Tumor Suppressor Genes

1. Front Matter

   Pages i-xix

   PDF

2. Known Tumor Suppessor Genes and Pathways

   1. Front Matter

      Pages 1-1

      PDF

   2. Growth Control by the Retinoblastoma Gene Family

      • Marco G. Paggi, Armando Felsani, Antonio Giordano

      Pages 3-19

   3. The APC Tumor Suppressor Pathway

      • Patrice J. Morin, Ashani T. Weeraratna

      Pages 21-40

   4. Hereditary Breast and Ovarian Cancer Genes

      • Ralph Scully, Nadine Puget

      Pages 41-57

   5. Hereditary Colon Cancer Genes

      • William M. Grady, Sanford D. Markowitz

      Pages 59-83

   6. Patched, Hedgehog, and Skin Cancer

      • Anthony G. Quinn, Ervin Epstein Jr.

      Pages 85-95

   7. Tumor Suppressor Genes in Lung Cancer

      • Arvind K. Virmani, Adi F. Gazdar

      Pages 97-115

   8. TP53, hChk2, and the Li-Fraumeni Syndrome

      • Jenny Varley

      Pages 117-129

   9. Genetic Alterations in Esophageal Cancer

      • Jun-ichi Okano, Lorraine Snyder, Anil K. Rustgi

      Pages 131-145

   10. PTEN and Cancer

       • Ramon Parsons, Laura Simpson

       Pages 147-166

   11. VHL and Kidney Cancer

       • Michael Ohh, William G. Kaelin Jr.

       Pages 167-183

   12. p16INK4A and Familial Melanoma

       • Kapaettu Satyamoorthy, Meenhard Herlyn

       Pages 185-195

   13. The INK4a/ARF Locus and Human Cancer

       • Greg H. Enders

       Pages 197-209

   14. Progression Model of Prostate Cancer

       • Teresa Acosta Almeida, Nickolas Papadopoulos

       Pages 211-222

   15. Neurofibromatosis Type 1

       • Margaret E. McLaughlin, Tyler Jacks

       Pages 223-237

   16. Wilms’ Tumor as a Model for Cancer Biology

       • Andrew P. Feinberg, Bryan R. G. Williams

       Pages 239-248

   17. Inadequate “Caretaker” Gene Function and Human Cancer Development

       • Theodore L. DeWeese, William G. Nelson

       Pages 249-268

   18. The Regulation of Tumor Suppressor Genes by Oncogenes

       • Paul Dent, Liang Qiao, Donna Gilfor, Michael Birrer, Steven Grant, Paul B. Fisher

       Pages 269-292

3. Identification of Tumor Suppressor Genes

   1. Front Matter

      Pages 293-293

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It has become clear that tumors arise from excessive cell proliferation and a c- responding reduction in cell death. Tumors result from the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emphasis shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and tumor suppressor genes function in the same pathways, providing positive and ne- tive growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Tumor suppressor genes are mutated in hereditary cancer syndromes, as well as somatically in nonhereditary cancers. In their normal state, TSGs control cancer development and p- gression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pathways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access the powerful tools now available to discover these genes, as well as their links to cell biology and growth control.

• Colon
• angiogenesis
• cell biology
• gene expression
• influence
• proteins
• regulation

• Departments of Medicine, Genetics, and Pharmacology, University of Pennsylvania School of Medicine, Philadelphia

  Wafik S. El-Deiry

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