Intracellular Messengers

  • Alan A. Boulton
  • Glen B. Baker
  • Colin W. Taylor

Part of the Neuromethods book series (NM, volume 20)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Colin W. Taylor, Jennifer M. Bond, David L. Nunn, Katherine A. Oldershaw
    Pages 79-128
  3. Roger B. Moreton
    Pages 175-230
  4. Gillian M. Burgess
    Pages 231-272
  5. Barry V. L. Potter
    Pages 273-312
  6. Kenneth J. Murray
    Pages 313-368
  7. David B. Morton
    Pages 397-431
  8. Hugh R. Matthews, Trevor D. Lamb
    Pages 471-516
  9. Back Matter
    Pages 565-580

About this book

Introduction

Despite the success of earlier Neuromethads volumes, I was initially reluctant to edit a further volume because my own - search is concerned with nonneural tissues. I changed my mind for two simple reasons. First, though the sheer diversity of ext- cellular signal molecules is staggering, still more impressive is the remarkably small number of transmembrane signaling processes they recruit- their receptors either have integral ion channels or enzyme activities, or else they catalytically activate G proteins. Likewise, when we look to the final intracellular t- gets of these signaling pathways, they are stucturally diverse, but again there are common themes: the response may either be the gating of an ion channel, or else the phosphorylation of a target protein. Such conservation of signaling mechanisms is both impressive and convenient, and provides my justification for asking authors with interests in diverse tissues to contribute their methodological expertise to this volume. Second, I think it would be difficult to overestimate the extent to which our understanding of intracellular signaling has been transformed by new and improved methodology. Thus, simple methods for measuring inositol phosphates have revealed the profound and widespread importance of the ph- phoinositide pathways, the techniques of contemporary - lecular biology have provided unrivaled opportunities to relate structure and function, and the complex spatial and t- poral characteristics of intracellular signaling pathways were barely imaginable before the introduction of fluorescent indi- tors and single cell-imaging technology.

Editors and affiliations

  • Alan A. Boulton
    • 1
  • Glen B. Baker
    • 2
  • Colin W. Taylor
    • 3
  1. 1.University of SaskatchewanSaskatoonCanada
  2. 2.University of AlbertaEdmontonCanada
  3. 3.University of CambridgeCambridgeUK

Bibliographic information

  • DOI https://doi.org/10.1385/0896032078
  • Copyright Information Humana Press 1992
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-0-89603-207-1
  • Online ISBN 978-1-59259-625-6
  • Series Print ISSN 0893-2336
  • Series Online ISSN 1940-6045
  • About this book