In Vitro Neurotoxicology

Principles and Challenges

  • Evelyn Tiffany-Castiglioni
  • Mannfred A. Hollinger

Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Evelyn Tiffany-Castiglioni
    Pages 1-28
  3. William H. Hanneman, Melvin E. Andersen, Marie E. Legare, Christine T. French, Tami S. McMullin, Carolyn Broccardo et al.
    Pages 41-57
  4. Gerald J. Audesirk, Ronald B. Tjalkens
    Pages 59-93
  5. Lori D. White, Sid Hunter, Michael W. Miller, Marion Ehrich, Stanley Barone Jr.
    Pages 95-132
  6. Michael Aschner, Ursula Sonnewald
    Pages 133-150
  7. Evelyn Tiffany-Castiglioni, Yongchang Qian
    Pages 151-186
  8. Stanley Barone Jr., Prasada R. S. Kodavanti, William R. Mundy
    Pages 187-215
  9. Stephen M. Lasley, Mary E. Gilbert
    Pages 217-241
  10. Marie-Gabrielle Zurich, Florianne Monnet-Tschudi, Lucio G. Costa, Benoît Schilter, Paul Honegger
    Pages 243-266
  11. W. Les Dees, Jill K. Hiney, Robert K. Dearth, Vinod K. Srivastava
    Pages 267-289
  12. Back Matter
    Pages 315-331

About this book


Neurotoxicity assessment with in vitro systems offers not only a means to better understand mechanisms of action of toxicants and decrease reliance on laboratory animals, but also provides a basis for reliable, high throughput screening of new and untested chemicals. In In Vitro Neurotoxicology: Principles and Challenges, well-respected leaders in the field take a fresh look at their own and others' work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. In thematically organized chapters, the authors employ examples comprised of multiple experimental systems and endpoints, and discuss the use of complementary in vivo/in vitro strategies. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well studied both in vivo and in vitro: lead, mercury, organophosphorus insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. Several neurotoxicology topics covered provide insight into neurodevelopmental and neurodegenerative diseases, including the concept of astroglia as depots for lead and other metals in the central nervous system, the elucidation of factors involved in the onset of puberty in females, and the exploration of endogenous proteins as neurotoxicants.
Authoritative and forward-looking, In Vitro Neurotoxicology: Principles and Challenges sets out new concepts and research directions that will facilitate significant improvement in today's methods and systems for in vitro neurotoxicity testing.

Editors and affiliations

  • Evelyn Tiffany-Castiglioni
    • 1
    • 2
  • Mannfred A. Hollinger
    • 3
  1. 1.Department of Veterinary Anatomy and Public HealthTexas A&M University College of Veterinary MedicineCollege Station
  2. 2.Center for Environmental and Rural HealthCollege Station
  3. 3.University of CaliforniaDavis

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2004
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-047-2
  • Online ISBN 978-1-59259-651-5
  • Series Print ISSN 1557-2153
  • Series Online ISSN 1940-6053
  • Buy this book on publisher's site