Protein Design

Methods and Applications

  • Raphael Guerois
  • Manuela López de la Paz

Part of the Methods in Molecular Biology book series (MIMB, volume 340)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Design of Structural Elementary Motifs

    1. Front Matter
      Pages 1-1
    2. Neil Errington, Teuku Iqbalsyah, Andrew J. Doig
      Pages 3-26
    3. David Pantoja-Uceda, Clara M. Santiveri, M. Angeles Jiménez
      Pages 27-51
    4. Luke H. Bradley, Peter P. Thumfort, Michael H. Hecht
      Pages 53-69
    5. Radhakrishnan Mahalakshmi, Padmanabhan Balaram
      Pages 71-94
    6. Marc J. Koyack, Richard P. Cheng
      Pages 95-109
  3. Design Of Entire Proteins And Protein Complexes

    1. Front Matter
      Pages 111-111
    2. François Stricher, Loïc Martin, Claudio Vita
      Pages 113-149
    3. Tommi Kajander, Aitziber L. Cortajarena, Lynne Regan
      Pages 151-170
    4. Hocine Madaoui, Emmanuelle Becker, Raphael Guerois
      Pages 183-206
    5. Gregorio Fernandez-Ballester, Luis Serrano
      Pages 207-234
    6. Gideon Schreiber, Yossi Shaul, Kay E. Gottschalk
      Pages 235-249
  4. Design of Amyloidogenic Polypeptides and Amyloid Inhibitors

    1. Front Matter
      Pages 251-251
    2. Alexandra Esteras-Chopo, María Teresa Pastor, Manuela López de la Paz
      Pages 253-276
    3. Lisbell D. Estrada, June Yowtak, Claudio Soto
      Pages 277-293
  5. Back Matter
    Pages 295-299

About this book


Recent major advances in our understanding of modulating protein functions has led to the development of new methods and algorithms to predict and decipher how amino acid sequences shape three-dimensional structures. Protein Design: Methods and Applications presents the most up-to-date protein design and engineering strategies so that readers can undertake their own projects with a maximum chance of success.
The authors present integrated computational approaches that require various degrees of computational complexity, and the major accomplishments that have been achieved in the design and structural characterization of helical peptides and proteins. Other topics of discussion include: design of structural elementary motifs, entire proteins, and interfaces of protein complexes, and of amyloidogenic polypeptides and amyloid inhibitors.
Authoritative and cutting-edge, Protein Design: Methods and Applications will be of major interest to protein scientists, biochemists, and all experimentalists selecting the strategy most adaptable for their design problem.


Amino acid Secondary structure protein complexes protein structure proteins

Editors and affiliations

  • Raphael Guerois
    • 1
  • Manuela López de la Paz
    • 2
  1. 1.Département de Biologie Joliot–Curie CEA SaclayGif-sur-YvetteFrance
  2. 2.Merz Pharmaceuticals GmbHFrankfurt am MainGermany

Bibliographic information

  • DOI
  • Copyright Information Humana Press 2006
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-58829-585-9
  • Online ISBN 978-1-59745-116-1
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site