Castleman’s disease (CD) was first described in 1954 and further defined in 1956 by Dr. Castleman (1) (Figure 13.1). He reported on patients possessing localized mediastinal lymph node enlargement that was characterized by redundancy of lymphoid follicles with germinal-center involution as well as marked capillary proliferation with endothelial hyperplasia in both follicular and interfollicular regions. Prior cases had been reported, but were anecdotal in nature (2, 3). In 1962, Lattes and Pachter evaluated 12 cases and suggested that these lymph nodes were hamartomatous in nature (4). Lee described refractory anemia associated with CD that responded to surgical resection 5, and by 1967, Tung and McCormack described 5 new cases and reviewed the 62 cases described to that point in the literature (6), highlighting the potential for associated hypochromic anemia, hypergammaglobulinemia, and bone marrow plasmacytosis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Dispenzieri, A. (2008). Castleman Disease. In: Ansell, S.M. (eds) Rare Hematological Malignancies., vol 142. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-73744-7_13
Download citation
DOI: https://doi.org/10.1007/978-0-387-73744-7_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-73743-0
Online ISBN: 978-0-387-73744-7
eBook Packages: MedicineMedicine (R0)