Overview
- Editors:
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Amanda E. I. Proudfoot
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Serono Pharmaceutical Research Institute, Geneva, Switzerland
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Timothy N. C. Wells
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Serono Pharmaceutical Research Institute, Geneva, Switzerland
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Christine A. Power
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Serono Pharmaceutical Research Institute, Geneva, Switzerland
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Table of contents (36 protocols)
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- Arlene J. Hoogewerf, Gabriele S. V. Kuschert
Pages 173-177
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- Gerard J. Graham, Mary G. Freshney
Pages 179-189
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- Matthias Mack, Detlef Schlöndorff
Pages 191-195
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- Nathalie Signoret, Mark Marsh
Pages 197-207
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- Jacqueline D. Reeves, Graham Simmons
Pages 209-222
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- Paul D. Ponath, Nasim Kassam, Shixin Qin
Pages 231-242
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- Iqbal Grewal, Long Gu, Susan Tseng, Barrett J. Rollins
Pages 243-251
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- Ji-Liang Gao, Philip M. Murphy
Pages 259-274
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- Maria-Jesus Sanz, Peter J. Jose, Timothy J. Williams
Pages 275-283
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- Sami Alouani, Pierre Juillard, Yolande Chvatchko
Pages 285-293
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- Emma M. Campbell, Nicholas W. Lukacs
Pages 295-302
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- Andrew S. McWilliam, Patrick G. Holt
Pages 303-309
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- Clare Lloyd, Jose-Carlos Gutierrez-Ramos
Pages 311-318
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- Charles W. Frevert, Gustavo Matute-Bello, Thomas R. Martin
Pages 319-330
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Back Matter
Pages 331-353
About this book
The chemokines family of small proteins are involved in numerous b- logical processes ranging from hematopoiesis, angiogenesis, and basal l- kocyte trafficking to the extravasation and tissue infiltration of leukocytes in response to inflammatory agents, tissue damage, and bacterial or viral infection. Chemokines exert their effects through a family of seven G-protein coupled transmembrane receptors. Worldwide interest in the chemokine field surged dramatically early in 1996, with the finding that certain chemokine receptors were the elusive coreceptors, required along with CD4, for HIV infection. Today, though over 40 human chemokines have been described, the n- ber of chemokine receptors lags behind—only 17 human chemokine receptors have been identified so far. What has emerged over the years is that most chemokine receptors bind several distinct ligands, and indeed the majority of chemokines are able to bind to multiple chemokine receptors, explaining to some extent the apparent disparity in the numbers of chemokines and rec- tors. Yet in spite of the apparent redundancy in chemokine/chemokine rec- tor interactions, it is clear that in vivo, spatial, temporal, and indeed cell- and tissue-specific expression of both chemokines and their receptors are imp- tant factors in determining the precise nature of cellular infiltrates in phy- ological and pathological processes.
Reviews
highly recommended...Seldom does on find so much valuable information, concisely presented and with such obvious potential for the future, made available in one volume." - E-Streams
"...Chemokine Protocols is a collection of clear, well written protocols and I would recommend it as an excellent starting point for any scientist with an interest in chemokines." - Molecular Biotechnology