Abstract
Simulated Moving Bed (SMB) technology is of rising interest in the field of bioseparation. This is particularly due to its advantages such as reduction of solvent consumption, high productivity and final purities as well as low investment costs in comparison to eluent chromatography. SMB units can operate under high productivity overloaded conditions. This leads to nonlinear competitive adsorption behavior, which has to be accounted for when designing and optimizing new SMB separations. The so called “Triangle Theory”, which is briefly reviewed in this chapter, provides explicit criteria for the choice of the operating conditions of SMB units to achieve the prescribed separation of a mixture characterized by Langmuir, modified Langmuir and bi-Langmuir isotherms.
The application of the SMB-technique to the downstream processing of biotechnological products requires some specific changes to meet the special demands of bioproduct isolation. Some exemplary applications are given including separations of sugars, proteins,monoclonal antibodies, ionic molecules and optical isomers and for desalting.
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References
Pröll T, Küsters E (1998) J. Chromatogr. A 800:135
Broughton DB (1961) US Patent 2 985 589
Balannec B, Hotier G (1993) From batch to countercurrent chromatography. In: Ganetsos G, Barker PE (eds) Preparative and Production Scale Chromatography, Marcel Decker, New York
Nicoud RM (1998) Simulated Moving Bed (SMB): Some Possible Applications for Biotechnology. In: Subramanian G (ed) Bioseparation and Bioprocessing, Wiley-VCH, Weinheim-New York
Blehaut J, Nicoud RM (1998) Analysis 26:M60
Nicoud RM, Fuchs G, Adam P, Bailly M, Küsters E, Antia FD, Reuille R, Schmid E (1993) Chirality 5:267
Nicoud RM, Bailly M, Kinkel JN, Devant R, Hampe T, Küsters E (1993) In: Nicoud RM (ed) Simulated Moving Bed: Basics and Applications, INPL, Nancy, France, p 65
Küsters E, Gerber G, Antia FD (1995) Chromatographia 40:387
Blehaut J, Charton F, Nicoud RM (1996) LC-GC Intl 9:228
Schulte M, Britsch L, Strube J (2000) Acta Biotechnol 20:3
Guiochon G, Golshan Shirazi S, Katti AM (1994) Fundamentals of preparative and nonlinear chromatography, Academic Press, Boston
Nicoud RM, Blehaut J, Charton F (1995) J. Chromatogr. 702:97
Strube J, Altenhöner U, Meurer M, Schmidt-Traub H (1997) Chem.Ing.Tech. 69:328
Morbidelli M, Mazzotti M, Pedeferri M (1996) Chiral Europe 96, Symposium Proceedings 103
Mazzotti M, Storti G, Morbidelli M (1997) J. Chromatogr. 769:3
Van Tassel PR, Viot P, Tarjus G (1997) J. Chem. Phys. 106:761
Hotier G, Cohen C, Couenne N, Nicoud RM (1996) US Patent 5 578 216
Charton F, Nicoud RM (1995) J. Chromatogr. A 702:97
Migliorini C, Mazzotti M, Morbidelli M (1998) J. Chromatogr. A 827:161
Storti G, Mazzotti M, Morbidelli M, Carrà S (1993) AIChE J.39:471
Mazzotti M, Storti G, Morbidelli M (1994) AIChE J. 40:1825
Storti G, Baciocchi R, Mazzotti M, Morbidelli M (1995) Ind. Eng. Chem. Res. 34:288
Mazzotti M, Storti G, Morbidelli M (1996) AIChE J. 42:2784
Mazzotti M, Storti G, Morbidelli M (1997) AIChE J. 43:64
Mazzotti M, Storti G, Morbidelli M (1997) J. Chromatogr. A 769:3
Chiang AST (1998) AIChE J. 44:332
Gentilini A, Migliorini C, Mazzotti M, Morbidelli M (1998) J. Chromatogr. A 805:37
Zhong G, Guiochon G (1997) Chem. Eng. Sci. 52:4403
Ruthven DM, Ching CB (1989) Chem. Eng. Sci. 44:1011
Charton F, Nicoud RM (1995) J. Chromatogr. A 702:97
Migliorini C, Gentilini A, Mazzotti M, Morbidelli M (1998) Ind. Eng. Chem. Res.
Barker PE, Critcher X (1960) Chem. Eng. Sci. 13:82
Hashimoto K, Adashi S, Noujima H, Maruyama H (1983) J. Chem. Eng. Jpn 16:400
Ching CB, Ruthven DM (1985) Chem. Eng. Sci. 40:877
Ching CB, Ruthven DM, Hidajat K (1985) Chem. Eng. Sci. 40:1411
Hashimoto K, Adachi S, Shirai Y, Mortshita M (1992) Operation and Design of Simulated Moving Bed Adsorbers. In: Ganetsos G, Barker PE (eds) Preparative and Production Scale Chromatography, Marcel Dekker, New York
Blezer HJ, De Rosset AJ (1977) Die Starke 29:393
Kishihara S, Horikawa H, Tamaki H, Fujii S, Nakajima Y, Nishio K (1989) J. Chem. Eng. Jpn 22:434
Ganetsos G, Barker PE (1993) (eds) Preparative and Production Scale Chromatography, Marcel Dekker, New York
Maki H, Fukuda H, Morikawa H (1987) J.Ferment.Technol. 65:61
Hashimoto K, Adachi S, Shirai Y (1988) Agric. Biol. Chem. 52:2161
Huang SY, Lin CK, Chang WH, Lee WS (1986) Chem. Eng. Commun. 456:291
Houwing J, van der Wielen LAM, Luyben KChM (1996) Proceeding of the First European Symposium on Biochemical Engineering Science, Delft University, The Netherlands, ISBN 1872327109, Dublin
Nicoud RM (1996) Recovery of Biological Products VIII, ACS, Tuscon, Arizona
Gottschlich N, Kasche V (1997) J. Chromatogr. A 765:201
Van Walsem HJ, Thompson MC (1996) First European Symposium on Biochemical Engineering Science, AECI Bioproducts, Durban, South Africa, ISBN 1872327109, Dublin
Kampen WH, European Patent application, 90307701.4
Maki H (1992) In: Ganetsos G, Barker PE (eds) Preparative and Production Scale Chromatography. Marcel Dekker, New York
Szpepy L, Sebestyen Zs, Feher I, Nagy Z (1975) J. Chromatogr. 108:285
Kinkel JN (1995) Proceedings of Chiral Europe’ 95, London, Published by Spring Innovation Ltd., Cheshire, SK7 1BA, England
Ching CB, Lim BG, Lee EJD, Ng SC (1993) J. Chromatogr. 634:215
Ikeda H, Murata K (1993) 4th Chiral Symposium Montreal
Negawa M, Shoji F (1992) J. Chromatogr. 590:113
Fuchs G, Nicoud RM, Bailly M (1992) In: Proceedings of the 9th Symposium on Preparative and Industrial Chromatography “Prep 92”, INPL, Nancy, France, p 205
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Imamoglu, S. (2002). Simulated Moving Bed Chromatography (SMB) for Application in Bioseparation. In: Freitag, R. (eds) Modern Advances in Chromatography. Advances in Biochemical Engineering/Biotechnology, vol 76. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45345-8_6
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DOI: https://doi.org/10.1007/3-540-45345-8_6
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