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  • © 2022

Textbook of Allergen Tolerance

  • Includes all topics related to allergens, allergen responses, inflammation and allergen tolerance

  • Provides basic to cutting-edge developments to postgraduate students, clinical immunologists and allergy specialists

  • Includes pedagogical features as abstract, keywords, self-assessment, 20 audio files and videos to support readers

Buying options

Hardcover Book USD 139.99
Price excludes VAT (USA)
This title has not yet been released. You will be able to pre-order it soon.

About this book

Allergies are a significant health issue, yet few books exist on allergen tolerance of separation; here the author classifies allergen tolerance breakdown in specific types, according to the possibility that the autonomic breakdown of allergen tolerance in the unified airway depends on a deficit of pro-tolerogenic neurotransmitters at the local level. This paradigm, which explains the pathogenesis of allergic disorders, opens to new approaches to allergen-specific immunotherapy (AIT). While focusing on the new atopic disorders of the unified airway, such as local allergic rhinitis, "dual" allergic rhinitis, local allergic asthma, and local allergic conjunctivitis, the work combines clinical examples of allergic diseases and their treatment with their immunological background. 

The topics range from the specific immune-derived maintenance of allergen tolerance and the role of the neuroimmune network in allergic inflammation to conventional atopic diseases and more particular issues of local atopic disorders in the unified airway, oral tolerance, and its breakdown, and its translation in genitourinary aspects of allergic inflammation. Specific chapters are also devoted to allergen-specific immunotherapy (AIT) and anti-allergy treatments. Thought for upper graduate students, it will also be a valued resource for allergy practitioners, pulmonologists, ENT specialists, pediatricians, and translational researchers, Textbook of Allergen Tolerance includes classical didactic features such as abstracts, keywords, background notes, discussion points, and Q&A., as well as 20 audio files Text-to-Speech for the visually impaired, and 10 video to support the readers.



  • allergen tolerance breakdown
  • antigen
  • pro-tolerogenic cells
  • biomolecules
  • pro-tolerogenic neurotransmitters
  • unified airway disorders
  • atopic disorders
  • gastrointestinal tract
  • food allergies

Authors and Affiliations

  • Clinical Immunology and Allergy Department, Siberian State Medical University, Tomsk, Russia

    Vladimir V. Klimov

About the author

Vladimir Klimov graduated from Siberian State Medical University (SibSMU) in 1977; he then added to his training at the University of L'Aquila (Italy), where he specialized in allergy and clinical immunology (1996) and at Pittsburgh University School of Medicine, Department of Immunology and Center for Continuing Education, USA (2005). Currently, he holds PhD, DSc, MD degrees, and he is the Head of SibSMU Clinical Immunology & Allergy Dept and Immunologist-in-Chief of Tomsk Region, in Russia. Prof. Klimov has over 30 years of experience in routine work in both immunology and paediatrics, and 20 years of experience in Immunology e-Teaching to international students. Skilled in pedagogical, clinical and computer work, he lectures to students including international students, consults patients, and implements scientific research.

Bibliographic Information

  • Book Title: Textbook of Allergen Tolerance

  • Authors: Vladimir V. Klimov

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022

  • Edition Number: 1

  • Number of Pages: XXV, 301

  • Number of Illustrations: 21 b/w illustrations, 71 illustrations in colour

  • Topics: Allergology, Immunology

Buying options

Hardcover Book USD 139.99
Price excludes VAT (USA)
This title has not yet been released. You will be able to pre-order it soon.