17.7 Summary
In the last decade typical signs of spinal cord ischemia have been reported. Confirming and supporting signs of acute ischemic myelomalacia are vertebral body infarction and the pathognomonic contrast enhancement of the cauda equina in the course of the disease. Moreover, bone infarction strongly indicates the proximal occlusion and the level of the affected segmental artery. Cartilaginous disc embolism, embolism following periradicular nerve root therapy and compression of a lumbar artery are underestimated causes of spinal cord ischemia.
In most cases a long, extending cord lesion in the presence of perimedullary veins favors spinal dural AV fistulas as an underlying disorder which has to be confirmed by spinal angiography and separated from perimedullary AV fistulas. Up to now, it is not possible to differentiate local arterial from venous occlusion in the intravital diagnostic work-up. MRI, MR angiography and spinal DSA are complementary diagnostic tools in vascular diseases of the spinal cord which help us to confirm the diagnosis and to come to a better understanding of these rare disorders.
In summary, important advances have been made in our understanding of the underlying pathogenetic mechanism in spinal cord ischemia. This condition remains a diagnostic and therapeutic challenge, but improved diagnosis may result in better treatment in the future.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Amano Y, Machida T, Kumazaki T (1998) Spinal cord infarcts with contrast enhancement of the cauda equina: two cases. Neuroradiology 40:669–672
Aminoff MJ, Barnard RO, Logue V (1974) The pathophysiology of spinal vascular malformations. J Neurol Sci 23:255–263
Backes W, Nijenhuis R, Mull M, Thron A, Wilmink J (2004) Contrast-Enhanced MR Angiography of the Spinal Arteries: Current Possibilities and Limitations. Rivista di Neuroradiologia 17(3):282–291
Bammer R, Fazekas F, Augustin M, Simbrunner J, Strasser-Fuchs S, Seifert T, Stollberger R, and Hartung HP (2000) Diffusion-weighted MR imaging of the spinal cord. AJNR Am J Neuroradiol 21(3):587–591
Behrens S, Thron A (1999) Long-term follow-up and outcome in patients treated for spinal dural arteriovenous fistula. J Neurol 246:181–185
Berlit P, Klötzsch G, Röther J, Assmus HP, Daffertshofer M, Schwartz A (1992) Spinal cord infarction: MRI and MEP findings in three cases. J Spinal Disord 5:212–216
Binkert CA, Kollias SS, Valavanis A (1999) Spinal cord vascular disease: characterization with fast three-dimensional contrast-enhanced MR Angiography. Am J Neuroradiol 20:1785–1793
Bowen BC, DePrima S, Pattany PM, Marcillo A, Madsen P, Quencer RM (1996) MR angiography of normal intradural vessels of the thoracolumbar spine. AJNR Am J Neuroradiol 17:483–494
Brown E, Virapongse C, and Gregorios JB (1998) MR imaging of cervical spinal cord infarction. J Comput.Assist.Tomogr. 13(5):920–922
Burguet JL, Dietemann JL, Wackenheim A, Kehr P, Buchheit F (1985) Sacral meningeal arteriovenous fistula fed by branches of the hypogastric arteries and drained through medullary veins. Neuroradiology 27:232–237
Caplan L (2003) Spinal Cord Ischemia. In: Neurological Disorders: Course and Treatment, Second Edition, Elsevier Science:393–401.
Casselman JW, Jolie E, Dehaene I, Meeus L (1991) Gadolinium-enhanced MR imaging of infarction of the anterior spinal cord. AJNR Am J Neuroradiol 12:561
Cheshire WP, Santos CC, Massey EW, Howard JF (1996) Spinal cord infarction: etiology and outcome. Neurology 47:321–330
de Seze J, Stojkovic T, Breteau G, Lucas C, Michon-Pasturel U, Gauvrit JY, Hachulla E, Mounier-Vehier F, Pruvo JP, Leys D, Destée A, Hatron PY, Vermersch P (2001) Acute myelopathies: Clinical, laboratory and outcome profiles in 79 cases. Brain 124:1509–1521
Di Chiro G, Wener L (1973) Angiography of the spinal cord. A review of contemporary techniques and applications. J Neurosurg 39:1–29
Djindjian R, Hurth M, and Houdart R (1970) L’angiographie de la moelle epiniere. Masson, Paris
Dormont D, Gelbert F, Assouline E, Reizine D, Helias A, Riche MC, Chiras J, Bories J, Merland JJ (1988) MR imaging of spinal cord arteriovenous malformations at 0. 5 T: study of 34 cases. AJNR Am J Neuroradiol 9:833–838
Duggal N, Lach B (2002) Selective vulnerability of the lumbosacral spinal cord after cardiac arrest and hypotension. Stroke 33:116–121
Faig J, Busse O, Salbeck R (1998) Vertebral body infarction as a confirmatory sign of spinal cord ischemic stroke: report of three cases and review of the literature. Stroke 29:239–243
Farb RI, Kim JK, Willinsky RA, Montanera WJ, terBrugge K, Derbyshire JA, van Dijk JMC, and Wright GA (2002) Spinal dural arteriovenous fistula localization with a technique of first-pass gadolinium-enhanced MR angiography: initial experience. Radiology 222:843–850
Friedman DP, Flanders AE (1992) Enhancement of gray matter in anterior spinal infarction. AJNR Am J Neuroradiol 13:983–985
Gass A, Back T, Behrens S, Maras A (2000) MRI of spinal cord infarction. Neurology 54:2195
Gilbertson JR, Miller GM, Goldman MS, Marsh WR (1995) Spinal dural arteriovenous fistulas: MR and myelographic findings. AJNR Am J Neuroradiol 16:2049–2057
Gravereaux EC, Faries PL, Burks JA, Latessa V, Spielvogel D, Hollier LH, Marin ML (2001) Risk of spinal cord ischemia after endograft repair of thoracic aortic aneurysms. J Vasc Surg 34:997–1003
Haddad MC, Aabedal-Thagafi MY, Djurberg H (1996) MRI of spinal cord and vertebral body infarction in the anterior spinal artery syndrome. Neuroradiology 38:161–162
Hassler W, Thron A, Grote EH (1989) Hemodynamics of spinal dural arteriovenous fistulas. An intraoperative study. J Neurosurg 70:360–370
Heindel CC, G.S. Dugger, F.C. Guinto (1975) Spinal arteriovenous malformation with hypogastric blood supply. J. Neurosurg. 42, 462–464
Heros RC, Debrun GM, Ojemann RG, Lasjaunias PL, Naessens PJ (1986) Direct spinal arteriovenous fistula: a new type of spinal AVM. Case report. J Neurosurg 64:134–139
Hirono H, Yamadori A, Komiyama M, Yakura H, Yasui T (1992) MRI of spontaneous spinal cord infarction: serial changes in gadolinium-DTPA enhancement. Neuroradiology 34:95–97
Huffmann BC, Gilsbach JM, Thron A (1995) Spinal dural arteriovenous fistulas: a plea for neurosurgical treatment. Acta Neurochir (Wien) 135:44–51
Hurst R.W., and Grossman RI (2000) Peripheral spinal cord hypodensity on T2-weighted MR images: a reliable imaging sign of venous hypertensive myelopathy. AJNR Am J Neuroradiol 21:781–786
Kadyi H (1889) Über die Blutgefäße des menschlichen Rückenmarks. Gubrynowicz u. Schmidt, Lemberg
Kendall BE, Logue V (1977) Spinal epidural angiomatous malformations draining into intrathecal veins. Neuroradiology 13:181–189
Koch C, Hansen HC, Westphal M, Kucinski T, Zeumer H (1998) Die kongestive Myelopathie durch spinale durale arteriovenöse Fisteln. Nervenarzt 69:279–286
Koenig E, Thron A, Schrader V, Dichgans J (1989) Spinal arteriovenous malformations and fistulae: clinical, neuroradiological and neurophysiological findings. J Neurol 236:260–266
Kueker W, Weller M, Klose U, Krapf H, Dichgans J, Naegele T (2004) Diffusion-weighted MRI of spinal cord infarction. High resolution and time course of diffusion abnormality. J Neurol 251:818–824
Larsen DW, Halbach VV, Teitelbaum GP, McDougall CG, Higashida RT, Dowd CF, Hieshima GB (1995) Spinal dural arteriovenous fistulas supplied by branches of the internal iliac arteries. Surg Neurol 43:35–40; discussion 40-1
Lasjaunias P, Berenstein A, ter Brugge KG (2001) Surgical Neuroangiography. Vol. 1. Clinical vascular anatomy and variations. Springer, Berlin
Mascalchi M, Cosottini M, Ferrito G, Salvi F, Nencini P, Quilici N (1998) Posterior spinal artery infarct. AJNR Am J Neuroradiol 19:361–363
Mawad ME, Rivera V, Crawford S, Ramirez A, and Breitbach W (1990) Spinal cord ischemia after resection of thoracoabdominal aortic aneurysms: MR findings in 24 patients. AJNR Am J Neuroradiol 11(5):987–991
Merland JJ, Riche MC, Chiras J (1980) Les fistules arterioveneuses intra-canalaires, extramedullaires à drainage veineux medullaire. J Neuroradiol 7:271–320
Merland JJ, Assouline E, Rüfenacht D, Guimaraens L, Laurent A (1986) Dural spinal arteriovenous fistulae draining into medullary veins: clinical and radiological results of treatment (embolisation and surgery) in 56 cases. Excerpta Med Int Congr Ser 698:283–289
Mikulis DJ, Ogilvy CS, McKee A, Davis KR, Ojeman RG (1992) Spinal cord infarction and fibrocartilagenous emboli. AJNR Am J Neuroradiol 13:155–160
Mull M (2002) Spinal Diseases. Vascular Diseases. In: Diagnostic and Interventional Neuroradiology. A Multimodality Approach. Hrsg. K. Sartor, Thieme, Stuttgart New York 310–315
Mull M (2005) Der akute Rückenmarkinfarkt: Diagnostik ohne therapeutischen Ansatz? Klinische Neuroradiologie 15:79–88.
Mull M, Thron A (1999) Spinale Durchblutungsstörungen. In: Neurologie in Klinik und Praxis. Hrsg: Hopf HC, Deuschl G, Diener HC, Reichmann R; Thieme, Stuttgart New York:402–408
Mull M, Thron A (2004) Imaging of Vscular Diseases of the Spinal Cord. Rivista di Neuroradiologia 17(3):351–359
Mull M, Thron A, Petersen D, Stoeter P (1992) Acute infarction of the spinal cord: clinical and neuroradiological findings in 20 patients. Neuroradiology 34:43
Mull M, Kosinski C, and Thron A (2002) Acute spinal cord ischemia-contribution of spinal angiography. J. Neuroradiol. 29:1–86
Naiman JL, Donohue WL, Prichards JS (1961) Fatal nucleus pulposus embolism of spinal cord after trauma. Neurology 11:83–87
Niimi Y, Berenstein A, Setton A, Neophytides A (1997) Embolization of spinal dural arteriovenous fistulae: results and follow-up. Neurosurgery 40:675–82; discussion 682-683
Partington MD, D.A. Rüfenacht, W.R. Marsch, D.G. Piepgras (1992) Cranial and sacral dural arteriovenous fistulas as a cause of myelopathy. J. Neurosurg. 76:615–622
Reinges MH, Thron A, Mull M, Huffmann BC, Gilsbach JM (2001) Dural arteriovenous fistulae at the foramen magnum. J Neurol 248:197–203
Rogopoulos A, Benchimol D, Paquis P, Mahagne MH, Bourgeon A (2000) Lumbar artery compression by the diaphragmatic crus: a new etiology for spinal cord ischemia. Ann Neurol 48:261–264
Rosenblum B, Oldfield EH, Doppman JL, Di Chiro G (1987) Spinal arteriovenous malformations: a comparison of dural arteriovenous fistulas and intradural AVM’s in 81 patients. J Neurosurg 67:795–802
Rosenkranz M, Grzyska U, Niesen W, Fuchs K, Schummer W, Weiller C, Röther J (2004) Anterior spinal artery syndrome following periradicular cervical nerve root therapy. J Neurol 251:229–231
Shigematsu Y, Korogi Y, Yoshizumi K, et al (2000) Three cases of spinal dural AVF: evaluation with first-pass, gadolinium-enhanced, three-dimensional MR angiography. J Magn Reson Imaging 12:949–952
Song JK, Vinuela F, Gobin YP, Duckwiler GR, Murayama Y, Kureshi I, Frazee JG, Martin NA (2001) Surgical and endovascular treatment of spinal dural arteriovenous fistulas: long-term disability assessment and prognostic factors. J Neurosurg 94:199–204
Spiller W (1909) Thrombosis of the cervical anterior median spinal artery. J Nerv Ment Dis 36:601
Stein SC, Ommaya AK, Doppman JL, Di Chiro G (1972) Arteriovenous malformation of the cauda equina with arterial supply from branches of the internal iliac arteries. Case report. J Neurosurg 36:649–651
Stepper F, Lövblad KO (2001) Anterior spinal artery stroke demonstrated by echo-planar DWI. Eur Radiol 11:2607–2610
Suh T.H., Alexander L (1939) Vascular system of the human spinal cord. Arch Neurol Psychiat 41:659–677
Suzuki T, Kawaguchi S, Takebayashi T, Yokogushi K, Takada J, Yamashita T (2003) Vertebral body ischemia in the posterior spinal artery syndrome: case report and review of the literature. Spine 28:E260–264
Symon L, Kuyama H, Kendall B (1984) Dural arteriovenous malformations of the spine. Clinical features and surgical results in 55 cases. J Neurosurg 60:238–247
Terwey B, Becker H, Thron AK, Vahldiek G (1989) Gadolinium-DTPA enhanced MR imaging of spinal dural arteriovenous fistulas. J Comput Assist Tomogr 13:30–37
Thron A (1988) Vascular anatomy of the spinal cord. Neuroradiological investigations and clinical syndromes. Springer, Wien New York
Thron A, Mull M (2004) Blood vessels of the Spinal Cord: Anatomical and MR-Imaging Correlation. Rivista di Neuroradiologia 17(3):277–281
Thron A, Koenig E, Pfeiffer P, Rossberg C (1987) Dural vascular anomalies of the spine-an important cause of progressive radiculomyelopathy. In: Cervos Navarro J, Ferszt R Stroke and microcirculation. Raven Press, New York:159–165
Thron A, Mull M, Reith W (2001) Spinale Gefäßmalformationen. Der Radiologe 41:949–954
Thron AK, Caplan L (2003) Vascular Malformations and Interventional Neuroradiology of the Spinal Cord. In: Neurological Disorders: Course and Treatment, Second Edition, Elsevier Science:517–528
Toro G, Roman GC, Navarro-Roman L, Cantillo J, Serrano B, Vergara I (1994) Natural history of spinal cord infarction caused by nucleus pulposus embolism. Spine 19:360–366
Tosi L, Rigoli G, Beltramello A (1996) Fibrocartilaginous embolism of the spinal cord: a clinical and pathogenetic reconsideration. J Neurol Neurosurg Psychiatry 60:55–60
Van Dijk JM, TerBrugge KG, Willinsky RA, Farb RI, and Wallace MC (2002) Multidisciplinary management of spinal dural arteriovenous fistulas: clinical presentation and long-term follow-up in 49 patients. Stroke 33(6):1578–1583
Weidauer S, Nichtweiss M, Lanfermann H, Zanella FE (2002) Spinal cord infarction: MR imaging and clinical features in 16 cases. Neuroradiology 44:851–857
Willinek WA, Gieseke J, Conrad R, Strunk H, Hoogeveen R, von Falkenhausen M, Keller E, Urbach H, Kuhl CK, Schild HH (2002) Randomly segmented central k-space ordering in high-spatial-resolution contrast-enhanced MR angiography of the supraaortic arteries: initial experience. Radiology 225:583–588
Yamada N, Okita Y, Minatoya K, Tagusari O, Ando M, Takamiya M, Kitamura S (2000a) Preoperative demonstration of the Adamkiewicz artery by magnetic resonance angiography in patients with descending or thoracoabdominal aortic aneurysms. Eur J Cardiothorac Surg 18:104–111
Yamada N, Takamiya M, Kuribayashi S, Okita Y, Minatoya K, Tanaka R (2000b) MRA of the Adamkiewicz artery: a preoperative study for thoracic aortic aneurysm. J Comput Assist Tomogr 24:362–368
Yuh WT, Marsh EE, Wang AK, Russell JW, Chiang F, Koci TM, Ryals TJ (1992) MR imaging of spinal cord and vertebral body infarction. AJNR Am J Neuroradiol 13:145–154
Zülch KJ (1954) Durchblutung an der Grenzzone zweier Gefäßgebiete als Urasche bisher ungeklärter Rückenmarksschädingungen. Deutsch ZNervenheilk. 172:81–101
Zülch KJ (1976) Pathogenetic and clinical observations in spinovascular insufficiency. Zentralbl Neurochir 37:1–13
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Mull, M., Thron, A. (2006). Spinal Infarcts. In: von Kummer, R., Back, T. (eds) Magnetic Resonance Imaging in Ischemic Stroke. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27738-2_17
Download citation
DOI: https://doi.org/10.1007/3-540-27738-2_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-00861-3
Online ISBN: 978-3-540-27738-5
eBook Packages: MedicineMedicine (R0)