Animal Models of Neurological Disease, II

Metabolic Encephalopathies and the Epilepsies

  • Alan A. Boulton
  • Glen B. Baker
  • Roger F. Butterworth

Part of the Neuromethods book series (NM, volume 22)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Karen A. Seta, R. Christian Crumrine, Tim S. Whittingham, W. David Lust, David W. McCandless
    Pages 1-50
  3. Gary E. Gibson, Hsueh-Meei Huang
    Pages 51-93
  4. Maryse Héroux, Roger F. Butterworth
    Pages 95-131
  5. David W. McCandless, Ross B. FineSmith
    Pages 133-151
  6. Marc S. Abel, David W. McCandless
    Pages 153-168
  7. David W. McCandless, Marc S. Abel
    Pages 169-182
  8. Andres T. Blei, Reed Omarg, Roger F. Butterworth
    Pages 183-222
  9. M. G. Murphy, S. C. Digout, J. F. S. Crocker
    Pages 223-257
  10. Frederick C. Kauffman
    Pages 259-297
  11. Krishnamurti Dakshinamurti, S. K. Sharma, K. J. Lal
    Pages 299-327
  12. Ijaz A. Qureshi
    Pages 329-356
  13. Back Matter
    Pages 357-373

About this book


to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neuropsychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further - search using animals is necessary and why animal models of psychiatric disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. However, when the distress, discomfort, or pain to the animals outweighs the anticipated gains for human welfare, then the research is not ethical and should not be carried out. It is imperative that each individual researcher examine his/her own research from a critical moral standpoint - fore engaging in it, taking into consideration the animals’ welfare as well as the anticipated gains. Furthermore, once a decision to proceed with research is made, it is the researcher’s responsibility to ensure that the animals’ w- fare is of prime concern in terms of appropriate housing, feeding, and maximum reduction of any uncomfortable or distressing effects of the experimental conditions, and that these conditions undergo frequent formalized monitoring.

Editors and affiliations

  • Alan A. Boulton
    • 1
  • Glen B. Baker
    • 2
  • Roger F. Butterworth
    • 3
  1. 1.University of SaskatchewanSaskatoonCanada
  2. 2.University of AlbertaEdmontonCanada
  3. 3.University of MontrealMontrealCanada

Bibliographic information

  • DOI
  • Copyright Information Humana Press 1992
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-211-8
  • Online ISBN 978-1-59259-627-0
  • Series Print ISSN 0893-2336
  • Series Online ISSN 1940-6045
  • Buy this book on publisher's site