Cardiovascular Proteomics

Methods and Protocols

  • Fernando Vivanco

Part of the Methods in Molecular Biology™ book series (MIMB, volume 357)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Analysis of the Heart Proteome

    1. Front Matter
      Pages 1-1
    2. Anthony O. Gramolini, Thomas Kislinger, Peter Liu, David H. MacLennan, Andrew Emili
      Pages 15-31
    3. Jun Sakai, Hironori Ishikawa, Hideshi Satoh, Setsuko Yamamoto, Shinichi Kojima, Masaharu Kanaoka
      Pages 33-43
    4. Alberto Lázaro, Julio Gállego-Delgado, Julio I. Osende, Jesús Egido, Fernando Vivanco
      Pages 45-58
    5. Brian A. Stanley, Jennifer E. Van Eyk
      Pages 67-70
  3. Heart Subproteomes

    1. Front Matter
      Pages 71-71
    2. Mariana Eça, Lukas Alfons Huber
      Pages 73-85
    3. Lesley A. Kane, Irina Neverova, Jennifer E. Van Eyk
      Pages 87-90
    4. Diane E. Bovenkamp, Brian A. Stanley, Jennifer E. Van Eyk
      Pages 91-102
  4. Proteomics of Human Atheroma Plaques

    1. Front Matter
      Pages 139-139
    2. Mari-Carmen Durán, Jose L. Martin-Ventura, Sebastián Mas, Maria G. Barderas, Verónica M. Dardé, Ole N. Jensen et al.
      Pages 141-150
    3. Mari-Carmen Durán, Elisabetta Boeri-Erba, Shabaz Mohammed, Jose L. Martin-Ventura, Jesús Egido, Fernando Vivanco et al.
      Pages 151-163
  5. The Proteome of Cells of the Cardiovascular System

    1. Front Matter
      Pages 179-179
    2. Jesús González-Cabrero, Mayte Pozo, Mari-Carmen Durán, Rosario de Nicolás, Jesús Egido, Fernando Vivanco
      Pages 181-198
    3. Richard R. Sprenger, Anton J. G. Horrevoets
      Pages 199-213
    4. Antonio Martínez-Ruiz, Santiago Lamas
      Pages 215-223
    5. Annabelle Dupont, Florence Pinet
      Pages 225-233
    6. Timothy D. O’Connell, Manoj C. Rodrigo, Paul C. Simpson
      Pages 271-296
    7. Peng-Yuan Yang, Yao-Cheng Rui, Peng-Yuan Yang, Yan-Ling Yu
      Pages 297-305
    8. Judith Coppinger, Desmond J. Fitzgerald, Patricia B. Maguire
      Pages 307-311
    9. Martina Foy, Donal F. Harney, Kieran Wynne, Patricia B. Maguire
      Pages 313-318
    10. Maria G. Barderas, Verónica M. Dardé, Mari-Carmen Durán, Jesús Egido, Fernando Vivanco
      Pages 319-328
  6. Cardiovascular Biomarkers in Plasma

    1. Front Matter
      Pages 329-329
    2. Olivier Meilhac, Sandrine Delbosc, Jean-Baptiste Michel
      Pages 331-341
    3. Jean-Charles Sanchez, Pierre Lescuyer, Denis Hochstrasser, Laure Allard
      Pages 343-350
  7. Bioinformatics: Emerging Technologies

    1. Front Matter
      Pages 373-373
    2. Purnima Guda, Shankar Subramaniam, Chittibabu Guda
      Pages 375-383
    3. Dawn R. Christianson, Michael G. Ozawa, Renata Pasqualini, Wadih Arap
      Pages 385-406
  8. Back Matter
    Pages 407-420

About this book


Over the past few years, the power and potential of proteomics has become widely recognized. The use of proteomics for the study of complex diseases is increasing and is particularly applicable to cardiovascular disease, the leading cause of death in developed countries. The ability to investigate the complete proteome provides a critical tool toward elucidating the complex and multif- torial basis of cardiovascular biology, especially disease processes. Proteomics involves the integration of a number of technologies with the aim of analyzing all the proteins expressed by a biological system in response to various stimuli under different pathophysiological conditions. The proteomic approach offers the ability to evaluate simultaneously the changes in protein expression and cell signaling pathways in response to such conditions as atherosclerosis, c- diac hypertrophy, stroke, or heart failure. Cardiovascular Proteomics: Methods and Protocols covers many of the above aspects of the proteomic approach in the cardiovascular field. This v- ume takes the reader through the complete process of proteomic analysis, from the obtention of specific heart proteins (troponin I) to the new techniques of identifying risk biomarkers of atherome plaque rupture, analyzing the secretome of explanted endarterectomies cultured in vitro, or the application of phage display techniques to decipher the molecular diversity of blood vessels.


Proteomics Translation Vivo bioinformatics cardiovascular hypertension platelets protein sequence proteins

Editors and affiliations

  • Fernando Vivanco
    • 1
    • 2
  1. 1.Department of Immunology, Fundación Jiménez DíazUniversidad ComplutenseMadridSpain
  2. 2.Department of Biochemistry and Molecular Biology IUniversidad ComplutenseMadridSpain

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2007
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-535-4
  • Online ISBN 978-1-59745-214-4
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site