The Blood-Brain Barrier

Biology and Research Protocols

  • Sukriti Nag
Part of the Methods in Molecular Medicine™ book series (MIMM, volume 89)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Tissue Techniques

  3. Blood-Brain Barrier Permeability Techniques

  4. Blood-Brain Barrier Transport Techniques

    1. Front Matter
      Pages 191-191
    2. Quentin R. Smith, David D. Allen
      Pages 209-218
    3. Hiroyuki Kusuhara, Tetsuya Terasaki, Yuichi Sugiyama
      Pages 219-231
    4. Darryl R. Peterson, Richard A. Hawkins
      Pages 233-247
    5. Haiqing Dai, William F. Elmquist
      Pages 249-264

About this book

Introduction

Despite the fact that the breakdown of the blood-brain barrier occurs in many brain diseases and is an important factor in mortality, the molecular mechanisms involved in the breakdown are not completely understood. In The Blood-Brain Barrier: Biology and Research Protocols, leading researchers and clinician-scientists present state-of-the-art morphologic, permeability, transport, in vitro, and molecular techniques to study the workings of the blood-brain barrier in health and disease. Described in step-by-step detail, each proven method includes an explanation of the theoretical basis of the method, a discussion of its advantages and limitations, notes on avoiding pitfalls, and examples of results obtained using the technique. At the cutting edge are techniques to explore the genomics and proteomics of brain endothelium.
Comprehensive and state-of-the-art, The Blood-Brain Barrier: Biology and Research Protocols offers pharmacologists, physiologists, neuroscientists, neurosurgeons, and neurologists an array of powerful tools to isolate undiscovered molecules, deepen our understanding of their role in health and disease, and identify targets for future gene therapy and therapeutic intervention.

Editors and affiliations

  • Sukriti Nag
    • 1
    • 2
  1. 1.Division of NeuropathologyUniversity of TorontoTorontoCanada
  2. 2.Toronto Western Research Institute and Department of PathologyUniversity Health NetworkTorontoCanada

Bibliographic information

  • DOI https://doi.org/10.1385/1592594190
  • Copyright Information Humana Press 2003
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-073-1
  • Online ISBN 978-1-59259-419-1
  • Series Print ISSN 1543-1894
  • Series Online ISSN 1940-6037
  • About this book