Drug Interactions in Infectious Diseases

1. Front Matter

   Pages i-x

   PDF

2. Introduction to Drug Interactions

   • Keith Gallicano, George Drusano

   Pages 1-11

3. Mechanisms of Drug Interactions I

   • Angela D. M. Kashuba, Joseph S. Bertino Jr

   Pages 13-39

4. Mechanisms of Drug Interactions II

   • Scott R. Penzak

   Pages 41-82

5. Drug Interactions

   • Kellie Schoolar Reynolds

   Pages 83-99

6. Drug Interactions With Antiretrovirals for HIV Infection

   • Kimberly A. Struble, Stephen C. Piscitelli

   Pages 101-136

7. Drugs for HIV-Related Opportunistic Infections

   • Alice Tseng

   Pages 137-189

8. Drugs for Tuberculosis

   • Rocsanna Namdar, Steven C. Ebert, Charles A. Peloquin

   Pages 191-213

9. Quinolones

   • David R. P. Guay

   Pages 215-254

10. β-Lactam Antibiotics

    • Melinda M. Neuhauser, Larry H. Danziger

    Pages 255-287

11. Antifungal Agents

    • Paul O. Gubbins, Scott A. McConnell, Jarrett R. Amsden

    Pages 289-337

12. Miscellaneous Antibiotics

    • Gregory M. Susla

    Pages 339-381

13. Drug-Food Interactions

    • Kelly A. Harris, Kevin W. Garey, Keith A. Rodvold

    Pages 383-430

14. Drug-Cytokine Interactions

    • Curtis E. Haas, Jamie L. Nelsen

    Pages 431-461

15. Circumventing Drug Interactions

    • Douglas N. Fish

    Pages 463-481

16. Design and Data Analysis of Drug Interaction Studies

    • David E. Nix, Keith Gallicano

    Pages 483-505

17. Back Matter

    Pages 507-534

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Over the past 25 years, the world’s population has witnessed an explosion in kno- edge about infectious diseases. The global population is coming to the realization that diseases long recognized to cause substantial suffering, such as malaria, tuberculosis, schistosomiasis, and hepatitis, can be diagnosed and treated, and that transmission can be prevented using tools that are available, and which may be becoming increasingly affordable. The global population is recognizing that few infections are local: the travel of humans, other animals, insects, and food transport pathogens around the world, often with astonishing rapidity. New pathogens are appearing, either newly recognized or newly developing, such as severe acute respiratory syndrome (SARS), avian inf- enza, metapneumovirus, or hepatitis C, which are causing human morbidity and m- tality. Finally, there is growing fear that dangerous pathogens may be intentionally introduced into human populations by deranged individuals or terrorist organizations. The potential to use drugs or biologic agents to treat and prevent infectious diseases has increased dramatically over the past quarter century as we have learned more about the biology of many of these agents, and as we have developed techniques to discover new agents by high throughput screening programs and by sophisticated drug design and synthesis.

• HIV
• HIV infection
• Malaria
• antibiotics
• infection
• infections
• infectious
• infectious disease
• infectious diseases

From Reviews of the First Edition...

"...an invaluable reference source for health practitioners working in the field of infectious diseases..." -Journal of Antimicrobial Chemotherapy

"...an interesting and extensively referenced book that should prove extremely helpful to pharmacists, pharmacologists, and medical educators...can also benefit ID clinicians, as a useful reference and a review of the mechanisms of drug interactions."
-Clinical Infectious Diseases

"....a useful and impressive book...an essential reference source."
-British Journal of Clinical Pharmacology

"...recommend[ed] to anyone involved in the management of infectious disease."
-Transactions of the Royal Society of Tropical Medicine

"...highly recommended for all medical collections."
-E-Streams

"...a valuable text for all practitioners involved in using anti-infective agents...provide[s] insight into the very important issue of drug interactions."
-Doody's Health Sciences Book Review Journal

"...excellently presented and readable." -BTS Newsletter

"...superior." -BTS Newsletter

• Discovery Medicine-Antivirals, GlaxoSmithKline, Research Triangle Park

  Stephen C. Piscitelli

• College of Pharmacy and Medicine, University of Illinois at Chicago, Chicago

  Keith A. Rodvold

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