZ, Martin JB, McArthur JW (1981) Physical conditioning facilitates the exercise-induced secretion of beta-endorphin and beta-lipotropin in women. N Engl J Med 305:560–563
Chaouloff F (1989) Physical exercise and brain monoamines: a review. Acta Physiol Scand 137:1–13
Conroy RW, Smith K, Felthous AR (1982) The value of exercise on a psychiatric hospital unit. Hosp Community Psychiatry 33:641–645
Corbett AD, Henderson G, McKnight AT, Paterson SJ (2006) 75 years of opioid research: the exciting but vain quest for the Holy Grail. Br J Pharmacol 147(Suppl 1):S153–S162
Crozier TA, Kietzmann D, Dobereiner B (2004) Mood change after anaesthesia with remifentanil or alfentanil. Eur J Anaesthesiol 21:20–24
Dalgleish T (2004) The emotional brain. Nat Rev Neurosci 5:583–589
Daniel M, Martin AD, Carter J (1992) Opiate receptor blockade by naltrexone and mood state after acute physical activity. Br J Sports Med 26:111–115
de Oliveira MS, da Silva Fernandes MJ, Scorza FA, Persike DS, Scorza CA, da Ponte JB, de Albuquerque M, Cavalheiro EA, Arida RM (2010) Acute and chronic exercise modulates the expression of MOR opioid receptors in the hippocampal formation of rats. Brain Res Bull 83:278–283
Dearman J, Francis KT (1983) Plasma levels of catecholamines, cortisol, and beta-endorphins in male athletes after running 26.2, 6, and 2 miles. J Sports Med Phys Fitness 23:30–38
Dietrich A, McDaniel WF (2004) Endocannabinoids and exercise. Br J Sports Med 38:536–541
Dishman RK (1985) Medical psychology in exercise and sport. Med Clin North Am 69:123–143
Estorch M, Fuente T, Serra-Grima R, Flotats A, Berna L, Sanz D, Nuno de la Rosa JA, Carrio I (1998) The effect of a race 4 hours in duration on the production of beta-endorphin and adrenocorticotropic hormone. Med Clin (Barc) 111:770–773
Evens N, Muccioli GG, Houbrechts N, Lambert DM, Verbruggen AM, Van Laere K, Bormans GM (2009) Synthesis and biological evaluation of carbon-11- and fluorine-18-labeled 2-oxoquinoline derivatives for type 2 cannabinoid receptor positron emission tomography imaging. Nucl Med Biol 36:455–465
Farrell PA, Gates WK, Maksud MG, Morgan WP (1982) Increases in plasma beta-endorphin/beta-lipotropin immunoreactivity after treadmill running in humans. J Appl Physiol 52:1245–1249
Francis K (1983) The role of endorphins in exercise: a review of current knowledge. J Orthop Sports Phys Ther 4:169–173
Gambert SR, Garthwaite TL, Pontzer CH, Cook EE, Tristani FE, Duthie EH, Martinson DR, Hagen TC, McCarty DJ (1981) Running elevates plasma beta-endorphin immunoreactivity and ACTH in untrained human subjects. Proc Soc Exp Biol Med 168:1–4
Goerendt IK, Messa C, Lawrence AD, Grasby PM, Piccini P, Brooks DJ (2003) Dopamine release during sequential finger movements in health and Parkinson’s disease: a PET study. Brain 126:312–325
Goldfarb AH, Hatfield BD, Armstrong D, Potts J (1990) Plasma beta-endorphin concentration: response to intensity and duration of exercise. Med Sci Sports Exerc 22:241–244
Gunn RN, Gunn SR, Turkheimer FE, Aston JA, Cunningham VJ (2002) Positron emission tomography compartmental models: a basis pursuit strategy for kinetic modeling. J Cereb Blood Flow Metab 22:1425–1439
Harber VJ, Sutton JR (1984) Endorphins and exercise. Sports Med 1:154–171
Hattori S, Naoi M, Nishino H (1994) Striatal dopamine turnover during treadmill running in the rat: relation to the speed of running. Brain Res Bull 35:41–49
Hinton ER, Taylor S (1986) Does placebo response mediate runner’s high? Percept Mot Skills 62:789–790
Janal MN, Colt EW, Clark WC, Glusman M (1984) Pain sensitivity, mood and plasma endocrine levels in man following long-distance running: effects of naloxone. Pain 19:13–25
Jarvekulg A, Viru A (2002) Opioid receptor blockade eliminates mood effects of aerobic gymnastics. Int J Sports Med 23:155–157
Knechtle B (2004) Influence of physical activity on mental well-being and psychiatric disorders. Praxis (Bern 1994) 93:1403–1411
Koepp MJ, Gunn RN, Lawrence AD, Cunningham VJ, Dagher A, Jones T, Brooks DJ, Bench CJ, Grasby PM (1998) Evidence for striatal dopamine release during a video game. Nature 393:266–268
Kringelbach ML, Berridge KC (2010) The functional neuroanatomy of pleasure and happiness. Discov Med 9:579–587
Laruelle M (2000) Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review. J Cereb Blood Flow Metab 20:423–451
Lasagna L, Von Felsinger JM, Beecher HK (1955) Drug-induced mood changes in man. I. Observations on healthy subjects, chronically ill patients, and postaddicts. J Am Med Assoc 157:1006–1020
Markoff RA, Ryan P, Young T (1982) Endorphins and mood changes in long-distance running. Med Sci Sports Exerc 14:11–15
Meeusen R, Smolders I, Sarre S, de Meirleir K, Keizer H, Serneels M, Ebinger G, Michotte Y (1997) Endurance training effects on neurotransmitter release in rat striatum: an in vivo microdialysis study. Acta Physiol Scand 159:335–341
Melichar JK, Nutt DJ, Malizia AL (2003) Naloxone displacement at opioid receptor sites measured in vivo in the human brain. Eur J Pharmacol 459:217–219
Morgan WP (1985) Affective beneficence of vigorous physical activity. Med Sci Sports Exerc 17:94–100
Mougin C, Baulay A, Henriet MT, Haton D, Jacquier MC, Turnill D, Berthelay S, Gaillard RC (1987) Assessment of plasma opioid peptides, beta-endorphin and met-enkephalin, at the end of an international nordic ski race. Eur J Appl Physiol Occup Physiol 56:281–286
Partin C (1983) Runner’s “high”. JAMA 249:21
Petraglia F, Bacchi Modena A, Comitini G, Scazzina D, Facchinetti F, Fiaschetti D, Genazzani AD, Barletta C, Scavo D, Genazzani AR (1990) Plasma beta-endorphin and beta-lipotropin levels increase in well trained athletes after competition and non competitive exercise. J Endocrinol Invest 13:19–23
Pfeiffer A, Brantl V, Herz A, Emrich HM (1986) Psychotomimesis mediated by kappa opiate receptors. Science 233:774–776
Pierce EF, McGowan RW, Lynn TD (1993) Exercise dependence in relation to competitive orientation of runners. J Sports Med Phys Fitness 33:189–193
Radosevich PM, Nash JA, Lacy DB, O’Donovan C, Williams PE, Abumrad NN (1989) Effects of low- and high-intensity exercise on plasma and cerebrospinal fluid levels of ir-beta-endorphin, ACTH, cortisol, norepinephrine and glucose in the conscious dog. Brain Res 498:89–98
Rosch PJ (1985) Exercise and stress reduction. Compr Ther 11:10–15
Sforzo GA (1989) Opioids and exercise. An update. Sports Med 7:109–124
Sforzo GA, Seeger TF, Pert CB, Pert A, Dotson CO (1986) In vivo opioid receptor occupation in the rat brain following exercise. Med Sci Sports Exerc 18:380–384
Sher L (1996) Exercise, wellbeing, and endogenous molecules of mood. Lancet 348:477
Sparling PB, Giuffrida A, Piomelli D, Rosskopf L, Dietrich A (2003) Exercise activates the endocannabinoid system. Neuroreport 14:2209–2211
Spilker ME, Sprenger T, Valet M, Henriksen G, Wagner K, Wester HJ, Toelle TR, Boecker H (2004) Quantification of [18F]diprenorphine kinetics in the human brain with compartmental and non-compartmental modeling approaches. Neuroimage 22:1523–1533
Terry G, Liow JS, Chernet E, Zoghbi SS, Phebus L, Felder CC, Tauscher J, Schaus JM, Pike VW, Halldin C, Innis RB (2008) Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents. Neuroimage 41:690–698
Van Laere K, Koole M, Sanabria Bohorquez SM, Goffin K, Guenther I, Belanger MJ, Cote J, Rothenberg P, De Lepeleire I, Grachev ID, Hargreaves RJ, Bormans G, Burns HD (2008) Whole-body biodistribution and radiation dosimetry of the human cannabinoid type-1 receptor ligand 18F-MK-9470 in healthy subjects. J Nucl Med 49:439–445
Wagemaker H, Goldstein L (1980) The runner’s high. J Sports Med Phys Fitness 20:227–229
Wagner KJ, Valet M, Kochs EF, Kriner M, Tolle TR, Sprenger T (2010) The mu-opioid receptor agonist remifentanil induces acute dysphoria irrespective of its analgesic properties. J Psychopharmacol 24:355–361
Wang GJ, Volkow ND, Fowler JS, Franceschi D, Logan J, Pappas NR, Wong CT, Netusil N (2000) PET studies of the effects of aerobic exercise on human striatal dopamine release. J Nucl Med 41:1352–1356
Wester HJ, Willoch F, Tolle TR, Munz F, Herz M, Oye I, Schadrack J, Schwaiger M, Bartenstein P (2000) 6-O-(2-[18F]fluoroethyl)-6-O-desmethyldiprenorphine ([18F]DPN): synthesis, biologic evaluation, and comparison with [11C]DPN in humans. J Nucl Med 41:1279–1286
Wildmann J, Kruger A, Schmole M, Niemann J, Matthaei H (1986) Increase of circulating beta-endorphin-like immunoreactivity correlates with the change in feeling of pleasantness after running. Life Sci 38:997–1003
Wilson WM, Marsden CA (1995) Extracellular dopamine in the nucleus accumbens of the rat during treadmill running. Acta Physiol Scand 155:465–466
Zubieta JK, Stohler CS (2009) Neurobiological mechanisms of placebo responses. Ann N Y Acad Sci 1156:198–210
Zubieta JK, Smith YR, Bueller JA, Xu Y, Kilbourn MR, Jewett DM, Meyer CR, Koeppe RA, Stohler CS (2001) Regional mu opioid receptor regulation of sensory and affective dimensions of pain. Science 293:311–315
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Boecker, H., Tölle, T.R., Valet, M., Sprenger, T. (2012). Effects of Aerobic Exercise on Mood and Human Opioidergic Activation Measured by Positron Emission Tomography. In: Boecker, H., Hillman, C., Scheef, L., Strüder, H. (eds) Functional Neuroimaging in Exercise and Sport Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3293-7_22
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