Abstract
Aging and menopause are closely related to hormonal and metabolic changes. Vitamin D is a crucial factor modulating several metabolic processes. The aim of this study was to evaluate biomarkers of bone metabolism in peri- and postmenopausal women with obstructive lung diseases. Sixty two female patients, 27 with asthma and 35 with COPD, aged over 45 years (median age 58 and 64 years, respectively) were enrolled into the study. The evaluation included lung function, bone mineral density, serum concentration of vitamin D, and bone metabolism markers. The study groups differed significantly in terms of forced expiratory volume in 1 s (FEV1); median values of 1.79 L vs. 1.16 L (p = 0.0001) and 71.2% vs. 53.0% predicted (p = 0.0072) and in vitamin D concentration (12.3 ng/ml vs. 17.6 ng/ml). Total bone mineral density (BMD) was lower in the COPD group (p = 0.0115). Serum vitamin D inversely correlated with the number of pack-years in asthma patients (r = −0.45, p = 0.0192). There was no correlation between serum vitamin D and disease duration or severity, and the Asthma Control Test (ACT) and the modified Medical Research Council (mMRC) dyspnea scores. The serum bone metabolism markers C-terminal cross-linked telopeptide of collagen type I (BCROSS), N-terminal propeptides of procollagen type-1 (tP1NP), and N-mid osteocalcin (OCN) inversely correlated with age in the COPD, but not asthma, patients (r = −0.38, p = 0.0264; r = −0.37, p = 0.0270; and r = −0.42, p = 0.0125, respectively). We conclude that peri- and postmenopausal women with obstructive lung diseases had a decreased serum concentration of vitamin D. Furthermore, vitamin D and body mineral density were appreciably lower in women with COPD than those with asthma.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Arshi S, Fallahpour M, Nabavi M, Bemanian MH, Javad-Mousavi SA, Nojomi M, Esmaeilzadeh H, Molatefi R, Rekabi M, Jalali F, Akbarpour N (2014) The effects of Vitamin D supplementation on airway functions in mild to moderate persistent asthma. Ann Allergy Asthma Immunol 113:404–440
Brumpton BM, Langhammer A, Henriksen AH, Camargo CA Jr, Chen Y, Romundstad PR, Mai XM (2016) Vitamin D and lung function decline in adults with asthma: the HUNT Study. Am J Epidemiol 183:739–746
Cassim R, Russell MA, Lodge CJ, Lowe AJ, Koplin JJ, Dharmage SC (2015) The role of circulating 25 hydroxyvitamin D in asthma: a systematic review. Allergy 70:339–354
Confino-Cohen R, Brufman I, Goldberg A, Feldman BS (2014) Vitamin D, asthma prevalence and asthma exacerbations: a large adult population-based study. Allergy 69:1673–1680
Esfandiar N, Alaei F, Fallah S, Babaie D, Sedghi N (2016) Vitamin D deficiency and its impact on asthma severity in asthmatic children. Ital J Pediatr 42:108
GINA (2010) Global initiative for Asthma. Global strategy for Asthma management and prevention updated 2016. http:www.ginasthma.org/2010. Accessed on 23 Nov 2017
GOLD (2010) Global initiative for chronic obstructive lung disease. Global strategy for the diagnosis, management and prevention of COPD. Updated 2017. http:www.goldcopd.org. Accessed on 23 Nov 2017
Graat-Verboom L, Smeenk FW, van den Borne BE, Spruit MA, Jansen FH, van Enschot JW, Wouters EF (2012) Progression of osteoporosis in patients with COPD: a 3-year follow up study. Respir Med 106:861–870
Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, Sherman S, Sluss PM, de Villiers TJ (2012) Executive summary of the stages of reproductive aging workshop +10: addressing the unfinished agenda of staging reproductive aging. J Clin Endocrinol Metab 97:1159–1168
Janssens W, Mathieu C, Boonen S, Decramer M (2011) Vitamin D deficiency and chronic obstructive pulmonary disease: a vicious circle. Vitam Horm 86:379–399
Janssens W, Decramer M, Mathieu C, Korf H (2013) Vitamin D and chronic obstructive pulmonary disease: hype or reality? Lancet Respir Med 1:804–812
Jiao J, King TS, McKenzie M, Bacharier LB, Dixon AE, Codispoti CD, Dunn RM, Grossman NL, Lugogo NL, Ramratnam SK, Traister RS, Wechsler ME, Castro M (2016) Vitamin D3 therapy in patients with asthma complicated by sinonasal disease: secondary analysis of the Vitamin D add-on therapy enhances corticosteroid responsiveness in asthma trial. J Allergy Clin Immunol 1:589–592
Kaczmarek M (2007) Estimation of the age at natural menopause in a population-based study of Polish women. Przegląd Menopauzalny 2:77–82. (Article in polish)
Keating P, Munim A, Hartmann JX (2014) Effect of Vitamin D on T-helper type 9 polarized human memory cells in chronic persistent asthma. Ann Allergy Asthma Immunol 112:154–162
Korn S, Hübner M, Jung M, Blettner M, Buhl R (2013) Severe and uncontrolled adult asthma is associated with vitamin D insufficiency and deficiency. Respir Res 14:15
Larose TL, Langhammer A, Chen Y, Camargo CA Jr, Romundstad P, Mai XM (2015) Serum 25-hydroxyvitamin D levels and lung function in adults with asthma: the HUNT Study. Eur Respir J 45:1019–1026
Li P, Ghazala L, Wright E, Beach J, Morrish D, Vethanayagam D (2015) Prevalence of osteopenia and osteoporosis in patients with moderate to severe asthma in Western Canada. Clin Invest Med 38:23–30
Martineau AR, James WY, Hooper RL, Barnes NC, Jolliffe DA, Greiller CL, Islam K, McLaughlin D, Bhowmik A, Timms PM, Rajakulasingam RK, Rowe M, Venton TR, Choudhury AB, Simcock DE, Wilks M, Degun A, Sadique Z, Monteiro WR, Corrigan CJ, Hawrylowicz CM, Griffiths CJ (2015) Vitamin D3 supplementation in patients with chronic obstructive pulmonary disease (ViDiCO): a multicentre, double blind, randomised controlled trial. Lancet Respir Med 3:120–130
Moberg M, Ringbaek T, Roberts NB, Vestbo J (2014) Association between vitamin D status and COPD phenotypes. Lung 192:493–497
Odler B, Ivancsó I, Somogyi V, Benke K, Tamási L, Gálffy G, Szalay B, Müller V (2015) Vitamin D deficiency is associated with impaired disease control in asthma-COPD overlap syndrome patients. Int J Chron Obstruct Pulmon Dis 10:2017–2025
Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, Coates A, van der Grinten CP, Gustafsson P, Hankinson J, Jensen R, Johnson DC, MacIntyre N, McKay R, Miller MR, Navajas D, Pedersen OF, Wanger J (2005) Interpretative strategies for lung function tests. Eur Respir J 26:948–968
Persson LJ, Aanerud M, Hiemstra PS, Hardie JA, Bakke PS, Eagan TM (2012) Chronic obstructive pulmonary disease is associated with low levels of vitamin D. PLoS One 7:e38934
Płudowski P, Karczmarewicz E, Bayer M et al (2013) Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe – recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol Pol 64:319–327
Schnell K, Weiss CO, Lee T, Krishnan JA, Leff B, Wolff JL, Boyd C (2012) The prevalence of clinically-relevant comorbid conditions in patients with physician-diagnosed COPD: a cross-sectional study using data from NHANES 1999–2008. BMC Pulm Med 12:26
Silva DR, Coelho AC, Dumke A, Valentini JD, de Nunes JN, Stefani CL, da Silva Mendes LF, Knorst MM (2011) Osteoporosis prevalence and associated factors in patients with COPD: a cross-sectional study. Respir Care 56:961–968
Sweeney J, Patterson CC, Menzies-Gow A, Niven RM, Mansur AH, Bucknall C, Chaudhuri R, Price D, Brightling CE, Heaney LG (2016) Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the optimum patient care research database and the British Thoracic Difficult Asthma Registry. Thorax 71:339–346
Vasikaran S, Eastell R, Bruyère O, Foldes AJ, Garnero P, Griesmacher A, McClung M, Morris HA, Silverman S, Trenti T, Wahl DA, Cooper C, Kanis JA (2011) Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Osteoporos Int 22:391–420
Veldurthy V, Wei R, Oz L, Dhawan P, Jeon YH, Christakos S (2016) Vitamin D, calcium homeostasis and aging. Bone Res 4:16041
Xiaomei W, Hang X, Lingling L, Xuejun L (2014) Bone metabolism status and associated risk factors in elderly patients with chronic obstructive pulmonary disease (COPD). Cell Biochem Biophys 70:129–134
Zendedel A, Gholami M, Anbari K, Ghanadi K, Bachari EC, Azargon A (2015) Effects of Vitamin D intake on FEV1 and COPD exacerbation: a randomized clinical trial study. Glob J Health Sci 7:243–248
Conflicts of Interest
The authors declare no conflicts of interest in relation to this article.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this chapter
Cite this chapter
Białek-Gosk, K., Rubinsztajn, R., Białek, S., Paplińska-Goryca, M., Krenke, R., Chazan, R. (2018). Serum Vitamin D Concentration and Markers of Bone Metabolism in Perimenopausal and Postmenopausal Women with Asthma and COPD. In: Pokorski, M. (eds) Progress in Medical Research. Advances in Experimental Medicine and Biology(), vol 1070. Springer, Cham. https://doi.org/10.1007/5584_2018_157
Download citation
DOI: https://doi.org/10.1007/5584_2018_157
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-89664-9
Online ISBN: 978-3-319-89665-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)