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HDAC/HAT Function Assessment and Inhibitor Development

Methods and Protocols

  • Includes cutting-edge techniques

  • Provides step-by-step detail essential for reproducible results

  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2589)

Buying options

Hardcover Book USD 299.99
Price excludes VAT (USA)
This title has not yet been released. You will be able to pre-order it soon.

About this book

This fully updated edition provides a series of methods for how best to assess functions of histone deacetylases and acetyltransferases. The disease-relevance of dysregulated protein deacetylation by overexpressed or aberrantly activated histone deacetylases has spurred an intense search for novel and improved inhibitors of these enzymes, as reflected in this collection. Expert contributors explore the generation and evaluation of novel histone deacetylase inhibitors and new and improved techniques to assess acetylation-dependent molecular mechanisms in vitro and in vivo. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and up-to-date, HDAC/HAT Function Assessment and Inhibitor Development: Methods and Protocols, Second Edition serves as an ideal guide for researchers seeking to further elucidate this vital area of study.

Keywords

  • Histone deacetylases
  • Histone acetyltransferases
  • Protein acetylation and deacetylation
  • Dysregulated protein
  • Enzyme inhibitors
  • HDACi
  • Chromatin

Editors and Affiliations

  • Institute of Toxicology, University Medical Center Mainz, Mainz, Germany

    Oliver H. Krämer

Bibliographic Information

  • Book Title: HDAC/HAT Function Assessment and Inhibitor Development

  • Book Subtitle: Methods and Protocols

  • Editors: Oliver H. Krämer

  • Series Title: Methods in Molecular Biology

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2023

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 2

  • Number of Pages: XVII, 511

  • Number of Illustrations: 39 b/w illustrations, 98 illustrations in colour

  • Topics: Protein Biochemistry, Enzymology

Buying options

Hardcover Book USD 299.99
Price excludes VAT (USA)
This title has not yet been released. You will be able to pre-order it soon.