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NPY in alcoholism and psychiatric disorders

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NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics

Part of the book series: Experientia Supplementum ((EXS,volume 95))

Conclusion

The NPY system may well be one of the most interesting target systems for development of treatments for alcohol dependence as well as mood disorders such as depression and anxiety syndromes. NPY is an endogenous anxiolytic compound, functions as an antidepressant, and is effective in modifying alcohol intake in high drinking states. Through receptor subtype specific compounds, the NPY system offers an interesting and innovative future approach for treatment designs. Selective Y2 receptor antagonists and/or Y1 agonists that are peripherally available and effectively penetrate the CNS are possible candidates. In conclusion, the NPY system offers attractive targets for development of future treatments for depression, anxiety, and alcohol dependence.

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Authors and Affiliations

  1. NIH/NIAAA, LCS, Building 10-CRC/Room 1-5330, 10 Center Drive, Bethesda, Maryland, 20892, USA

    Annika Thorsell, Rose-Marie Karlsson & Markus Heilig

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  1. Annika Thorsell
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  2. Rose-Marie Karlsson
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  3. Markus Heilig
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Editors and Affiliations

  1. Department of Physiology and Biophysics, Georgetown University Medical Center, 3900 Reservoir Rd., NW, Washington, DC, 20057, USA

    Zofia Zukowska

  2. Wyeth Research, Building A3153, 500 Arcola Rd, Collegeville, PA, 19426, USA

    Giora Z. Feuerstein

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Thorsell, A., Karlsson, RM., Heilig, M. (2006). NPY in alcoholism and psychiatric disorders. In: Zukowska, Z., Feuerstein, G.Z. (eds) NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders: from Genes to Therapeutics. Experientia Supplementum, vol 95. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7417-9_14

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