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  • Book
  • © 2023


Methods and Protocols

  • Includes cutting-edge techniques

  • Provides step-by-step detail essential for reproducible results

  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2600)

Buying options

Hardcover Book USD 249.99
Price excludes VAT (USA)
This title has not yet been released. You will be able to pre-order it soon.

About this book

This detailed book collects methodologies exploring mechanobiology, the involvement of mechanical forces in cell fate specification and in controlling single and collective cell behaviors such as directed migration, morphogenesis, wound healing, and the immune response. The volume features methods to quantify the mechanical properties of cells and adhesion proteins, to expose cells to external mechanical forces, to quantitatively characterize mechano-responses at various scales, to measure forces applied by cells on the extracellular matrix, as well as chapters on force measurement inside cells, probing cell signaling and gene expression in response to force, and biophysical modeling of cell shape and protein dynamics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary material and reagents, step-by-step and readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Mechanobiology: Methods and Protocols aims to provide meaningful tools for cell and developmental biologists approaching the study of cell and tissue dynamics from a mechanobiological perspective, molecular biologists interested in the effects of force on proteins, as well as for cancer biologists and biophysicists.


  • Mechanotransduction
  • Gene expression
  • Mechanosensing
  • Cellular forces
  • Mechanical cues
  • Biophysical models

Editors and Affiliations

  • Department of Cell and Developmental Biology, Tel Aviv University, Tel Aviv, Israel

    Ronen Zaidel-Bar

Bibliographic Information

  • Book Title: Mechanobiology

  • Book Subtitle: Methods and Protocols

  • Editors: Ronen Zaidel-Bar

  • Series Title: Methods in Molecular Biology

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2023

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: VIII, 317

  • Number of Illustrations: 8 b/w illustrations, 96 illustrations in colour

  • Topics: Mechanobiological Cell Signaling, Molecular Biophysics, Cell Biology

Buying options

Hardcover Book USD 249.99
Price excludes VAT (USA)
This title has not yet been released. You will be able to pre-order it soon.