Overview
- Editors:
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Judes Poirier
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Douglas Hospital Research Centre, Verdun, Canada
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Table of contents (14 protocols)
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- Isabelle Martinou, Harald Frankowski, Marc Missotten, Remy Sadoul, Jean-Claude Martinou
Pages 1-11
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- Martin Gschwind, Gerda Huber
Pages 13-31
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- Thomas Mahalik, Malcolm Wood, Gregory Owens
Pages 33-46
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- Guang-Mei Yan, Steven M. Paul
Pages 47-66
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- Shahin Sakhi, Steven S. Schreiber
Pages 85-98
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- Emmanuel Moyse, Denis Michel
Pages 133-159
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- Patricia Boksa, Uwe Beffert, Doris Dea, Richard Alonso, Dayan O’Donnell, Judes Poirier
Pages 161-182
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- Frank M. LaFerla, Gilbert Jay
Pages 183-195
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- Lisa Ayn Kerrigan, Donald J. Zack
Pages 197-215
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- Kathrin D. Geiger, Floyd E. Bloom, Nora E. Sarvetnick
Pages 217-235
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- Emanuela Bonfoco, Maria Ankarcrona, Dimitri Krainc, Pierluigi Nicotera, Stuart A. Lipton
Pages 237-253
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- Paul Desjardins, Stephane Ledoux
Pages 255-277
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Back Matter
Pages 279-286
About this book
After many years of neglect, the study of normal cell death and the so-called programmed cell death has finally gained some needed momentum. Evidence obtained over the last five years indicates that programmed cell death (also referred to as apop tosis) occurs normally in most animal tissues at some we- defined stages of their development and/or maturation. The molecular mechanisms by which it is executed remains - known. However, key regulatory and metabolic steps have been identified in the apoptotic cascade and a central concept has progressively emerged: Apoptosis appears to occur by default in many different cell types unless suppressed by signals ori- nating from neighboring cells. As Martin Raff noted a few years ago, this molecular cascade probably imposes a form of social control on cell survival and cell death. Since our understanding of the apoptosis phenomena has grown significantly over the last few years, we have been - powered by recent technological advances to biochemically d- sect the key metabolic components of apoptotic and necrotic cascades in normal and injured brains. Moreover, the devel- ment of improved histochemical tools has allowed us to better define the fundamental criteria of cell death, and transgenic te- nology has allowed scientists to test working hypotheses p- taining to the mechanism of action of the so-called “cell death gene.
Reviews
The book is useful for an actively working neuroscientist who is going to study apotosis and has enough experience to choose the most suitable models and protocols among all the diverse offerings of the book. Three Stars. -Doody's Health Sciences Book Review Journal
Editors and Affiliations
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Douglas Hospital Research Centre, Verdun, Canada
Judes Poirier