Overview
- Editors:
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Inka Brockhausen
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Department of Medicine, Queen’s University, Kingston, Canada
Department of Biochemistry, Queen’s University, Kingston, Canada
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Table of contents (24 protocols)
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Front Matter
Pages i-xviii
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- Jeffrey S. Rush, Charles J. Waechter
Pages 13-30
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- Tamao Endo, Hiroshi Manya
Pages 43-56
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- Aleksandra Nita-Lazar, Robert S. Haltiwanger
Pages 57-68
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- Johannis P. Kamerling, Gerrit J. Gerwig
Pages 69-91
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- Silke Schrader, Roland Schauer
Pages 93-107
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- Catherine Robbe, Jean-Claude Michalski, Calliope Capon
Pages 109-123
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- Louise Royle, Catherine M. Radcliffe, Raymond A. Dwek, Pauline M. Rudd
Pages 125-143
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- Anne Imberty, Michaela Wimmerová, Jaroslav Koča, Christelle Breton
Pages 145-156
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- Fabio Dall’Olio, Nadia Malagolini, Mariella Chiricolo
Pages 157-170
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- Maëlle Prorok-Hamon, Sylvie Mathieu, Assou El-Battari
Pages 171-186
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- Juan J. García-Vallejo, Sonja I. Gringhuis, Willem van Dijk, Irma van Die
Pages 187-209
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- Inka Brockhausen, Xiaojing Yang, Mark Harrison
Pages 211-236
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- Cristina L. Marolda, Piya Lahiry, Enrique Vinés, Soledad Saldías, Miguel A. Valvano
Pages 237-252
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- Inka Brockhausen, Walter A. Szarek, John G. Riley, Jason Z. Vlahakis
Pages 253-265
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- Karen J. Rees-Milton, Tassos P. Anastassiades
Pages 267-275
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- Pablo Argüeso, Ilene K. Gipson
Pages 277-288
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About this book
Glycobiology involves studies of complex carbohydrates and posttrans- tional modifications of proteins, and has become an important interdiscip- nary field encompassing chemistry, biochemistry, biology, physiology, and pathology. Although initial research was directed toward elucidation of the different carbohydrate structures and the enzymes synthesizing them, the field has now moved toward identifying the functions of carbohydrates. The pro- cols described in Glycobiology Protocols form a solid basis for investigations of glycan functions in health and disease. The cloning of many of the genes participating in glycosylation processes has helped to enhance our knowledge of how glycosylation is controlled, but has also added another dimension of complexity to the great heterogeneous variety of the structures of the oligos- charides of glycoproteins, proteoglycans, and glycolipids. A family of similar enzyme proteins exists for each glycosylation step. Glycosyltransferases are extremely specific for both the nucleotide sugar donor and the acceptor s- strate, but many other factors control sugar transfer, including the locali- tion and topology of enzymes, cofactors, possible chaperone proteins, and the availability of sugar acceptor substrates. The analysis of the intracellular organization of glycosylation and of the factors controlling the activities of the participating enzymes in the cell are important areas that need more research efforts. Another challenge for future research is to understand the glycodynamics of a cell, that is, how the cell responds to stimuli leading to biological and pathological changes in terms of alterations in glycosylation, and how this affects the biology of the cell.
Reviews
"...a very valuable handbook for a wide audience of specialists involved in studies of carbohydrates and carbohydrate-containing biopolymers; glycobiologists, biochemists, bioorganic chemists, and molecular and cell biologists." -Biochemistry
Editors and Affiliations
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Department of Medicine, Queen’s University, Kingston, Canada
Inka Brockhausen
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Department of Biochemistry, Queen’s University, Kingston, Canada
Inka Brockhausen
