Abstract
Dramatic advances have been made in recent years in the identification and isolations of hormonal receptors (Sica et al., 1976) and of the nicotinic cholinergic receptors of invertebrates (Changeux, 1975). Patrick and Lindstrom (1973) have administered a solubilized and purified form of the nicotinic cholinergic receptor from the electric organ of the eel or fish into animals and have produced a flaccid paralysis which electromyographically and pharmacologically exhibits similar symptoms to myasthenia gravis. Tremendous gains have been made towards understanding the autoimmune aspects of this debilitating disease (Elias and Appel, 1976, Lindstrom et al., 1976).
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References
Aquilonius, S.M., and Eckernas, S.A., 1977, Choline therapy in Huntington’s chorea, Neurology 27: 887.
Aquilonius, S.M., Eckernas, S.A., and Sundwall, A., 1975, Regional distribution of choline acetyltransferase in the human brain: changes in Huntington’s chorea, J. Neurol. Neurosurg. Psychiatry 38: 669.
Aquilonius, S.M., and Sjostrom, R., 1971, Cholinergic and dopaminergic mechanisms in Huntington’s chorea, Life Sci. 10: 405.
Barbeau,A., Biochemistry of Huntington’s chorea, in “Advances in Neurology, Vol. 1, Huntington’s chorea 1872–1972”(A. Barbeau, T.N. Chase, and G.W. Paulson, eds.), pp. 473–516, Raven Press, New York.
Bartfai, T. (personal communication).
Bird, E.D., and Iversen, L.L., 1974, Huntington’s chorea: postmortem measurement of glutamic acid decarboxylase, choline acetyltransferase and dopamine in basal ganglia, Brain 97: 457.
Bird, E.D., and Iversen, L.L., 1976, Neurochemical findings in Huntington’s chorea, in “Essays in Neurochemistry” ( M. Youdim, D. Sharman, W. Lovenberg, and J. Ragnodo, eds.), pp. 177–195, Wiley and Son, New York.
Burt, D.B., Creese,. I., and Snyder, S.H., 1976, Properties of 3H-haloperidol and 3H- dopamine binding associated with dopamine receptors in calf brain membrances, Mol. Pharmacol. 12: 631.
Changeux, J.P., 1975, The cholinergic receptor protein from fish electric organ, in “Handbook of Psychopharmacology” (S. Iversen, L. Iversen, and S. Snyder, eds.), pp. 235–293, Plenum Press, New York.
Chase, T.N., 1973, Biochemical and pharmacologic studies of monoamines in Huntington’s chorea, in “Advances in Neurology, Vol. 1, Huntington’s Chorea 1872–1972” ( A. Barbeau, T.N. Chase, and G.W. Paulson, eds.), pp. 533–542, Raven Press, New York.
Coyle, J.T., and Schwarcz, R., 1976, Lesion of striatal neurones with kainic acid provides a model for Huntington’s chorea, Nature 263: 244.
Coyle, J.T., Schwarcz, R., Bennett, J.P., and Campochiaro, P., 1977, Clinical, neuropathology and pharmacologic aspects of Huntington’s disease: correlates with a new animal model, Neuropsychopharmacology 1: 1.
Cuatrecasas, P., and Hollenberg, M., 1976, Membrane receptors and hormone action, Adv. Protein Chem. 30: 251.
Davis, K.L., Hollister, L.E., Berger, P.A., and Barchas, J.D., 1975, Cholinergic imbalance hypotheses of psychoses and movement disorders: strategies for evaluation, Psychopharmacol. Comm. 1(5): 533.
Davis, K.L., Hollister, L.E., Barchas, J.D., and Berger, P.A., 1976, Choline in tardive dyskinesia and Huntington’s chorea, Life Sci. 19: 1507.
Dill, R.E., Dorris, R.L., and Phillips-Thonnard, I., 1976, A pharmacologic model of Huntington’s chorea, J. Pharm. Pharmacol. 28: 646.
Elias, S.B., and Appel, S.H., 1976, Recent advances in myasthenia gravis, Life Sci. 18: 1031.
Enna, S.J., Bennett, J.P., Bylund, D.B., Snyder, S.H., Bird, E.D., and Iversen, L.L., 1976, Alterations of brain neurotransmitter receptor binding in Huntington’s chorea, Brain Res. 116: 531.
Enna, S.J., Bird, E.D., Bennett, J.P., Bylund, D.B., Yamamura, H.I., Iversen, L.L., and Snyder, S.H., 1976, Huntington’s chorea: changes in neurotransmitter receptors in the brain, TV. Engl. J. Med. 294: 1305.
Enna, S.J., Stern, L.Z., Wastek, G.J., and Yamamura, H.I., 1977, Neurobiology and pharmacology of Huntington’s disease, Life Sci. 20: 205.
Ferrendelli, J.A., Steiner, A.L., McDough, D.B., and Kipnis, D.M., 1970, The effect of oxotremorine and atropine on cGMP and cAMP levels in mouse cerebral cortex and cerebellum, Biochem. Biophys. Res. Commun. 41: 1061.
Growdon, J.H., Cohen, E.L., and Wurtman, R.J., 1977, Huntington’s disease: clinical and chemical effects of choline administration, Ann. Neurol. 7: 418.
Hiley, C.R., 1976, The muscarinic receptor for acetylcholine in Huntington’s chorea, in “Biochemistry and Neurology” ( H. Bradford, and C. Marsden, eds.), pp. 103–109, Academic Press, New York.
Hiley, C.R., and Bird, E.D., 1974, Decreased muscarinic receptor concentration in postmortem brain in Huntington’s chorea, Brain Res. 80: 355.
Iversen, L.L., 1975, Dopamine receptors in the brain, Science 188: 1084.
Klawans, H.L., and Rubovits, R., 1973, Central cholinergic-anticholinergic antagonism in Huntington’s chorea, Neurology 22: 107.
Kuo, J.F., Lee, T.P., Reyes, P.L., Walton, K.G., Donnalley, T.E., and Greengard, P., 1972, Cyclic nucleotide-dependent protein kinases X. An assay method for the measurement of guanosine 3, 5-monophosphate in various biological materials and a study of agents regulating its level in heart and brain, J. Biol. Chem. 247: 16.
Laterre, E.C., and Fortemps, E., 1975, Deanol in spontaneous and induced dyskinesias, Lancet 1 (7919): 1301.
Lee, T.P., Kuo, J.F., and Greengard, P., 1972, Role of muscarinic cholinergic receptors in regulation of guanosine 3, 5-cyclic monophosphate content in mammalian brain, heart muscle, and intestinal smooth muscle, Proc. Natl. Acad. Sci. USA 69: 3287.
Lindstrom, J.M., Seybold, M.E., Lennon, V.A., Whittingham, S., and Duane, D.P., 1976, Antibody to acetylcholine receptor in myasthenia gravis, Neurology 26: 1054.
McGeer, P.L., and McGeer, E.G., 1976, Enzymes associated with the metabolism of catecholamines, acetylcholine and GABA in human controls and patients with Parkinson’s disease and Huntington’s chorea, J. Neurochem. 26:65.
Patrick, J., and Lindstrom, J., 1973, Autoimmune response to acetylcholine receptor, Science 18: 871.
Phillis, J.W., 1970, Pharmacological studies on neurons in the brain and spinal cord. — Part 1: Cholinergic mechanisms, in “The Pharmacology of Synapses” (G.A. Kerkut, ed.), pp. 149 - 185, Oxford Pergamon Press, New York.
Reisine, T.D., Fields, J.Z., Stern, L.Z., Johnson, P.C., Bird, E.D., and Yamamura, H.I., in press, Alterations in dopaminergic receptors in Huntington’s disease, Life Sci.
Richelson, E., 1977, Antipsychotics block muscarinic acetylcholine receptor-mediated cyclic GMP formation in cultured mouse neuroblastoma cells, Nature 266: 311.
Shoulson, I., and Chase, T.N., 1975, Huntington’s disease, Ann. Rev. Med. 26: 419.
Sica, V., Cuatrecasas, P., Nola, E., Parikh, I., and Puca, G.A., 1976, Purification of estrogen receptor by affinity chromatography, in “Receptors and Mechanisms of Action of Steroid Hormones” (J. Pasqualini, ed.), pp. 85–107, M. Dekker, New York.
Snyder, S.H., and Bennett, J.P., 1976, Neurotransmitter receptors in the brain: biochemical identification, Ann. Rev. Physiol. 38: 153.
Strange, P.G., Birdsall, N.J.M., and Burgen, A.S.V., 1977, Occupancy of muscarinic acetylcholine receptors stimulates a guanytale cyclase in neuroblastoma cells, Biochem. Soc. Trans. 5: 189.
Tarsy, D., Leopold, N., and Sax, D.S., 1974, Physostigmine in choreiform movement disorders, Neurology 24: 28.
Urquhart, N., Perry, T.L., Hansen, S., and Kennedy, J., 1975, GABA content and glutamic acid decarboxylase activity in brain of Huntington’s chorea patients and control subjects, J. Neurochem. 24: 1071.
Walker, J.E., Hoehn, M., Sears, E., and Lewis, J., 1973, Dimethylaminoethanol in Huntington’s chorea, Lancet 1(7818): 1512.
Wastek, G.J., Stern, L.Z., Johnson, P.C., and Yamamura, H.I., 1976, Huntington’s disease: regional alterations in muscarinic cholinergic receptor binding in human brain, Life Sci. 19: 1033.
Yamamura, H.I., Kuhar, M.J., Greenberg, D., and Snyder, S.H., 1974, Muscarinic cholinergic binding: regional distribution in monkey brain, Brain Res. 66: 541.
Yamamura, H.I., and Snyder, S.H., 1974a, Muscarinic cholinergic binding in rat brain, Proc. Natl Acad. Sei. USA 77: 1725.
Yamamura, H.I., and Snyder, S.H., 1974b, Muscarinic cholinergic receptor binding in the longitudinal muscle of the guinea pig ileum with 3H-quinuclidinyl benzilate, Mol. Pharmacol. 10: 861.
Young, A.B., and Snyder, S.H., 1973, Strychnine binding associated with glycine receptors of the central nervous system, Proc. Natl. Acad. Sei. USA 70: 2832.
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Yamamura, H.I., Wastek, G.J., Hruska, R.E. (1979). Alterations in Muscarinic Cholinergic Receptor Binding in Huntington’s Disease. In: Davis, K.L., Berger, P.A. (eds) Brain Acetylcholine and Neuropsychiatric Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2934-3_12
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DOI: https://doi.org/10.1007/978-1-4613-2934-3_12
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