Overview
- Editors:
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Z. David Luo
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Department of Anesthesiology, University of California Irvine Medical Center, Irvine
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Table of contents (21 protocols)
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- Jeffrey W. Allen, Tony L. Yaksh
Pages 11-23
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- Jeffrey W. Allen, Tony L. Yaksh
Pages 25-34
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- Jin Mo Chung, Hee Kee Kim, Kyungsoon Chung
Pages 35-45
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- Thies Lindenlaub, Claudia Sommer
Pages 47-53
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- Erin D. Milligan, Steven F. Maier, Linda R. Watkins
Pages 67-89
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- Emiliano S. Higuera, Z. David Luo
Pages 91-98
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- Shelle A. Malkmus, Tony L. Yaksh
Pages 109-121
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- Koichi Iwata, Yuji Masuda, Ke Ren
Pages 123-137
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- Louise C. Stanfa, Anthony H. Dickenson
Pages 139-153
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- Maria Schäfers, David Cain
Pages 155-166
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- Luc Jasmin, Peter T. Ohara
Pages 167-188
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- Thomas H. Burkey, Cynthia M. Hingtgen, Michael R. Vasko
Pages 189-202
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- Virginia S. Seybold, Lia G. Abrahams
Pages 203-213
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- Fredrik Kamme, Jessica Zhu, Lin Luo, Jingxue Yu, Da-Thao Tran, Bernhard Meurers et al.
Pages 215-223
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- Hong Qing Guo, Sandra R. Chaplan
Pages 225-238
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- Stephen J. Walker, Travis J. Worst, Willard M. Freeman, Kent E. Vrana
Pages 239-253
About this book
The detrimental impacts of pain on the quality of our daily life have drawn increasing attention from researchers, health care providers, policymakers, and social workers. The reality of effective painkillers specifically designed for different types of pain states has been obscured by missing knowledge of the mechanisms of different types of pain. Thus, studying the complexity of pain transduction, which includes various insults to the peripheral nervous systems, sensitized spinal circuits, and altered signals ascending to or descending from the brain, has emerged as a high priority task on the agenda of pharmaceutical companies and other private as well as public agencies. To accomplish this mission, one requires a combination of well-integrated systems, such as a- mal models resembling the pathological conditions of pain transduction, and an understanding of the interactions among pain transducers and mediators at the molecular level. Thanks to rapid advancements in the developmentof novel cellular and molecular biology techniques, as well as in our understanding of physiology, and of the behavioral pharmacology of pain transduction, the time is now ripe for dissecting the molecular mechanisms of pain transduction using multidisciplinary approaches. Indeed, my acceptance of the invitation from the series editor, Dr. John Walker, to assemble a book of methods and protocols for pain research was inspired by these emerging needs. The purpose of Pain Research: Methods and Protocols is to provide st- by-step methods and protocols of multidisciplinary approaches related to the study of pain transduction.
Editors and Affiliations
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Department of Anesthesiology, University of California Irvine Medical Center, Irvine
Z. David Luo
