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The Sarcomere and Sarcomerogenesis

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The Sarcomere and Skeletal Muscle Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 642))

Abstract

Striated muscle owes its name to the microscopic appearance, caused by the longitudinal alignment of thousands of highly ordered contractile units, the sarcomeres. The assembly (and disassembly) of these multiprotein complexes (sarcomere assembly or sarcomerogenesis) follows ordered pathways, which are regulated on the transcriptional, translational and posttranslational level. Furthermore, myofibril assembly involves the participation of transient scaffolds and adaptors, notably the microtubule network. Studies in cell culture and developing embryos have revealed common pathways of sarcomere assembly in heart and skeletal muscle. Disruptions in these pathways are implicated in muscle diseases.

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  1. Cardiovascular Division and Randall Division for Cell and Molecular Biophysics, King’s College London, London, SE1 1UL, UK

    Elisabeth Ehler & Mathias Gautel

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  1. Elisabeth Ehler
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  2. Mathias Gautel
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Correspondence to Elisabeth Ehler .

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  1. Centre for Medical Research, University of Western Australia, Western Australian Institute for Medical Research, Nedlands, Western Australia, Australia

    Nigel G. Laing PhD

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Ehler, E., Gautel, M. (2008). The Sarcomere and Sarcomerogenesis. In: Laing, N.G. (eds) The Sarcomere and Skeletal Muscle Disease. Advances in Experimental Medicine and Biology, vol 642. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84847-1_1

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