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FOXO1, T-Cell Trafficking and Immune Responses

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Book cover Forkhead Transcription Factors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 665))

Abstract

Efficient T-cell adaptive immune response require a faultless coordination between migration of naive T-cells into secondary lymphoid organs and critical biological outcomes driven by antigen such as cell division and cell differentiation into effector and memory cells. Recent works have shown that the phosphoinositide 3-kinase (PI3K) pathway could govern several of these processes. In this control, transcriptional factors of the Forkhead box O (FoxO) family, in particular FOXO1, a downstream effector ofPI3K, appears to play a major role by coordinating both cellular proliferation of T-cells after antigen recognition and expression of homing molecules essential for their trafficking in the body.

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Authors and Affiliations

  1. Centre National de la Recherche Scientifique Equipe labellisée par la Ligue Nationale contre le Cancer, Institut Cochin Université Paris Descartes, 22 rue Méchaln, 75014, Paris, France

    Florent Carrette, Stéphanie Fabre & Georges Bismuth

  2. Unité 567, Institut National de la Santé et de la Recherche Médicale, Paris, France

    Florent Carrette, Stéphanie Fabre & Georges Bismuth

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  1. Florent Carrette
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  2. Stéphanie Fabre
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  3. Georges Bismuth
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Correspondence to Georges Bismuth .

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Editors and Affiliations

  1. Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  2. Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  3. Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  4. Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  5. Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  6. Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

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Carrette, F., Fabre, S., Bismuth, G. (2009). FOXO1, T-Cell Trafficking and Immune Responses. In: Maiese, K. (eds) Forkhead Transcription Factors. Advances in Experimental Medicine and Biology, vol 665. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1599-3_1

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