Abstract
Radionuclide imaging has become an important method in the detection and staging of neoplastic diseases. However, most nuclear imaging methods localize lesions by indirectly demonstrating a decrease in the accretion of the radiopharmaceutical (negative image) or by a physiologic attribute of the tissue that permits a positive image of the lesion. For example, to the extent that a tumor lacks organ-specific properties, an organ-imaging agent could be used to show the tumor as a defect, such as with technetium sulfur colloid for imaging the liver and spleen. The development of more selective methods for localizing tumors by means of anti-cancer antibodies labeled with a radionuclide suitable for external imaging has been a recent approach gaining in interest and application for cancer imaging, although it has been pursued for over 30 years [1–3]. Early animal studies in the 1950s showed that radio-iodinated antibodies prepared against extracts of rodent tumors could localize in these tumors selectively [1,4,5]. Subsequently, it was found that this preferential tumor accretion of the radioactive antibodies was due mainly to anti-fibrin antibodies [1,6–8]; anti-fibrinogen antibodies were later explored for tumor imaging and therapy [1,9].
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Goldenberg, D.M. et al. (1990). In-vivo antibody imaging for the detection of human tumors. In: Goldenberg, D.M. (eds) Cancer Imaging with Radiolabeled Antibodies. Cancer Treatment and Research, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1497-4_14
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