Bioinformatics and Drug Discovery

  • Richard S. Larson

Part of the Methods in Molecular Biology book series (MIMB, volume 316)

Table of contents

  1. Front Matter
    Pages i-x
  2. Eliot H. Ohlstein, Anthony G. Johnson, John D. Elliott, Anne M. Romanic
    Pages 1-11
  3. Scott A. Ness
    Pages 13-33
  4. Xiwei Wu, T. Gregory Dewey
    Pages 35-48
  5. Francisco Azuaje, Fatima Al-Shahrour, Joaquin Dopazo
    Pages 67-86
  6. James O. McInerney, Caroline S. Finnerty, Jennifer M. Commins, Gayle K. Philip
    Pages 87-109
  7. Casey S. Husser, Jeffrey R. Buchhalter, O. Scott Raffo, Amnon Shabo, Steven H. Brown, Karen E. et al.
    Pages 111-157
  8. Suma Kaveti, John R. Engen
    Pages 179-197
  9. Laurel O. Sillerud, Richard S. Larson
    Pages 227-289
  10. Darren R. Flower
    Pages 291-358
  11. Bassil I. Dahiyat
    Pages 359-374
  12. Cristian G. Bologa, Marius M. Olah, Tudor I. Oprea
    Pages 375-388
  13. Alexis S. Ivanov, Alexander V. Veselovsky, Alexander V. Dubanov, Vladlen S. Skvortsov
    Pages 389-431
  14. Back Matter
    Pages 433-444

About this book

Introduction

Many of the new technologies that are transforming drug discovery require a high degree of interdisciplinary expertise in physical science, life science, and computer science for bioinformatic analysis of their output. In Bioinformatics and Drug Discovery, a panel of researchers from academic and pharmaceutical laboratories describes readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described. The protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and highly practical, Bioinformatics and Drug Discovery makes it possible to apply in the research laboratory the powerful new technologies that promise to greatly improve and speed up the discovery of new drugs.

Keywords

In silico Radiologieinformationssystem bioinformatics development drug drug discovery evolution gene expression genes genome genomics informatics microarray protein standardization

Editors and affiliations

  • Richard S. Larson
    • 1
  1. 1.Department of PathologyUniversity of New Mexico School of MedicineAlbuquerque

Bibliographic information

  • DOI https://doi.org/10.1385/1592599648
  • Copyright Information Humana Press 2006
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-346-6
  • Online ISBN 978-1-59259-964-6
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • About this book