Drug-DNA Interaction Protocols

  • Keith R. Fox

Part of the Methods in Molecular Biology™ book series (MIMB, volume 90)

Table of contents

  1. Front Matter
    Pages i-x
  2. Keith R. Fox
    Pages 1-22
  3. James C. Dabrowiak, Jerry Goodisman, Brian Ward
    Pages 23-42
  4. Niels Erik Møllegaard, Peter E. Nielsen
    Pages 43-49
  5. Philip M. Brown, Keith R. Fox
    Pages 81-93
  6. Suzanne M. Cutts, Andrew Masta, Con Panousis, Peter G. Parsons, Richard A. Sturm, Don R. Phillips
    Pages 95-106
  7. Suzanne M. Cutts, Con Panousis, Andrew Masta, Don R. Phillips
    Pages 107-115
  8. Thomas P. Dooley, Katherine L. Weiland
    Pages 117-125
  9. Don R. Phillips, Carleen Cullinane
    Pages 127-145
  10. Jeremy S. Lee, Laura J. P. Latimer, Jamshid Tanha
    Pages 181-188
  11. Jeremy S. Lee, Laura J. P. Latimer, Gary D. Burkholder
    Pages 189-193
  12. W. David Wilson, Farial A. Tanious, Maria Fernandez-Saiz, C. Ted Rigl
    Pages 219-240
  13. Dietmar Porschke
    Pages 241-258
  14. Back Matter
    Pages 275-278

About this book

Introduction

In Drug-DNA Interactions, expert researchers describe powerful molecular techniques designed to illuminate and explore the interaction of drugs and ligands with DNA, often perfected in their own laboratories, . These easily reproducible methods involve sequence recognition properties, as well as physical approaches to measuring both the strength of interaction and the mode of drug binding to DNA. Drug interactions are also examined from a cellular perspective and for their usefulness in the development of new therapeutic agents.

Drug-DNA Interactions will be highly useful to all investigators needing the kind of detailed experimental and technical information often omitted from scientific papers. Those wishing to expand their repertoire of experimental techniques or to improve their current techniques will also find these powerful methods particularly helpful in elucidating the action of existing therapeutic agents, as well as in designing new anticancer drugs with improved action and reduced toxicity.






Editors and affiliations

  • Keith R. Fox
    • 1
  1. 1.University of SouthamptonUK

Bibliographic information

  • DOI https://doi.org/10.1385/089603447X
  • Copyright Information Humana Press 1997
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-447-1
  • Online ISBN 978-1-59259-574-7
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • About this book