Abstract
The motivation to seek out and consume rewards has evolutionarily been driven by the urge to fulfill physiological needs. However in a modern society dominated more by plenty than scarcity, we tend to think of motivation as fueled by the search for pleasure. Here, we argue that two separate but interconnected subcortical and unconscious processes direct motivation: “wanting” and “liking.” These two psychological and neuronal processes and their related brain structures typically work together, but can become dissociated, particularly in cases of addiction. In drug addiction, for example, repeated consumption of addictive drugs sensitizes the mesolimbic dopamine system, the primary component of the “wanting” system, resulting in excessive “wanting” for drugs and their cues. This sensitizing process is long-lasting and occurs independently of the “liking” system, which typically remains unchanged or may develop a blunted pleasure response to the drug. The result is excessive drug-taking despite minimal pleasure and intense cue-triggered craving that may promote relapse long after detoxification. Here, we describe the roles of “liking” and “wanting” in general motivation and review recent evidence for a dissociation of “liking” and “wanting” in drug addiction, known as the incentive sensitization theory (Robinson and Berridge 1993). We also make the case that sensitization of the “wanting” system and the resulting dissociation of “liking” and “wanting” occurs in both gambling disorder and food addiction.
Keywords
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American Psychiatric Association (2013) American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5®). American Psychiatric Association, Arlington
Anselme P (2013) Dopamine, motivation, and the evolutionary significance of gambling-like behaviour. Behav Brain Res 256C:1–4. doi:10.1016/j.bbr.2013.07.039
Anselme P, Robinson MJF, Berridge KC (2013) Reward uncertainty enhances incentive salience attribution as sign-tracking. Behav Brain Res 238:53–61. doi:10.1016/j.bbr.2012.10.006
Avena NM, Hoebel BG (2003a) A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine. Neuroscience 122:17–20
Avena NM, Hoebel BG (2003b) Amphetamine-sensitized rats show sugar-induced hyperactivity (cross-sensitization) and sugar hyperphagia. Pharmacol Biochem Behav 74:635–639
Avena NM, Rada P, Hoebel BG (2008) Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev 32:20–39. doi:10.1016/j.neubiorev.2007.04.019
Balfour DJK, Munafò MR (2015) The role of mesoaccumbens dopamine in nicotine dependence. 24:1–172. doi:10.1007/978-3-319-13482-6_3
Balodis IM, Kober H, Worhunsky PD et al (2012) Diminished frontostriatal activity during processing of monetary rewards and losses in pathological gambling. Biol Psychiatry 71:749–757. doi:10.1016/j.biopsych.2012.01.006
Barrett SP, Pihl RO, Benkelfat C et al (2008) The role of dopamine in alcohol self-administration in humans: individual differences. Europ Neuropsychopharmacol 18:439–447. doi:10.1016/j.euroneuro.2008.01.008
Bechara A, Martin GM, Pridgar A, van der Kooy D (1993) The parabrachial nucleus: a brain stem substrate critical for mediating the aversive motivational effects of morphine. Behav Neurosci 107:147–160
Benowitz NL (1996) Pharmacology of nicotine: addiction and therapeutics. Annu Rev Pharmacol Toxicol 36:597–613. doi:10.1146/annurev.pa.36.040196.003121
Berger SP, Hall S, Mickalian JD et al (1996) Haloperidol antagonism of cue-elicited cocaine craving. Lancet 347:504–508
Bernard LC, Mills M, Swenson L, Walsh RP (2005) An Evolutionary Theory of Human Motivation. Genet Soc Gen Psychol Monogr 131:129–184. doi:10.3200/MONO.131.2.129-184
Berridge KC (2003) Pleasures of the brain. Brain Cognit
Berridge KC, Ho C-Y, Richard JM, DiFeliceantonio AG (2010) The tempted brain eats: pleasure and desire circuits in obesity and eating disorders. Brain Res 1350:43–64. doi:10.1016/j.brainres.2010.04.003
Berridge KC, Kringelbach ML (2008) Affective neuroscience of pleasure: reward in humans and animals. Psychopharmacology 199:457–480. doi:10.1007/s00213-008-1099-6
Berridge KC, Robinson TE (2003) Parsing reward. Trends Neurosci 26:507–513
Berridge KC, Robinson TE (1998) What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Rev 28:309–369
Berridge KC, Robinson TE (2011) Drug Addiction as Incentive Sensitization. In: Poland J, Graham G (eds) Addict & Responsibility. MIT Press, Cambridge, pp 21–54
Berridge KC, Robinson TE, Aldridge JW (2009) Dissecting components of reward: ‘liking’, “wanting”, and learning. Curr Opin Pharmacol 9:65–73. doi:10.1016/j.coph.2008.12.014
Berridge KC, Valenstein ES (1991) What psychological process mediates feeding evoked by electrical stimulation of the lateral hypothalamus? Behav Neurosci 105:3–14
Bindra D (1978) How adaptive behavior is produced: a perceptual- motivational alternative to response-reinforcement. Behav Brain Sci 1:41–91
Boakes RA, Poli M, Lockwood MJ, Goodall G (1978) A study of misbehavior: token reinforcement in the rat. J Exp Anal Behav 29:115–134
Boileau I, Dagher A, Leyton M et al (2006) Modeling sensitization to stimulants in humans: an [11C]raclopride/positron emission tomography study in healthy men. Arch Gen Psychiatry 63:1386–1395. doi:10.1001/archpsyc.63.12.1386
Boileau I, Payer D, Chugani B, et al (2013) In vivo evidence for greater amphetamine-induced dopamine release in pathological gambling: a positron emission tomography study with [11C]-(+)-PHNO. Mol Psychiatry 19:1305–1313. doi:10.1038/mp.2013.163
Brauer LH, De Wit H (1997) High dose pimozide does not block amphetamine-induced euphoria in normal volunteers. Pharmacol Biochem Behav 56:265–272
Brevers D, Bechara A, Hermoye L et al (2014a) Comfort for uncertainty in pathological gamblers: a fMRI study. Behav Brain Res 278C:262–270. doi:10.1016/j.bbr.2014.09.026
Brevers D, Koritzky G, Bechara A, Noël X (2014b) Cognitive processes underlying impaired decision-making under uncertainty in gambling disorder. Addict Behav 39:1533–1536. doi:10.1016/j.addbeh.2014.06.004
Brown PL, Jenkins HM (1968) Auto-shaping of the pigeon’s key-peck. J Exp Anal Behav 11:1–8. doi:10.1901/jeab.1968.11-1
Burger KS, Stice E (2014) Greater striatopallidal adaptive coding during cue–reward learning and food reward habituation predict future weight gain. Neuroimage 99:122–128. doi:10.1016/j.neuroimage.2014.05.066
Cabanac M (1971) Physiological role of pleasure. Science 173:1103–1107
Cadet JL, Bisagno V, Milroy CM (2014) Neuropathology of substance use disorders. Acta Neuropathol 127:91–107. doi:10.1007/s00401-013-1221-7
Caggiula AR, Donny EC, Palmatier MI et al (2009) The role of nicotine in smoking: a dual-reinforcement model. Nebr Symp Motiv 55:91–109
Cannon CM, Palmiter RD (2003) Reward without dopamine. J Neurosci 23:10827–10831
Cardinal RN, Howes NJ (2005) Effects of lesions of the nucleus accumbens core on choice between small certain rewards and large uncertain rewards in rats. BMC Neurosci 6:37. doi:10.1186/1471-2202-6-37
Cardinal RN, Parkinson JA, Hall J, Everitt BJ (2002) Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci Biobehav Rev 26:321–352
Casey KF, Benkelfat C, Young SN, Leyton M (2006) Lack of effect of acute dopamine precursor depletion in nicotine-dependent smokers. Europ Neuropsychopharmacol 16:512–520. doi:10.1016/j.euroneuro.2006.02.002
Castellanos EH, Charboneau E, Dietrich MS et al (2009) Obese adults have visual attention bias for food cue images: evidence for altered reward system function. Int J Obes (Lond) 33:1063–1073. doi:10.1038/ijo.2009.138
Castner SA, Goldman-Rakic PS (1999) Long-lasting psychotomimetic consequences of repeated low-dose amphetamine exposure in rhesus monkeys. Neuropsychopharmacol 20:10–28. doi:10.1016/S0893-133X(98)00050-5
Castro DC, Berridge KC (2014) Opioid Hedonic Hotspot in Nucleus Accumbens Shell: Mu, Delta, and Kappa Maps for Enhancement of Sweetness “Liking” and “Wanting”. J Neurosci 34:4239–4250. doi:10.1523/JNEUROSCI.4458-13.2014
Castro DC, Cole SL, Berridge KC (2015) Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry. Front Syst Neurosci 9:1–17. doi:10.3389/fnsys.2015.00090
Childress AR, Ehrman RN, Wang Z et al (2008) Prelude to passion: limbic activation by “unseen” drug and sexual cues. PLoS ONE 3:e1506. doi:10.1371/journal.pone.0001506
Clark L, Lawrence AJ, Astley-Jones F, Gray N (2009) Gambling near-misses enhance motivation to gamble and recruit win-related brain circuitry. Neuron 61:481–490. doi:10.1016/j.neuron.2008.12.031
Cochin J, Kornetsky C (1964) Development and loss of tolerance to morphine in the rat after single and multiple injections. J Pharmacol Exp Ther 145:1–10
Costikyan G (2013) Uncertainty in Games. MIT Press, Cambridge
Cota D, Barrera JG, Seeley RJ (2006) Leptin in energy balance and reward: two faces of the same coin? Neuron 51:678–680. doi:10.1016/j.neuron.2006.09.009
Cruz FC, Marin MT, Leão RM, Planeta CS (2011) Stress-induced cross-sensitization to amphetamine is related to changes in the dopaminergic system. J Neural Transm 119:415–424. doi:10.1007/s00702-011-0720-8
Cunningham ST, Kelley AE (1992) Evidence for opiate-dopamine cross-sensitization in nucleus accumbens: studies of conditioned reward. Brain Res Bull 29:675–680
Dai X, Brendl CM, Ariely D (2010) Wanting, liking, and preference construction. Emotion 10:324–334. doi:10.1037/a0017987
Davis C, Carter JC (2009) Compulsive overeating as an addiction disorder. A review of theory and evidence. Appetite 53:1–8. doi:10.1016/j.appet.2009.05.018
Davis CA, Levitan RD, Reid C et al (2009) Dopamine for “wanting” and opioids for “liking”: a comparison of obese adults with and without binge eating. Obesity 17:1220–1225. doi:10.1038/oby.2009.52
Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85:5274–5278
DiFeliceantonio AG, Berridge KC (2012) Which cue to “want?” Opioid stimulation of central amygdala makes goal-trackers show stronger goal-tracking, just as sign-trackers show stronger sign-tracking. Behav Brain Res 230:399–408. doi:10.1016/j.bbr.2012.02.032
DiFeliceantonio AG, Mabrouk OS, Kennedy RT, Berridge KC (2012) Enkephalin surges in dorsal neostriatum as a signal to eat. Curr Biol 22:1918–1924. doi:10.1016/j.cub.2012.08.014
Dow Schüll N (2012) Addiction by Design: Machine Gambling in Las Vegas, 1st edn. Princeton University Press, Princeton
Elliott SS, Keim NL, Stern JS et al (2002) Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 76:911–922
Evans AH, Pavese N, Lawrence AD et al (2006) Compulsive drug use linked to sensitized ventral striatal dopamine transmission. Ann Neurol 59:852–858. doi:10.1002/ana.20822
Everitt BJ, Belin D, Economidou D et al (2008) Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos Trans R Soc, Biol Sci 363:3125–3135
Farooqi IS, Bullmore ET, Keogh J et al (2007) Leptin regulates striatal regions and human eating behavior. Science 317:1355. doi:10.1126/science.1144599
Farooqi IS, O’Rahilly S (2009) Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr 89:980S–984S. doi:10.3945/ajcn.2008.26788C
Ferrario CR, Gorny G, Crombag HS et al (2005) Neural and behavioral plasticity associated with the transition from controlled to escalated cocaine use. Biol Psychiatry 58:751–759. doi:10.1016/j.biopsych.2005.04.046
Ferrario CR, Robinson TE (2007) Amphetamine pretreatment accelerates the subsequent escalation of cocaine self-administration behavior. Eur Neuropsychopharmacol 17:352–357. doi:10.1016/j.euroneuro.2006.08.005
Fiorillo CD (2011) Transient activation of midbrain dopamine neurons by reward risk. Neuroscience 197:162–171. doi:10.1016/j.neuroscience.2011.09.037
Fiorillo CD, Tobler PN, Schultz W (2003) Discrete coding of reward probability and uncertainty by dopamine neurons. Science 299:1898–1902. doi:10.1126/science.1077349
Fischman MW, Foltin RW (1992) Self-administration of cocaine by humans: a laboratory perspective. Ciba Found Symp 166:165–180
Garcia J, Lasiter PS, Bermudez-Rattoni F, Deems DA (1985) A general theory of aversion learning. Ann N Y Acad Sci 443:8–21
Garcia-Keller C, Martinez SA, Esparza MA et al (2013) Cross-sensitization between cocaine and acute restraint stress is associated with sensitized dopamine but not glutamate release in the nucleus accumbens. Eur J Neurosci 37:982–995. doi:10.1111/ejn.12121
Gearhardt A, Roberts M, Ashe M (2013) If sugar is addictive…what does it mean for the law? J Law Med Ethics 41(Suppl 1):46–49. doi:10.1111/jlme.12038
Gearhardt AN, Davis C, Kuschner R, Brownell KD (2011) The addiction potential of hyperpalatable foods. CDAR 4:140–145. doi:10.2174/1874473711104030140
Gekht AB, Polunina AG, Briun EA, Gusev EI (2003) Neurological disturbances in heroin addicts in acute withdrawal and early post-abstinence periods. Zh Nevrol Psikhiatr Im S S Korsakova 103:9–15
Genn RF, Ahn S, Phillips AG (2004) Attenuated dopamine efflux in the rat nucleus accumbens during successive negative contrast. Behav Neurosci 118:869–873. doi:10.1037/0735-7044.118.4.869
Goldstein RZ, Craig ADB, Bechara A et al (2009) The neurocircuitry of impaired insight in drug addiction. Trends Cognit Sci 13:372–380. doi:10.1016/j.tics.2009.06.004
Graham K, Vidal-Zeballos D (1998) Analyses of use of tranquilizers and sleeping pills across five surveys of the same population (1985–1991): the relationship with gender, age and use of other substances. Soc Sci Med 46:381–395
Grill HJ, Norgren R (1978) The taste reactivity test. II. Mimetic responses to gustatory stimuli in chronic thalamic and chronic decerebrate rats. Brain Res 143:281–297
Harris JL, Bargh JA, Brownell KD (2009) Priming effects of television food advertising on eating behavior. Health Psychol 28:404–413. doi:10.1037/a0014399
Hart C, Ward A, Haney M et al (2001) Methamphetamine self-administration by humans. Psychopharmacology 157:75–81. doi:10.1007/s002130100738
Hearst ES, Jenkins HM (1974) Sign tracking: the stimulus-reinforcer relation and directed action. Psychonmic Soc, Austin
Henry DJ, White FJ (1991) Repeated cocaine administration causes persistent enhancement of D1 dopamine receptor sensitivity within the rat nucleus accumbens. J Pharmacol Exp 258:882–890
Hernandez L, Hoebel BG (1988) Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens. Physiol Behav 44:599–606
Hiroi N, Brown JR, Haile CN et al (1997) FosB mutant mice: loss of chronic cocaine induction of fos-related proteins and heightened sensitivity to cocaine’s psychomotor and rewarding effects. Proc Natl Acad Sci USA 94:10397–10402. doi:10.2307/43218?ref=no-x-route:2c8ba5cf31f36df291c5a2097b853938
Hobbs M, Remington B, Glautier S (2005) Dissociation of wanting and liking for alcohol in humans: a test of the incentive-sensitisation theory. Psychopharmacology 178:493–499. doi:10.1007/s00213-004-2026-0
Hollis KL (1984) The biological function of Pavlovian conditioning: the best defense is a good offense. J Exp Psychol Anim Behav Process 10:413–425
Holmes NM, Marchand AR, Coutureau E (2010) Pavlovian to instrumental transfer: a neurobehavioural perspective. Neurosci Biobehav Rev 34:1277–1295. doi:10.1016/j.neubiorev.2010.03.007
Horger BA, Giles MK, Schenk S (1992) Preexposure to amphetamine and nicotine predisposes rats to self-administer a low dose of cocaine. Psychopharmacology 107:271–276
Hu X-T, Koeltzow TE, Cooper DC et al (2002) Repeated ventral tegmental area amphetamine administration alters dopamine D1 receptor signaling in the nucleus accumbens. Synapse 45:159–170. doi:10.1002/syn.10095
Hunt WA, Barnett LW, Branch LG (1971) Relapse rates in addiction programs. J Clin Psychol 27:455–456
Hyman SE, Malenka RC, Nestler EJ (2006) Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci 29:565–598. doi:10.1146/annurev.neuro.29.051605.113009
Isomura T, Suzuki J, Murai T (2014) Paradise Lost: The relationships between neurological and psychological changes in nicotine-dependent patients. Addict Res Theor 22:158–165. doi:10.3109/16066359.2013.793312
James W (1884) What is an Emotion? Mind 9:188–205. doi:10.2307/2246769?ref=no-x-route:661c887760fcf4a1f23afb46f8f75b0a
Jiang T, Soussignan R, Schaal B, Royet J-P (2014) Reward for food odors: an fMRI study of liking and wanting as a function of metabolic state and BMI. Soc Cogn Affect Neurosci. doi:10.1093/scan/nsu086
Johnson RJ, Segal MS, Sautin Y et al (2007) Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 86:899–906
Joutsa J, Johansson J, Niemelä S et al (2012) Mesolimbic dopamine release is linked to symptom severity in pathological gambling. Neuroimage 60:1992–1999. doi:10.1016/j.neuroimage.2012.02.006
Kalivas PW, Duffy P (1990) Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens. Synapse 5:48–58. doi:10.1002/syn.890050104
Kalivas PW, Duffy P (1993) Time course of extracellular dopamine and behavioral sensitization to cocaine. I. Dopamine axon terminals. J Neurosci off J Soc Neurosci 13:266–275
Kelly B, Hattersley L, King L, Flood V (2008) Persuasive food marketing to children: use of cartoons and competitions in Australian commercial television advertisements. Health Promot Int 23:337–344. doi:10.1093/heapro/dan023
Khantzian EJ (1985) The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. Am J Psychiatry 142:1259–1264
Khavari KA, Peters TC, Baity PL, Wilson AS (1975) Voluntary morphine ingestion, morphine dependence, and recovery from withdrawal signs. Pharmacol Biochem Behav 3:1093–1096
Kirkham T (2008) Endocannabinoids and the neurochemistry of gluttony. J Neuroendocrinol 20:1099–1100. doi:10.1111/j.1365-2826.2008.01762.x
Kirkham TC (2005) Endocannabinoids in the regulation of appetite and body weight. Behav Pharmacol 16:297–313
Kleber HD (2007) Pharmacologic treatments for opioid dependence: detoxification and maintenance options. Dialogues Clin Neurosci 9:455–470
Koob GF (1996) Drug addiction: the yin and yang of hedonic homeostasis. Neuron 16:893–896
Koob GF, Stinus L, le Moal M, Bloom FE (1989) Opponent process theory of motivation: neurobiological evidence from studies of opiate dependence. Neurosci Biobehav 13:135–140
Koob GF, Volkow ND (2010) Neurocircuitry of addiction. Neuropsychopharmacology 35:217–238. doi:10.1038/npp.2009.110
Lamb RJ, Preston KL, Schindler CW et al (1991) The reinforcing and subjective effects of morphine in post-addicts: a dose-response study. J Pharmacol Exp Ther 259:1165–1173
Lemmens SGT, Schoffelen PFM, Wouters L et al (2009) Eating what you like induces a stronger decrease of “wanting” to eat. Physiol Behav 98:318–325. doi:10.1016/j.physbeh.2009.06.008
Lenoir M, Serre F, Cantin L, Ahmed SH (2007) Intense sweetness surpasses cocaine reward. PLoS ONE 2:e698. doi:10.1371/journal.pone.0000698
Leyton M (2010) The neurobiology of desire: dopamine and the regulation of mood and motivational states in humans. In: Kringelbach ML, Berridge KC (eds) Pleasures of the Brain. Oxford University Press, New York, pp 222–243
Leyton M (2007) Conditioned and sensitized responses to stimulant drugs in humans. Prog Neuropsychopharmacol Biol Psychiatry 31:1601–1613. doi:10.1016/j.pnpbp.2007.08.027
Leyton M (2014) What’s deficient in reward deficiency? J Psychiatry Neurosci 39:291–293
Leyton M, Boileau I, Benkelfat C et al (2002) Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C]raclopride study in healthy men. Neuropsychopharmacology 27:1027–1035. doi:10.1016/S0893-133X(02)00366-4
Leyton M, Casey KF, Delaney JS et al (2005) Cocaine craving, euphoria, and self-administration: a preliminary study of the effect of catecholamine precursor depletion. Behav Neurosci 119:1619–1627. doi:10.1037/0735-7044.119.6.1619
Leyton M, Vezina P (2012) On cue: striatal ups and downs in addictions. Biol Psychiatry 72:e21–e22. doi:10.1016/j.biopsych.2012.04.036
Leyton M, Vezina P (2014) Dopamine ups and downs in vulnerability to addictions: a neurodevelopmental model. Trends Pharmacol Sci 35:268–276. doi:10.1016/j.tips.2014.04.002
Leyton M, Young SN, Blier P et al (2000) Acute tyrosine depletion and alcohol ingestion in healthy women. Alcohol Clin Exp Res 24:459–464
Linnet J, Møller A, Peterson E et al (2011) Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling. Addiction 106:383–390. doi:10.1111/j.1360-0443.2010.03126.x
Linnet J, Peterson E, Doudet DJ et al (2010) Dopamine release in ventral striatum of pathological gamblers losing money. Acta Psychiatr Scand 122:326–333. doi:10.1111/j.1600-0447.2010.01591.x
Litt A, Khan U, Shiv B (2010) Lusting while loathing: parallel counterdriving of wanting and liking. Psychol Sci 21:118–125. doi:10.1177/0956797609355633
Mahler SV, Berridge KC (2009) Which cue to “want?” Central amygdala opioid activation enhances and focuses incentive salience on a prepotent reward cue. J Neurosci 29:6500–6513. doi:10.1523/JNEUROSCI.3875-08.2009
Mendelson JH, Sholar M, Mello NK et al (1998) Cocaine tolerance: behavioral, cardiovascular, and neuroendocrine function in men. Neuropsychopharmacology 18:263–271. doi:10.1016/S0893-133X(97)00146-2
Mick I, Myers J, Stokes PRA, et al. (2014) Endogenous opioid release in pathological gamblers after an oral amphetamine challenge: a [11C] carfentanil pet study. Eur Neuropsychopharmacol 1–4
Miedl SF, Peters J, Büchel C (2012) Altered neural reward representations in pathological gamblers revealed by delay and probability discounting. Arch Gen Psychiatry 69:177–186. doi:10.1001/archgenpsychiatry.2011.1552
Munafò MR, Mannie ZN, Cowen PJ et al (2007) Effects of acute tyrosine depletion on subjective craving and selective processing of smoking-related cues in abstinent cigarette smokers. J Psychopharmacol (Oxford) 21:805–814. doi:10.1177/0269881107077216
Murdaugh D, Cook E (2012) fMRI reactivity to high-calorie food pictures predicts short- and long-term outcome in a weight-loss program. Neuroimage
Nijs IMT, Muris P, Euser AS, Franken IHA (2010) Differences in attention to food and food intake between overweight/obese and normal-weight females under conditions of hunger and satiety. Appetite 54:243–254. doi:10.1016/j.appet.2009.11.004
Nilsson J, Kristiansen TS, Fosseidengen JE et al (2008) Sign- and goal-tracking in Atlantic cod (Gadus morhua). Animal Behavior 11:651–659. doi:10.1007/s10071-008-0155-2
Ostafin BD, Marlatt GA, Troop-Gordon W (2010) Testing the incentive-sensitization theory with at-risk drinkers: wanting, liking, and alcohol consumption. Psychol Addict Behav 24:157–162. doi:10.1037/a0017897
Pandit R, de Jong JW, Vanderschuren LJMJ, Adan RAH (2011) Neurobiology of overeating and obesity: the role of melanocortins and beyond. Eur J Pharmacol 660:28–42. doi:10.1016/j.ejphar.2011.01.034
Paulson PE, Camp DM, Robinson TE (1991) Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats. Psychopharmacology 103:480–492. doi:10.1007/BF02244248
Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates, 6 edn. Elsevier, Amsterdam
Peciña S (2005) Hedonic hot spot in nucleus accumbens shell: where do μ-opioids cause increased hedonic impact of sweetness? J Neurosci 25:11777–11786. doi:10.1523/JNEUROSCI.2329-05.2005
Peciña S, Berridge KC (2013) Dopamine or opioid stimulation of nucleus accumbens similarly amplify cue-triggered “wanting” for reward: entire core and medial shell mapped as substrates for PIT enhancement. Eur J Neurosci. doi:10.1111/ejn.12174
Peciña S, Berridge KC, Parker LA (1997) Pimozide does not shift palatability: separation of anhedonia from sensorimotor suppression by taste reactivity. Pharmacol Biochem Behav 58:801–811
Peciña S, Cagniard B, Berridge KC et al (2003) Hyperdopaminergic mutant mice have higher “wanting” but not ‘liking’ for sweet rewards. J Neurosci 23:9395–9402
Peciña S, Schulkin J, Berridge KC (2006) Nucleus accumbens corticotropin-releasing factor increases cue-triggered motivation for sucrose reward: paradoxical positive incentive effects in stress? BMC Biol 4:8. doi:10.1186/1741-7007-4-8
Pfaus JG, Damsma G, Nomikos GG et al (1990) Sexual behavior enhances central dopamine transmission in the male rat. Brain Res 530:345–348
Piazza PV, Deminiere JM, le Moal M, Simon H (1990) Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration. Brain Res 514:22–26
Potenza MN (2008) The neurobiology of pathological gambling and drug addiction: an overview and new findings. Philos Trans Biol Sci 363:3181–3189
Purdy JE, Roberts AC, Garcia CA (1999) Sign tracking in cuttlefish (Sepia officinalis). J Comp Psychol 113:443–449
Reilly S, Schachtman TR (2009) Conditioned taste aversion: behavioral and neural processes. Oxford University Press, New York
Robbins TW, Watson BA, Gaskin M, Ennis C (1983) Contrasting interactions of pipradrol, d-amphetamine, cocaine, cocaine analogues, apomorphine and other drugs with conditioned reinforcement. Psychopharmacology 80:113–119
Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18:247–291
Robinson TE, Berridge KC (2003) Addiction. Annu Rev Psychol 54:25–53. doi:10.1146/annurev.psych.54.101601.145237
Robinson TE, Berridge KC (2008) The incentive sensitization theory of addiction: some current issues. Philos Trans R Soc, Biol Sci 363:3137–3146. doi:10.1098/rstb.2008.0093
Robinson TE, Jurson PA, Bennett JA, Bentgen KM (1988) Persistent sensitization of dopamine neurotransmission in ventral striatum (nucleus accumbens) produced by prior experience with (+)-amphetamine: a microdialysis study in freely moving rats. Brain Res 462:211–222
Robinson S, Sandstrom SM, Denenberg VH, Palmiter RD (2005) Distinguishing whether dopamine regulates liking, wanting, and/or learning about rewards. Behav Neurosci 119:5–15. doi:10.1037/0735-7044.119.1.5
Robinson MJF, Robinson TE, Berridge KC (2013) Incentive salience and the transition to addiction. Elsevier, Amsterdam, pp 391–399
Robinson MJF, Anselme P, Fischer AM, Berridge KC (2014a) Initial uncertainty in Pavlovian reward prediction persistently elevates incentive salience and extends sign-tracking to normally unattractive cues. Behav Brain Res 266:119–130. doi:10.1016/j.bbr.2014.03.004
Robinson MJF, Warlow SM, Berridge KC (2014b) Optogenetic excitation of central amygdala amplifies and narrows incentive motivation to pursue one reward above another. J Neurosci 34:16567–16580. doi:10.1523/JNEUROSCI.2013-14.2014
Robinson MJF, Anselme P, Suchomel K, Berridge KC (2015a) Amphetamine-induced sensitization and reward uncertainty similarly enhance incentive salience for conditioned cues. Behav Neurosci. doi:10.1037/bne0000064
Robinson MJF, Burghardt PR, Patterson CM et al (2015b) Individual differences in cue-induced motivation and striatal systems in rats susceptible to diet-induced obesity. Neuropsychopharmacology, epub ahead of print:1–11. doi:10.1038/npp.2015.71
Robinson TE, Yager LM, Cogan ES, Saunders BT (2014c) On the motivational properties of reward cues: individual differences. Neuropharmacology 76 Pt B:450–459. doi:10.1016/j.neuropharm.2013.05.040
Rose JE, Behm FM, Westman EC, Johnson M (2000) Dissociating nicotine and nonnicotine components of cigarette smoking. Pharmacol Biochem Behav 67:71–81
Rosse RB, Fay-McCarthy M, Collins JP et al (1993) Transient compulsive foraging behavior associated with crack cocaine use. Am J Psychiatry 150:155–156
Rozin P (2000) Disgust. In: Lewis M, Haviland-Jones JM (eds) Handbook of emotions. Guilford, New York, pp 637–653
Rømer Thomsen K, Fjorback LO, Møller A, Lou HC (2014) Applying incentive sensitization models to behavioral addiction. Neurosci Biobehav Rev 45C:343–349. doi:10.1016/j.neubiorev.2014.07.009
Sáinz N, Barrenetxe J, Moreno-Aliaga MJ, Martínez JA (2015) Leptin resistance and diet-induced obesity: central and peripheral actions of leptin. Metab, Clin Exp 64:35–46. doi:10.1016/j.metabol.2014.10.015
Schulte EM, Avena NM, Gearhardt AN (2015) Which foods may be addictive? The roles of processing, fat content, and glycemic load. PLoS ONE 10:e0117959. doi:10.1371/journal.pone.0117959
Shin AC, Townsend RL, Patterson LM, Berthoud H-R (2011) “Liking” and “wanting” of sweet and oily food stimuli as affected by high-fat diet-induced obesity, weight loss, leptin, and genetic predisposition. AJP: Regulatory. Integr Comp Physiol 301:R1267–R1280. doi:10.1152/ajpregu.00314.2011
Shuster L, Webster GW, Yu G (1975) Increased running response to morphine in morphine-pretreated mice. J Pharmacol Exp Ther 192:64–67
Shuster L, Yu G, Bates A (1977) Sensitization to cocaine stimulation in mice. Psychopharmacology 52:185–190
Singer BF, Scott-Railton J, Vezina P (2012) Unpredictable saccharin reinforcement enhances locomotor responding to amphetamine. Behav Brain Res 226:340–344. doi:10.1016/j.bbr.2011.09.003
Small DM, Zatorre RJ, Dagher A et al (2001) Changes in brain activity related to eating chocolate: from pleasure to aversion. Brain 124:1720–1733
Smith KS, Berridge KC (2007) Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum. J Neurosci 27:1594–1605. doi:10.1523/JNEUROSCI.4205-06.2007
Smith KS, Mahler SV, Peciña S, Berridge KC (2007) Hedonic hotspots: Generating sensory pleasure in the brain. In: Kringelbach ML, Berridge KC (eds) Pleasures of the brain. Oxford University Press, Oxford, pp 1–35
Steiner JE, Glaser D, Hawilo ME, Berridge KC (2001) Comparative expression of hedonic impact: affective reactions to taste by human infants and other primates. Neurosci Biobehav Rev 25:53–74
Stinus L, Robert C, Karasinski P, Limoge A (1998) Continuous quantitative monitoring of spontaneous opiate withdrawal: locomotor activity and sleep disorders. Pharmacol Biochem Behav 59:83–89
Stolerman IP (1985) Motivational effects of opioids: evidence on the role of endorphins in mediating reward or aversion. Pharmacol Biochem Behav 23:877–881
Swanson LW (2000) Cerebral hemisphere regulation of motivated behavior. Brain Res 886:113–164
Swanson LW (2005) Anatomy of the soul as reflected in the cerebral hemispheres: neural circuits underlying voluntary control of basic motivated behaviors. J Comp Neurol 493:122–131. doi:10.1002/cne.20733
Tang DW, Fellows LK, Small DM, Dagher A (2012) Food and drug cues activate similar brain regions: a meta-analysis of functional MRI studies. Physiol Behav 106:317–324. doi:10.1016/j.physbeh.2012.03.009
Tindell AJ, Berridge KC, Zhang J et al (2005) Ventral pallidal neurons code incentive motivation: amplification by mesolimbic sensitization and amphetamine. Eur J Neurosci 22:2617–2634. doi:10.1111/j.1460-9568.2005.04411.x
van Holst RJ, Veltman DJ, Büchel C et al (2012) Distorted expectancy coding in problem gambling: is the addictive in the anticipation? Biol Psychiatry 71:741–748. doi:10.1016/j.biopsych.2011.12.030
Vanderschuren LJ, De Vries TJ, Wardeh G et al (2001) A single exposure to morphine induces long-lasting behavioural and neurochemical sensitization in rats. Eur J Neurosci 14:1533–1538
Vanderschuren LJ, Kalivas PW (2000) Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies. Psychopharmacology 151:99–120
Vezina P (1993) Amphetamine injected into the ventral tegmental area sensitizes the nucleus accumbens dopaminergic response to systemic amphetamine: an in vivo microdialysis study in the rat. Brain Res 605:332–337
Vezina P (2004) Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychomotor stimulant drugs. Neurosci Biobehav Rev 27:827–839. doi:10.1016/j.neubiorev.2003.11.001
Vezina P, Leyton M (2009) Conditioned cues and the expression of stimulant sensitization in animals and humans. Neuropharmacology 56(Suppl 1):160–168. doi:10.1016/j.neuropharm.2008.06.070
Volkow ND, Wang G-J, Fowler JS et al (2002) “Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect. Synapse 44:175–180. doi:10.1002/syn.10075
Volkow ND, Wang GJ, Fowler JS et al (1997) Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects. Nature 386:830–833. doi:10.1038/386830a0
Wachtel SR, Ortengren A, de Wit H (2002) The effects of acute haloperidol or risperidone on subjective responses to methamphetamine in healthy volunteers. Drug Alcohol Depend 68:23–33
West R (2009) The multiple facets of cigarette addiction and what they mean for encouraging and helping smokers to stop. COPD 6:277–283. doi:10.1080/15412550903049181
Wikler A (1973) Dynamics of drug dependence: Implications of a conditioning theory for research and treatment. Arch Gen Psychiatry 28:611–616
Wilkinson CJ (1998) The abuse potential of zolpidem administered alone and with alcohol. Pharmacol Biochem Behav 60:193–202
Winkielman P, Berridge KC (2003) Irrational wanting and subrational liking: how rudimentary motivational and affective processes shape preferences and choices. Polit Psychol 24:657–680. doi:10.2307/3792260?ref=no-x-route:d779aaa6e949d52d4e89ed4f70b1996e
Winkielman P, Berridge KC, Wilbarger JL (2005) Unconscious affective reactions to masked happy versus angry faces influence consumption behavior and judgments of value. Pers Soc Psychol Bull 31:121–135. doi:10.1177/0146167204271309
Wise RA (1982) Neuroleptics and operant behavior: The anhedonia hypothesis. Behav Brain Sci 5:39–53
Woolverton WL, Cervo L, Johanson CE (1984) Repeated methamphetamine administration on methamphetamine self-administration in rhesus monkeys. Pharmacol Biochem Behav 21:737–741. doi:10.1016/S0091-3057(84)80012-X
Wyvell CL, Berridge KC (2000) Intra-accumbens amphetamine increases the conditioned incentive salience of sucrose reward: enhancement of reward “wanting” without enhanced “liking” or response reinforcement. J Neurosci 20:8122–8130
Wyvell CL, Berridge KC (2001) Incentive sensitization by previous amphetamine exposure: increased cue-triggered “wanting” for sucrose reward. J Neurosci 21:7831–7840
Yokum S, Gearhardt AN, Harris JL, et al. (2014) Individual differences in striatum activity to food commercials predict weight gain in adolescents. Obesity doi:10.1002/oby.20882
Yokum S, Ng J, Stice E (2011) Attentional bias to food images associated with elevated weight and future weight gain: an fMRI study. Obesity 19:1775–1783. doi:10.1038/oby.2011.168
Zack M, Featherstone RE, Mathewson S, Fletcher PJ (2014) Chronic exposure to a gambling-like schedule of reward predictive stimuli can promote sensitization to amphetamine in rats. Front Behav Neurosci 8:36. doi:10.3389/fnbeh.2014.00036
Zhang J, Berridge KC, Tindell AJ et al (2009) A neural computational model of incentive salience. PLoS Comput Biol 5:e1000437. doi:10.1371/journal.pcbi.1000437
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Robinson, M.J.F., Fischer, A.M., Ahuja, A., Lesser, E.N., Maniates, H. (2015). Roles of “Wanting” and “Liking” in Motivating Behavior: Gambling, Food, and Drug Addictions. In: Simpson, E., Balsam, P. (eds) Behavioral Neuroscience of Motivation. Current Topics in Behavioral Neurosciences, vol 27. Springer, Cham. https://doi.org/10.1007/7854_2015_387
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