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Endocannabinoid Functions in Neurogenesis, Neuronal Migration, and Specification

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Endocannabinoids act as retrograde messengers thus controlling many synapses in the postnatal brain. In contrast, the concept that endocannabinoid functions are pivotal to fundamental developmental processes, including progenitor proliferation and fate specification, lineage segregation, neuronal migration, differentiation and survival, in the embryonic brain has just begun to emerge. Understanding the basic developmental and signaling principles controlled by endocannabinoids is pertinent to defining the molecular mechanisms establishing functional neuronal circuits with particular emphasis on synapse specification and functional diversification. Deciphering the spatial and temporal context of endocannabinoid signaling will also reveal the molecular substrates of permanent modifications to cellular structure and functions imposed by in utero cannabis exposure. Here, we review the ontogeny and recently identified functions of the endocannabinoid system with emphasis on the neuronal lineage during brain development, and discuss how fetal cannabis exposure may modify neuronal networks such that longterm changes to cognitive functions manifest in the affected offspring.

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Authors and Affiliations

  1. Institute of Medical Sciences, University of Aberdeen, Foresterhill AB25 2ZD, Aberdeen, Scotland, UK

    Tibor Harkany

  2. Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040, Madrid, Spain

    Manuel Guzmán

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  1. Center for Neurosciences of Coimbra, University of Coimbra, Coimbra, 3000-045, Portugal

    Attila Köfalvi (Faculty of Medicine) (Faculty of Medicine)

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Harkany, T., Guzmán, M., Hurd, Y.L. (2008). Endocannabinoid Functions in Neurogenesis, Neuronal Migration, and Specification. In: Köfalvi, A. (eds) Cannabinoids and the Brain. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-74349-3_12

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