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Microwave-assisted Heterocyclic Chemistry

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Microwave Methods in Organic Synthesis

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 266))

Abstract

Recent developments in the microwave-assisted synthesis of heterocycles are surveyed with the focus on diversity-oriented multi-component and multi-step one-pot procedures. Both solution- and solid-phase as well as polymer-supported methodologies for the preparation of libraries of heterocycles are reviewed. Advantages of microwave dielectric heating are highlighted by comparison with conventional thermal conditions.

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Abbreviations

BEMP:

2-tert-butylimino-2-dimethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine

DBU:

1,8-diazabicyclo[5.4.0]undec-7-ene

DHP:

dihydropyridine

DIEA:

diisopropylethylamine

DMAP:

4-(dimethylamino)pyridine

DMF:

N,N-dimethylformamide

DMF–DMA:

N,N-dimethylformamide dimethyl acetal

HBTU:

O-benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium hexafluorophosphate

HMDS:

hexamethyldisilazane

IL:

ionic liquids

MCR:

multi-component reaction

MW:

microwaves

NBS:

N-bromosuccinimide

NMP:

N-methyl-2-pyrrolidinone

PEG:

poly(ethylene glycol)

PPTS:

pyridinium p-toluenesulfonate

PS:

polymer supported

RCM:

ring-closing metathesis

SPE:

solid-phase extraction

SPOS:

solid-phase organic synthesis

TFA:

trifluoroacetic acid

THF:

tetrahydrofuran

TMS:

trimethylsilyl

Ts:

tosyl (p-toluenesulfonyl)

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Acknowledgments

We thank Professor E. Lukevics, Dr. J. Fotins and Dr. R. Zemribo for proof-reading of the manuscript and artist L. Putnina for designing the graphical abstract.

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  1. Latvian Institute of Organic Synthesis, Aizkraukles 21, 1006, Riga, Latvia

    Edgars Suna & Ilga Mutule

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  1. Edgars Suna
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Correspondence to Edgars Suna .

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Mats Larhed Kristofer Olofssonq

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Suna, E., Mutule, I. (2006). Microwave-assisted Heterocyclic Chemistry. In: Larhed, M., Olofssonq, K. (eds) Microwave Methods in Organic Synthesis. Topics in Current Chemistry, vol 266. Springer, Berlin, Heidelberg . https://doi.org/10.1007/128_058

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