Cardiovascular Genomics

  • Mohan K. Rai
  • Julian F. R. Paton
  • Sergey Kasparov
  • Michael J. Katovich

Part of the Contemporary Cardiology book series (CONCARD)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Genes and Polymorphisms in Cardiovascular Disease

    1. Front Matter
      Pages 1-1
    2. Bina Joe, Michael R. Garrett
      Pages 41-58
    3. Kamal Rahmouni, Curt D. Sigmund
      Pages 59-70
    4. Julie A. Johnson, Larisa H. Cavallari
      Pages 71-93
    5. Anke-Hilse Maitland-van der Zee, Olaf H. Klungel, Anthonius de Boer
      Pages 95-114
    6. Hideko Kasahara
      Pages 115-134
  3. Gene Transfer for Combating Cardiovascular Disease

    1. Front Matter
      Pages 135-135
    2. Ryuichi Morishita
      Pages 137-156
    3. Alok S. Pachori, Luis G. Melo, Victor J. Dzau
      Pages 157-173
    4. William H. Miller, Stuart A. Nicklin, Andrew H. Baker, Anna F. Dominiczak
      Pages 175-196
    5. Michael J. Katovich, Justin L. Grobe, Mohan K. Raizada
      Pages 213-246
    6. Sergey Kasparov, A. G. Teschemacher, Julian F. R. Paton
      Pages 247-268
    7. M. Ian Phillips, Yi Tang
      Pages 269-283
    8. Yoshimasa Watanabe, Donald D. Heistad
      Pages 285-302
  4. Regenerative Tissues for the Diseased Cardiovascular System

    1. Front Matter
      Pages 303-303

About this book

Introduction

After more than 50 years of limited success in controlling blood pressure with traditional antihypertensive drugs, the time is ripe to explore alternate strategies for managing cardiovascular diseases. In Cardiovascular Genomics, recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. They involve genetic linkage analysis and substitution mapping using congenic strains, microarray techniques, and strategies for discovery in animal models of hypertension. The new transgenic mouse models that either over- or underexpress angiotensinogen are used to illuminate the function of the tissue renin-angiotensin systems, enhancing the understanding of the role of polymorphisms, a crucial factor for effective design of new drugs. The chapters on gene transfer and gene therapy cover a wide variety of topics ranging from novel clinical applications for treating stroke, coronary, and peripheral vascular diseases, to producing new cardiovascular cells and tissues, to using viral vectors as tools. A value-added compact disk containing a companion ebook version of Cardiovascular Genomics is included for downloading and use in the reader's PC or PDA.
Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both cutting-edge scientific approaches through the new science of cardiovascular genomics, and the efficacious results it is now possible to obtain.

Keywords

Angiotensin II cardiovascular gene therapy genes hypertension

Editors and affiliations

  • Mohan K. Rai
    • 1
  • Julian F. R. Paton
    • 2
  • Sergey Kasparov
    • 2
  • Michael J. Katovich
    • 3
  1. 1.Department of Physiology and Functional GenomicsUniversity of Florida College of MedicineGainesville
  2. 2.Department of Physiology, School of Medical SciencesUniversity of BristolBristol
  3. 3.Department of PharmacodynamicsUniversity of Florida College of PharmacyGainesville

Bibliographic information

  • DOI https://doi.org/10.1385/1592598838
  • Copyright Information Humana Press Inc. 2005
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-58829-400-5
  • Online ISBN 978-1-59259-883-0
  • About this book